Articles from Clement C. Tham

1. Relationship between macular intercapillary area measured by optical coherence tomography angiography and central visual field sensitivity in normal tension glaucoma

   Explore BJO Online Feb 7 2022 Ophthalmology

   

   Purpose To investigate the relationship of macular intercapillary area (ICA) with macular ganglion cell-inner plexiform layer (GCIPL) thickness and central visual field sensitivity (CVFS) in normal tension glaucoma (NTG). Methods Seventy-eight early NTG eyes, 33 moderate-to-severe NTG eyes and 75 normal control eyes were cross-sectional evaluated. All participants underwent swept-source optical coherence tomography angiography (OCT-A; DRI-OCT, Topcon, Tokyo, Japan). A customised MATLAB program was used to quantify macular OCT-A metrics at central 3×3 mm macular region including vascular density (VD), foveal avascular zone (FAZ) area, 10 largest ICA including FAZ area (ICA10_IncFAZ) and excluding FAZ area (ICA10_ExcFAZ). Generalised estimating ...

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   Mentions: Topcon Medical Systems The Chinese University of Hong Kong

2. A Multitask Deep-Learning System to Classify Diabetic Macular Edema for Different Optical Coherence Tomography Devices: A Multicenter Analysis

   Explore Home | Diabetes Care Jul 27 2021 Ophthalmology

   

   OBJECTIVE Diabetic macular edema (DME) is the primary cause of vision loss among individuals with diabetes mellitus (DM). We developed, validated, and tested a deep learning (DL) system for classifying DME using images from three common commercially available optical coherence tomography (OCT) devices. RESEARCH DESIGN AND METHODS We trained and validated two versions of a multitask convolution neural network (CNN) to classify DME (center-involved DME [CI-DME], non-CI-DME, or absence of DME) using three-dimensional (3D) volume scans and 2D B-scans, respectively. For both 3D and 2D CNNs, we used the residual network (ResNet) as the backbone. For the 3D CNN, we ...

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   Mentions: Carl Zeiss Meditec

3. The association between attention-deficit/hyperactivity disorder and retinal nerve fiber/ganglion cell layer thickness measured by optical coherence tomography: a systematic review and meta-analysis

   Explore Home - Springer May 21 2021 Ophthalmology

   

   Purpose: Retinal nerve fiber/ganglion cell layer (RNFL/GCL) thickness measured using optical coherence tomography has been proposed as an ocular biomarker for children with attention-deficit/hyperactivity disorder (ADHD), but findings varied in different studies. This study aims to determine the association between RNFL/GCL thickness and ADHD in children by systematic review and meta-analysis. Methods: We performed a literature search in Embase, PubMed, Medline, Web of Science, and PsycINFO for relevant articles published up to February 29, 2020. All studies with original data comparing RNFL/GCL thickness in ADHD and healthy children were included. The Newcastle Ottawa Scale was ...

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   Mentions: The Chinese University of Hong Kong University of Hong Kong

4. Characterization of macular choroid in normal-tension glaucoma: a swept-source optical coherence tomography study

   Explore Wiley Online Library Mar 8 2021 Ophthalmology

   

   Purpose: To investigate the features of the small-to-medium (choriocapillaris and Sattler's layer) and large (Haller's layer) sized vessel layers of the macular choroid in normal-tension glaucoma (NTG) patients using swept-source optical coherence tomography (SS-OCT). Methods: We conducted an observational cross-sectional study in 234 NTG eyes from 134 patients, and 203 normal eyes from 109 non-glaucomatous control subjects. We used Image J to segment the choroidal layer and then a Python script to measure the average macular choroidal thickness (MCT) and choroidal vascular index (CVI) of two vessel layers at five different locations. Quantitative optical coherence tomography angiography (OCTA ...

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   Mentions: The Chinese University of Hong Kong

5. Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

   Explore IOVS Journal Jan 29 2021 Ophthalmology

   

   Purpose : To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics in primary open-angle glaucoma (POAG) eyes with and without high myopia. Methods : In total, 63 and 61 POAG eyes with and without high myopia, respectively, underwent swept-source OCTA imaging in at least four follow-up visits at an ophthalmic center, with a scanning protocol of 3- × 3-mm centered at the fovea. The foveal avascular zone (FAZ) area, FAZ circularity, and vessel density (VD) in both the superficial (SCP) and deep capillary plexuses (DCP) were measured. The rate of change in macular OCTA metrics over ...

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   Mentions: Sun Yat-Sen University

6. Deep learning in glaucoma with optical coherence tomography: a review

   Explore Nature Publishing Group Oct 7 2020 Ophthalmology

   

   Deep learning (DL), a subset of artificial intelligence (AI) based on deep neural networks, has made significant breakthroughs in medical imaging, particularly for image classification and pattern recognition. In ophthalmology, applying DL for glaucoma assessment with optical coherence tomography (OCT), including OCT traditional reports, two-dimensional (2D) B-scans, and three-dimensional (3D) volumetric scans, has increasingly raised research interests. Studies have demonstrated that using DL for interpreting OCT is efficient, accurate, and with good performance for discriminating glaucomatous eyes from normal eyes, suggesting that incorporation of DL technology in OCT for glaucoma assessment could potentially address some gaps in the current practice ...

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   Mentions: The Chinese University of Hong Kong

7. Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes

   Explore The JAMA Network Jun 26 2020 Ophthalmology

   

   Importance Microvascular abnormalities in amblyopia are becoming evident with high-resolution imaging, such as optical coherence tomography angiography (OCT-A); however, to our knowledge, the clinical significance and use of these findings are unknown. Objective To assess changes in quantitative OCT-A metrics in amblyopic eyes and explore their association with visual acuity in children. Design, Setting, and Participants This population-based nested case-control study included children aged 6 to 8 years who were consecutively recruited between January 2016 and July 2017 from the population-based Hong Kong Children Eye Study (HKCES) at the Chinese University of Hong Kong Eye Centre. All participants underwent OCT-A ...

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   Mentions: The Chinese University of Hong Kong Zhejiang University University of Hong Kong

8. Assessment of retinal neurodegeneration with spectral-domain optical coherence tomography: a systematic review and meta-analysis

   Explore Nature Publishing Group Jun 24 2020 Ophthalmology

   

   Objectives To comprehensively assess diabetic retinopathy neurodegeneration (DRN) as quantified by retinal neuronal and axonal layers measured with spectral-domain optical coherence tomography (SD-OCT) in subjects with diabetes mellitus (DM). Methods Articles on the topic of examining macular ganglion cell-inner plexiform layer (m-GCIPL), macular retinal nerve fibre layer (m-RNFL), macular ganglion cell complex (m-GCC), and peripapillary RNFL (p-RNFL) measured with SD-OCT in DM subjects without DR (NDR) or with non-proliferative DR (NPDR) were searched in PubMed and Embase up to November 31, 2019. Standardized mean difference (SMD) as effect size were pooled using random-effects model. Results Thirty-six studies searched from online ...

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9. Towards multi-center glaucoma OCT image screening with semi-supervised joint structure and function multi-task learning

   Explore ScienceDirect May 23 2020 Ophthalmology

   

   Glaucoma is the leading cause of irreversible blindness in the world. Structure and function assessments play an important role in diagnosing glaucoma. Nowadays, Optical Coherence Tomography (OCT) imaging gains increasing popularity in measuring the structural change of eyes. However, few automated methods have been developed based on OCT images to screen glaucoma. In this paper, we are the first to unify the structure analysis and function regression to distinguish glaucoma patients from normal controls effectively. Specifically, our method works in two steps: a semi-supervised learning strategy with smoothness assumption is first applied for the surrogate assignment of missing function regression ...

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   Mentions: Stanford University The Chinese University of Hong Kong

10. Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

    Explore Eye and Vision Feb 7 2020 Ophthalmology

    

    Background To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus (DCP) metrics in patients with diabetes mellitus (DM). Methods 563 eligible eyes (221 with no diabetic retinopathy [DR], 135 with mild DR, 130 with moderate DR, and 77 with severe DR) from 334 subjects underwent optical coherence tomography-angiography (OCT-A) with a swept-source OCT (Triton DRI-OCT, Topcon, Inc., Tokyo, Japan). Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality, including projection artifacts, motion artifacts, blurriness, signal loss, B-scan segmentation error, or low-quality score. A customized MATLAB program was then used ...

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    Mentions: Topcon Medical Systems The Chinese University of Hong Kong

11. Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis

    Explore ScienceDirect Aug 13 2019 Ophthalmology

    

    Background Spectral-domain optical coherence tomography (SDOCT) can be used to detect glaucomatous optic neuropathy, but human expertise in interpretation of SDOCT is limited. We aimed to develop and validate a three-dimensional (3D) deep-learning system using SDOCT volumes to detect glaucomatous optic neuropathy. Methods We retrospectively collected a dataset including 4877 SDOCT volumes of optic disc cube for training (60%), testing (20%), and primary validation (20%) from electronic medical and research records at the Chinese University of Hong Kong Eye Centre (Hong Kong, China) and the Hong Kong Eye Hospital (Hong Kong, China). Residual network was used to build the 3D ...

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    Mentions: Stanford University The Chinese University of Hong Kong University of Hong Kong

12. Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening

    Explore arxiv.org Aug 3 2019 Ophthalmology

    

    Optical Coherence Tomography (OCT) imaging plays an important role in glaucoma diagnosis in clinical practice. Early detection and timely treatment can prevent glaucoma patients from permanent vision loss. However, only a dearth of automated methods has been developed based on OCT images for glaucoma study. In this paper, we present a novel framework to effectively classify glaucoma OCT images from normal ones. A semi-supervised learning strategy with smoothness assumption is applied for surrogate assignment of missing function regression labels. Besides, the proposed multi-task learning network is capable of exploring the structure and function relationship from the OCT image and visual ...

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    Mentions: Chinese Academy of Sciences The Chinese University of Hong Kong

13. Optical Coherence Tomography Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study

    Explore Ophthalmology Jul 1 2019 Ophthalmology

    

    Purpose To prospectively determine the relationship of optical coherence tomography angiography (OCTA) metrics to diabetic retinopathy (DR) progression and development of diabetic macular edema (DME). Design: Prospective, observational study. Participants Two hundred and five eyes from 129 patients with diabetes mellitus followed up for at least 2 years. Methods All subjects underwent OCTA with a swept-source OCT (DRI-OCT Triton, Topcon, Inc, Tokyo, Japan). Individual OCTA images of superficial capillary plexus (SCP) and deep capillary plexus (DCP) were generated by IMAGEnet6. After quality check, automated measurements of foveal avascular zone (FAZ) area, FAZ circularity, vessel density (VD) and fractal dimension (FD ...

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    Mentions: Topcon Medical Systems

14. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

    Explore ScienceDirect Aug 16 2018 Neurology , Ophthalmology

    

    Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer’s Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD. Methods We conducted a literature search in PubMed and EMBASE to identify studies published before 31 December 2017 ...

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    Mentions: Singapore Eye Research Institute National University of Singapore The Chinese University of Hong Kong

15. Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study

    Explore BJO Online Jul 4 2018 Ophthalmology

    

    Aims To evaluate the distributions of quantitative optical coherence tomography angiography (OCT-A) metrics and its associated factors in children. Methods 1059 children aged 6–8 years were recruited from the Hong Kong Children Eye Study. All the participants underwent OCT-A with a swept-source OCT. Retinal microvasculature on superficial capillary plexus was assessed and quantified by a customised automated image analysis programme. Univariable and multiple linear regression analyses were performed to determine systemic (body mass index (BMI), waist circumference, head circumference and blood pressure), demographic and ocular (axial length (AL), macular thickness and volume, retinal nerve fibre layer (RNFL) thickness and ...

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    Mentions: The Chinese University of Hong Kong

16. Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

    Explore BJO Online Jun 9 2018 Ophthalmology

    

    Aim To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients with diabetes, and to compare the strength of associations between BCVA with ICA and other OCT-A metrics. Methods A cross-sectional study involved 447 eyes from 299 patients with diabetes. All participants underwent OCT-A with a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme was used to quantify ICA (the mean of the 10 largest areas including foveal avascular zone (FAZ) area (ICA10_FAZ) and excluding FAZ area (ICA10_excFAZ)) and other OCT-A metrics (FAZ area ...

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    Mentions: The Chinese University of Hong Kong

Topics in the News

1. (12 articles) The Chinese University of Hong Kong
2. (3 articles) University of Hong Kong
3. (3 articles) Topcon Medical Systems
4. (2 articles) Stanford University
5. (1 articles) Sun Yat-Sen University
6. (1 articles) National University of Singapore
7. (1 articles) Singapore Eye Research Institute
8. (1 articles) Chinese Academy of Sciences
9. (1 articles) Zhejiang University
10. (1 articles) Erasmus University
11. (1 articles) Columbia University
12. (1 articles) University of Rochester
13. (1 articles) Stanford University
14. (1 articles) Johns Hopkins University
15. (1 articles) National University of Singapore

Popular Articles

• Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis  
• Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis  
• Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening  
• Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study  
• Optical Coherence Tomography Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study  
• Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study  
• A Multitask Deep-Learning System to Classify Diabetic Macular Edema for Different Optical Coherence Tomography Devices: A Multicenter Analysis  
• Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes  
• Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes  
• Towards multi-center glaucoma OCT image screening with semi-supervised joint structure and function multi-task learning  

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