1. Articles from Jessica Wu

    1-2 of 2
    1. Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

      Background/Objectives Choroidal thinning has been suggested in Leber’s hereditary optic neuropathy (LHON). No study has been conducted of the choroid in relation to the retinal ganglion cell-inner plexiform layer (RGC-IPL). We sought to measure choroidal thickness in chronic LHON and to correlate thickness changes with the RGC-IPL. Subjects/Methods Chronic LHON, 11778 mitochondrial DNA (mtDNA) mutation, patients (26 eyes; mean age: 35.1 ± 16.1 years) were prospectively recruited at Doheny Eye Center, University of California Los Angeles from March 2016 to July 2017. Age-matched healthy controls (27 eyes; mean age: 32.4 ± 11.1 years) were enroled ...

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    2. Optical coherence tomography-angiography in Wolfram syndrome: a mitochondrial etiology in disease pathophysiology

      Optical coherence tomography-angiography in Wolfram syndrome: a mitochondrial etiology in disease pathophysiology

      Wolfram syndrome (WS), also known by the acronym DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is an autosomal recessive, progressive neurodegenerative disease. Patients with WS characteristically present with early onset diabetes mellitus and optic atrophy in the first decade of life, 1 diabetes insipidus and deafness in the second decade, and urinary tract with neurological complications in the third decade. WS has been shown to be associated with mutations in the WFS1 or CISD2 (WFS2) gene, probably leading to impaired calcium homeostasis and consequent widespread cellular apoptosis. 2 , 3 Optic atrophy is a constant and profound feature in ...

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    1-2 of 2
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