1. Articles from Nyein C. Lwin

    1-3 of 3
    1. Optical Coherence Tomography Angiography Imaging to monitor Anti-VEGF treatment of Corneal Vascularization in a Rabbit Mode

      Optical Coherence Tomography Angiography Imaging to monitor Anti-VEGF treatment of Corneal Vascularization in a Rabbit Mode

      Optical coherence tomography angiography (OCTA) is a well-established non-invasive retinal vascular imaging technique. It has been recently adapted to image the anterior segment and has shown good potential to image corneal vascularisation. The purpose of the study is to evaluate the usefulness of OCTA to monitor regression of corneal vessels following anti-VEGF (vascular endothelial growth factor) treatment using a previously established corneal vascularisation rabbit model. The regression of vessels following the treatment with aflibercept and ranibizumab anti-VEGFs using both topical instillation and sub-conjunctival injection was quantified using OCTA and compared with ICGA (indocyanine green angiography). Overall vessel density measurements using ...

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    2. Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model

      Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model

      Background Optical coherence tomography angiography (OCTA) is a novel non-invasive angiography technology that has recently been extensively studied for its utility in anterior segment imaging. In this study, we compared a split-spectrum amplitude decorrelation angiography (SSADA) OCTA and an optical micro-angiography (OMAG SD) OCTA system to current angiographic technique, indocyanine green angiography (ICGA), to assess corneal vascularisation in an animal model. Methods We imaged 16 rabbits, (one eye per animal) with corneal vascularisation using SSADA OCTA (AngioVue; Optovue Inc., USA), OMAG OCTA (Angioscan; RS-3000 Nidek Co. Ltd., Japan) and ICGA in the same region of interest of the cornea at ...

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    3. Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model

      Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model

      Corneal neovascularization (CoNV) could be treated by novel anti-angiogenic therapies, though reliable and objective imaging tools to evaluate corneal vasculature and treatment efficacy is still lacking. Optical coherence tomography angiography (OCTA) –currently designed as a retinal vascular imaging system— has been recently adapted for anterior-segment and showed good potential for successful imaging of CoNV. However, further development requires an animal model where parameters can be studied more carefully with histological comparison. Our study evaluated the OCTA in suture-induced CoNV in a rabbit model compared to indocyanine green angiography (ICGA) and slit-lamp photography (SLP). Overall vessel density measurements from OCTA showed ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Jodhbir S. Mehta
    2. (2 articles) Singapore Eye Research Institute
    3. (1 articles) Medical University of Vienna
    4. (1 articles) Nanyang Technological University
    5. (1 articles) Optovue
    6. (1 articles) Nidek
    7. (1 articles) Yonsei University
    8. (1 articles) Shanghai Jiao Tong University
    9. (1 articles) Tokyo Medical & Dental University
    10. (1 articles) University of Washington
    11. (1 articles) Junji Tagami
    12. (1 articles) Yasushi Shimada
    13. (1 articles) Alireza Sadr
    14. (1 articles) Dong Hoon Choi
    15. (1 articles) Avinger
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