1. Articles from Thomas B. Connor

    1-2 of 2
    1. Assessing Retinal Structure in Patients with Parkinson Disease

      Assessing Retinal Structure in Patients with Parkinson Disease

      Objective : The retina is an extension of the central nervous system (CNS), and ocular symptoms can precede manifestations of CNS disorders. Given that several neurodegenerative conditions that affect the brain exhibit ocular symptoms, the retina may be an accessible biomarker to monitor disease progression. Dopamine, the key neurotransmitter related to Parkinson’s disease (PD), is contained in amacrine and interplexiform cells, which reside in specific retinal layers. Understanding how loss of dopaminergic cells affects retinal anatomy could be relevant for monitoring disease progression. Here, our objective is to evaluate retinal structure (foveal pit morphology and thickness) in patients with PD ...

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    2. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT images. We demonstrate our technique by performing an ILM peel in ex vivo eyes using low ICG concentrations and laser powers. These results establish the feasibility of PT-OCT for intraoperative ...

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    1-2 of 2
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  2. Topics in the News

    1. (3 articles) University of Washington
    2. (2 articles) University of Wisconsin
    3. (2 articles) Joseph Carroll
    4. (2 articles) Ruikang K. Wang
    5. (1 articles) Vanderbilt University
    6. (1 articles) Yuankai K. Tao
    7. (1 articles) Pooja Godara
    8. (1 articles) Melissa C. Skala
    9. (1 articles) Zhejiang University
    10. (1 articles) Cleveland Clinic
    11. (1 articles) UCSD
    12. (1 articles) Sunil K. Srivastava
    13. (1 articles) Justis P. Ehlers
    14. (1 articles) William R. Freeman
    15. (1 articles) Peng Li
    16. (1 articles) Optovue
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