1. Articles from Ryan Sentosa

    1-3 of 3
    1. Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      We have developed a multimodal laser scanning microscope (LSM) platform combining optical coherence tomography (OCT), spectral focusing coherent anti-Stokes Raman scattering (SF-CARS), second harmonic generation (SHG) and two-photon excited fluorescence (TPF). Morphological, molecular and biochemical information from tissues can be collected in a non-invasive and label-free manner by merging ultra-fast Ti:sapphire lasers with well-developed optical imaging techniques. The combination of the proposed imaging modalities enables increased sensitivity and specificity for detection of early tissue alteration related to pathological condition and may offer novel insights in the diagnosis of diseases. OCT is fused with nonlinear optical microscopy techniques to perform ...

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    2. Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Multimodal imaging platforms offer a vast array of tissue information in a single image acquisition by combining complementary imaging techniques. By merging different systems, better tissue characterization can be achieved than is possible by the constituent imaging modalities alone. The combination of optical coherence tomography (OCT) with non-linear optical imaging (NLOI) techniques such as two-photon excited fluorescence (TPEF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) provides access to detailed information of tissue structure and molecular composition in a fast, label-free and non-invasive manner. We introduce a multimodal label-free approach for morpho-molecular imaging and spectroscopy and validate the ...

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    3. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder wall for suspicious lesions with the ability to discriminate malignant tissue from healthy urothelium. Upon identification of degenerated tissue via OCT, RS was implemented to determine the molecular characteristics via ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Medical University of Vienna
    2. (3 articles) Angelika Unterhuber
    3. (3 articles) Wolfgang Drexler
    4. (3 articles) Ryan Sentosa
    5. (3 articles) Mikael Timo Erkkilä
    6. (3 articles) National Institutes of Health
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    11. (1 articles) University of Southern California
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    16. (1 articles) Lars Kirsten
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