1. Articles from Liqun Jiao

    1-7 of 7
    1. Macrocalcification of intracranial vertebral artery may be related to in-stent restenosis: lessons learned from optical coherence tomography

      Macrocalcification of intracranial vertebral artery may be related to in-stent restenosis: lessons learned from optical coherence tomography

      Background: Calcification has been proven to be a marker of atherosclerosis and is related to an increased risk of ischemic stroke. Additionally, calcification was reported to be prevalent in patients with stenotic lesions of the intracranial vertebral artery. Thus, reliable imaging facilities for evaluating plaque calcification have remarkable significance in guiding stenting and predicting patient outcomes. Optical coherence tomography (OCT) has a unique advantage in its ability to detect calcium and to achieve three-dimensional volumetric calcium characterization. Methods: From March 2017 to September 2018, seven cases of calcified lesions with intracranial vertebral artery stenosis were investigated using OCT, before and ...

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    2. Frequency-Domain Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis: Feasibility, Safety, and Preliminary Experience

      Frequency-Domain Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis: Feasibility, Safety, and Preliminary Experience

      Background: Despite advances in non-invasive imaging, the characterization of atherosclerotic plaque remains superior with frequency-domain optical coherence tomography (FD-OCT) in the clinical coronary and experimental cerebrovascular literature. An assessment of the feasibility and safety of FD-OCT for intracranial atherosclerotic stenosis (ICAS) is desirable. Methods: We analyzed a cohort of all consecutive FD-OCT evaluations for ICAS performed at our institution from April 2017 to August 2018 (16 months) in patients who suffered from transient ischemic attack (TIA) or non-disabling stroke despite optimal medical management within 90 days of admission attributable to angiographically verified 70-99% stenosis of an intracranial artery. Results: Thirty-three ...

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    3. Optical Coherence Tomography of Plaque Erosion and Thrombus in Severe Vertebral Artery Stenosis

      Optical Coherence Tomography of Plaque Erosion and Thrombus in Severe Vertebral Artery Stenosis

      A 69-year-old male presented with medically refractory vertebrobasilar insufficiency and paroxysmal subjective dizziness for six months. Severe stenosis of a dominant left V2 vertebral artery segment was identified on digital subtraction angiography (DSA) with an irregular intraluminal filling defect immediately above the stenosis. Optical coherence tomography (OCT) demonstrated a normal lumen at the distal end, with red thrombus detected distal to the stenosis. Atherosclerotic plaque containing fibro-lipid was also identified and treated with a drug-eluting stent. Distal red thrombi were not covered by stenting, indicating embolization risk in the future. Clear posterior fossa symptoms occurred after intervention, and treatment with ...

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    4. Neovascularization in Human Intracranial Atherosclerotic In-Stent Restenosis

      Neovascularization in Human Intracranial Atherosclerotic In-Stent Restenosis

      Optical coherence tomography (OCT) has seen widespread use in cardiovascular and interventional endovascular imaging. While scattered reports of intracranial usage have been reported for the assessment of atherosclerotic stenosis, nutrifying neovasculature supplying plaque and neointima have not been demonstrated until now. We report the first in-vivo illustration of this phenomenon, which is a high-resolution depiction of a critical pathway for in-stent restenosis.

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    5. Correlation between intracranial vertebral artery stenosis diameter measured by digital subtraction angiography and cross-sectional area measured by optical coherence tomography

      Correlation between intracranial vertebral artery stenosis diameter measured by digital subtraction angiography and cross-sectional area measured by optical coherence tomography

      Background: Intracranial vertebral artery (V4 segment) stenosis quantification traditionally uses the narrowest stenosis diameter. However, the stenotic V4 lumen is commonly irregularly shaped. Optical coherence tomography (OCT) allows a more precise calculation of V4 geometry. We compared the narrowest diameter stenosis (DS), measured by digital subtraction angiography (DSA), with the area stenosis (AS), measured by OCT. We hypothesized that DS is the gold standard for measuring the degree of stenosis. Methods: Five neuroradiologists evaluated 49 stenosed V4 segments in a blinded protocol. V4 stenosis was measured in millimeters on DSA at its narrowest diameter. OCT was used to estimate the ...

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    6. Visualization of the Human Intracranial Vasa Vasorum In Vivo Using Optical Coherence Tomography

      Visualization of the Human Intracranial Vasa Vasorum In Vivo Using Optical Coherence Tomography

      The vasa vasorum are a specialized microvasculature that mainly arise from the adventitia and traverse the intimomedial layer of large arteries and veins. These are felt to serve as crucial routes of the delivery for trophic and nutritive factors, as well as regulatory signals. 1 Importantly, they also play a role in pathology via proliferation in atherosclerotic and hypertrophic intimomedia, as well as plaque hemorrhage and dissection via rupture. 2 In the setting of symptomatic vertebral artery stenosis, we report what is, to our knowledge, the first known in vivo visualization of the human native intracranial arterial vasa vasorum and ...

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    7. Optical coherence tomography of spontaneous basilar artery dissection in a patient with acute ischemic stroke

      Optical coherence tomography of spontaneous basilar artery dissection in a patient with acute ischemic stroke

      The diagnosis of intracranial arterial dissection (IAD) may be challenging and multimodal imaging techniques are often needed to confirm the diagnosis. Previous studies have based their criteria for diagnosis of IAD on conventional angiography, computed tomography or magnetic resonance imaging. We report a case with acute ischemic stroke due to spontaneous basilar artery dissection in which intravascular optical coherence tomography (OCT) was used to show features of IAD. A 59-year-old woman presented with symptoms of acute ischemic stroke. Thrombosis related to basilar artery (BA) stenosis was assumed on conventional angiography; however, no clot was retrieved after mechanical thrombectomy (MT) and ...

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    1-7 of 7
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    Optical coherence tomography of spontaneous basilar artery dissection in a patient with acute ischemic stroke Visualization of the Human Intracranial Vasa Vasorum In Vivo Using Optical Coherence Tomography Correlation between intracranial vertebral artery stenosis diameter measured by digital subtraction angiography and cross-sectional area measured by optical coherence tomography Neovascularization in Human Intracranial Atherosclerotic In-Stent Restenosis Optical Coherence Tomography of Plaque Erosion and Thrombus in Severe Vertebral Artery Stenosis Frequency-Domain Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis: Feasibility, Safety, and Preliminary Experience Macrocalcification of intracranial vertebral artery may be related to in-stent restenosis: lessons learned from optical coherence tomography Vascular and Structural Alterations of the Choroid Evaluated by Optical Coherence Tomography Angiography and Enhanced-Depth Imaging Optical Coherence Tomography in Eyes with Reticular Pseudodrusen and Soft Drusen Total venous nature of retinal deep capillary plexus inferred by continuity of prominent middle limiting membrane sign in optical coherence tomography Evaluating Onychomycosis Outcomes 2 Months into an 11-month-long Efinaconazole Regimen: The Role of Optical Coherence Tomography Accuracy of Common Motion Estimators in Wave-Based  Optical Coherence Elastography Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopy