1. Articles from Deepayan Kar

    1-4 of 4
    1. Mitochondrial distribution in the outer plexiform layer of human retina - Does it correlate with reflectivity in OCT?

      Mitochondrial distribution in the outer plexiform layer of human retina - Does it correlate with reflectivity in OCT?

      Mitochondria are organelles essential for cellular metabolism that also contribute reflectivity to optical coherence tomography (OCT) via Mie scattering. To find reflectivity sources, we assessed mitochondrial distribution of outer plexiform layer (OPL) using comprehensive volume electron microscopy. Parafoveal retina of a 21-year-old male donor was subject to serial block-face scanning electron microscopy in 5×5×50 nm³ voxels. A convolutional neural network (U-Net) was used to train and generate a deep learning model from manually annotated mitochondria ground truth (Dragonfly 2020.1, Object Research Systems). Using this model, mitochondrial volume and occupancy were calculated as a function of retinal depth ...

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    2. Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

      Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

      Purpose: By optical coherence tomography (OCT) imaging, hyperreflective foci (HRF) indicate progression risk for advanced age-related macular degeneration (AMD) and are in part attributable to ectopic retinal pigment epithelium (RPE). We hypothesized that ectopic RPE are molecularly distinct from in-layer cells and that their cross-retinal course follows Müller glia. Methods: In clinical OCT (61 eyes, 44 patients with AMD, 79.4 ± 7.7 years; 29 female; follow-up = 4.7 ± 0.9 years), one HRF type, RPE plume (n = 129 in 4 morphologies), was reviewed. Twenty eyes of 20 donors characterized by ex vivo OCT were analyzed by histology (normal ...

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    3. Differences in optical coherence tomography assessment of radial peripapillary capillaries with axial length and optic nerve head morphology (Thesis)

      Differences in optical coherence tomography assessment of radial peripapillary capillaries with axial length and optic nerve head morphology (Thesis)

      INTRODUCTION: Optic nerve head morphological parameters and axial length have been shown to be associated with altered retinal perfusion and microvascular characteristics. The radial peripapillary capillaries (RPC) are a fine network of vessels embedded within the retinal nerve fiber layer which can be visualized using optical coherence tomography (OCT) angiography. RPC is susceptible to ocular hypertension, ischemia, trauma, or biomechanical stress. Since axially myopic eyes have greater propensity for developing glaucoma, assessing the relationship between morphological parameters and RPC characteristics may contribute to evidence important to understanding the pathophysiology of glaucoma and other optic neuropathies. PURPOSE: To investigate the association ...

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    1-4 of 4
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    1. (3 articles) University of Alabama
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