1. Articles from Kazuhiro Fujiyoshi

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    1. Endothelial glycocalyx and severity and vulnerability of coronary plaque in patients with coronary artery disease

      Endothelial glycocalyx and severity and vulnerability of coronary plaque in patients with coronary artery disease

      Background and aims Endothelial glycocalyx covers the endothelium and maintains vascular integrity. However, its association with the severity and vulnerability of coronary artery disease (CAD) remains to be elucidated. Methods A total of 259 consecutive patients with stable CAD requiring percutaneous coronary intervention (PCI) were prospectively enrolled. Patients were classified into 2 groups according to the median value of serum syndecan-1, which is a core component of the endothelial glycocalyx (lower syndecan-1 group [syndecan-1 <99.0 ng/mL], n = 130; higher syndecan-1 group [syndecan-1 ≥99.0 ng/mL], n = 129). Severity of CAD and focal plaque vulnerability in culprit lesion ...

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    2. Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study

      Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study

      Background High lipoprotein (a) [Lp(a)] levels are an independent factor for worse prognosis in patients with coronary artery disease (CAD). However, the association between serum Lp(a) level and coronary plaque vulnerability remains to be determined. Methods A total of 255 consecutive patients with CAD who underwent optical coherence tomography imaging of culprit lesions were included. Patients were divided into 2 groups according to their Lp(a) levels (the higher Lp(a) group [≥25 mg/dL], n = 87; or the lower Lp(a) group [<25 mg/dL], n = 168). Results The prevalence of thin-cap fibroatheroma (TCFA) was significantly higher ...

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    3. Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study

      Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study

      Background and aims Intraplaque cholesterol crystal (CC) is recognized as a component of vulnerable plaques. However, the clinical characteristics of patients with CC and the impact of CC on clinical events remain unknown. Methods A total of 340 consecutive patients who underwent optical coherence tomography (OCT) imaging of culprit lesions were included in the study. CC was defined as a thin linear structure with high reflectivity and low signal attenuation on OCT images. The incidence of major adverse cardiovascular events (MACE) at 1-year was compared between patients with CC (CC group) and those without CC (non-CC group). MACE included cardiac ...

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    4. Achilles tendon thickening is associated with disease severity and plaque vulnerability in patients with coronary artery disease

      Achilles tendon thickening is associated with disease severity and plaque vulnerability in patients with coronary artery disease

      Background Tendon xanthomas are accumulations of collagen and macrophages which contain cholesterol esters and a marker of high risk for coronary artery disease (CAD). Objective To clarify whether the presence of Achilles tendon thickening (ATT) was associated with disease severity and plaque vulnerability in patients with CAD. Methods A total of 241 consecutive patients who underwent percutaneous coronary intervention and ATT assessment were analyzed. ATT was defined as Achilles tendon thickness of 9 mm or more on radiograph. The severity of CAD and plaque vulnerability were assessed by the findings on angiogram and optical coherence tomography, respectively. Results ATT was ...

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    5. Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation

      Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation

      Background The aim of this study was to investigate whether the underlying plaque type affects the neointimal coverage after drug-eluting stent implantation. Methods A total of 1793 struts in 22 zotarolimus-eluting stents were assessed using optical coherence tomography imaging within 3 months of implantation. Neointimal coverage was evaluated within 5 mm from each stent edge on cross-sectional optical coherence tomography images at every 1-mm interval. The percentage of struts covered by neointima was compared among the normal segment group, the fibrous plaque group, and the lipid plaque group on the basis of the underlying plaque type. Results The percentage of ...

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    1-5 of 5
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    Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation Achilles tendon thickening is associated with disease severity and plaque vulnerability in patients with coronary artery disease Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study Endothelial glycocalyx and severity and vulnerability of coronary plaque in patients with coronary artery disease Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology Measurement of optic axis orientation with single-mode fiber-based polarization-sensitive optical coherence tomography Investigating Local Polarisation Contrast With Fibre-Based Polarisation-Sensitive Optical Coherence Tomography and Microscopy (Thesis) Fundus fluorescein angiography and optical coherence tomography findings in ocular and non-ocular Behҫet’s disease Optical Coherence Tomography as a Diagnostic Adjunct for Ocular Surface Lesions The impact of therapeutic mediastinal radiation on stent healing in cancer patients: An optical coherence tomography study. Optical Coherence Tomography and Its Non-medical Applications (Textbook)