All Articles from Clement C. Tham -Optical Coherence Tomography News

Articles from Clement C. Tham

1-6 of 6
1. Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis
  
  Explore ScienceDirect Aug 13 2019 Ophthalmology
  
  Background Spectral-domain optical coherence tomography (SDOCT) can be used to detect glaucomatous optic neuropathy, but human expertise in interpretation of SDOCT is limited. We aimed to develop and validate a three-dimensional (3D) deep-learning system using SDOCT volumes to detect glaucomatous optic neuropathy. Methods We retrospectively collected a dataset including 4877 SDOCT volumes of optic disc cube for training (60%), testing (20%), and primary validation (20%) from electronic medical and research records at the Chinese University of Hong Kong Eye Centre (Hong Kong, China) and the Hong Kong Eye Hospital (Hong Kong, China). Residual network was used to build the 3D ...
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  Mentions: Stanford University The Chinese University of Hong Kong University of Hong Kong
2. Unifying Structure Analysis and Surrogate-driven Function Regression for Glaucoma OCT Image Screening
  
  Explore arxiv.org Aug 3 2019 Ophthalmology
  
  Optical Coherence Tomography (OCT) imaging plays an important role in glaucoma diagnosis in clinical practice. Early detection and timely treatment can prevent glaucoma patients from permanent vision loss. However, only a dearth of automated methods has been developed based on OCT images for glaucoma study. In this paper, we present a novel framework to effectively classify glaucoma OCT images from normal ones. A semi-supervised learning strategy with smoothness assumption is applied for surrogate assignment of missing function regression labels. Besides, the proposed multi-task learning network is capable of exploring the structure and function relationship from the OCT image and visual ...
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  Mentions: Chinese Academy of Sciences The Chinese University of Hong Kong
3. Optical Coherence Tomography Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study
  
  Explore Ophthalmology Jul 1 2019 Ophthalmology
  
  Purpose To prospectively determine the relationship of optical coherence tomography angiography (OCTA) metrics to diabetic retinopathy (DR) progression and development of diabetic macular edema (DME). Design: Prospective, observational study. Participants Two hundred and five eyes from 129 patients with diabetes mellitus followed up for at least 2 years. Methods All subjects underwent OCTA with a swept-source OCT (DRI-OCT Triton, Topcon, Inc, Tokyo, Japan). Individual OCTA images of superficial capillary plexus (SCP) and deep capillary plexus (DCP) were generated by IMAGEnet6. After quality check, automated measurements of foveal avascular zone (FAZ) area, FAZ circularity, vessel density (VD) and fractal dimension (FD ...
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  Mentions: Topcon Medical Systems
4. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
  
  Explore ScienceDirect Aug 16 2018 Neurology , Ophthalmology
  
  Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer’s Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD. Methods We conducted a literature search in PubMed and EMBASE to identify studies published before 31 December 2017 ...
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  Mentions: Singapore Eye Research Institute National University of Singapore The Chinese University of Hong Kong
5. Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study
  
  Explore BJO Online Jul 4 2018 Ophthalmology
  
  Aims To evaluate the distributions of quantitative optical coherence tomography angiography (OCT-A) metrics and its associated factors in children. Methods 1059 children aged 6–8 years were recruited from the Hong Kong Children Eye Study. All the participants underwent OCT-A with a swept-source OCT. Retinal microvasculature on superficial capillary plexus was assessed and quantified by a customised automated image analysis programme. Univariable and multiple linear regression analyses were performed to determine systemic (body mass index (BMI), waist circumference, head circumference and blood pressure), demographic and ocular (axial length (AL), macular thickness and volume, retinal nerve fibre layer (RNFL) thickness and ...
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  Mentions: The Chinese University of Hong Kong
6. Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study
  
  Explore BJO Online Jun 9 2018 Ophthalmology
  
  Aim To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients with diabetes, and to compare the strength of associations between BCVA with ICA and other OCT-A metrics. Methods A cross-sectional study involved 447 eyes from 299 patients with diabetes. All participants underwent OCT-A with a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme was used to quantify ICA (the mean of the 10 largest areas including foveal avascular zone (FAZ) area (ICA10_FAZ) and excluding FAZ area (ICA10_excFAZ)) and other OCT-A metrics (FAZ area ...
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  Mentions: The Chinese University of Hong Kong
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