1. Articles from J. T. Annema

    1-3 of 3
    1. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway smooth muscle detection in bronchial thermoplasty treated asthma patients

      Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway smooth muscle detection in bronchial thermoplasty treated asthma patients

      To the editor, 79 Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), 80 including thickening of airway smooth muscle (ASM) as a key element of this alteration (1). 81 Severe asthma patients may benefit from bronchial thermoplasty (BT), an endoscopic 82 treatment that targets structural AR and induces ASM reduction (2). Assessment of AR is 83 critical to evaluate the impact of BT and might provide a tool for BT patient selection. 84 Polarization sensitive optical coherence tomography (PS-OCT) has been proposed as a 85 minimally invasive diagnostic method to assess ASM mass as alternative to focal ...

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    2. Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix

      Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix

      Introduction: Airway diseases are characterized by structural airway remodeling, including extracellular matrix (ECM) changes. Although a key feature, no diagnostic test currently assesses airway remodeling other than invasive airway biopsies. Real-time optical coherence tomography (OCT) generates infrared-based cross-sectional images of airway segments. Previously we reported that OCT identifies and quantifies airway wall layers. We hypothesized that OCT is able to detect collagen deposition areas within the airway wall ECM. Methods: In 5 lobectomy specimens 13 airways were dissected, marked with needles for matching histology and imaged by OCT. Sections were stained for total collagen (TC; pico sirius red) and collagen ...

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    3. Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma

      Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma

      Background: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. Objective: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects of BT by OCT and compare these to the untreated right middle lobe (RML). Methods: Severe asthma patients were treated with BT (TASMA trial). During the third BT procedure, OCT ...

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    1-3 of 3
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