1. Articles from Pierfrancesco Agostoni

    1-10 of 10
    1. EuOptical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chro

      EuOptical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chro

      Aims: The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. Methods and results: The main PRISON IV trial randomised 330 patients to either SES or EES. At nine months, 281 (85%) patients underwent repeat angiography. Of these, 60 consecutive patients received optical coherence tomography divided over both stent groups. The mean number of struts analysed was 750±337 and 633±358 ...

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    2. Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Aims: The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. Methods and results: The main PRISON IV trial randomised 330 patients to either SES or EES. At nine months, 281 (85%) patients underwent repeat angiography. Of these, 60 consecutive patients received optical coherence tomography divided over both stent groups. The mean number of struts analysed was 750±337 and 633±358 ...

      Read Full Article
    3. Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Aims: The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. Methods and results: The main PRISON IV trial randomised 330 patients to either SES or EES. At nine months, 281 (85%) patients underwent repeat angiography. Of these, 60 consecutive patients received optical coherence tomography divided over both stent groups. The mean number of struts analysed was 750±337 and 633±358 ...

      Read Full Article
    4. SEDUCEd by optical coherence tomography in drug-eluting balloon assessment

      SEDUCEd by optical coherence tomography in drug-eluting balloon assessment

      In everyday practice, percutaneous coronary intervention using a bare metal stent (BMS) is still frequently performed and the chance of incurring in-stent restenosis (ISR) is not negligible. Different treatment modalities for BMS ISR are still an important area of discussion. One of the most appealing is the drug-eluting balloon (DEB). This device has been proven angiographically and clinically superior to an uncoated balloon in BMS ISR1,2. Moreover, in the same type of lesion, DEBs have also shown angiographic and clinical results at least comparable to first-generation drug-eluting stents (DES), with a trend towards lower angiographic restenosis and lower ...

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    5. Diagnostic accuracy of optical coherence tomography parameters in predicting in-stent hemodynamic severe coronary lesions: Validation against fractional flow reserve

      Diagnostic accuracy of optical coherence tomography parameters in predicting in-stent hemodynamic severe coronary lesions: Validation against fractional flow reserve

      Background By means of optical coherence tomography (OCT), coronary dimensions can be assessed accurately. However, whether OCT can identify hemodynamic significant coronary lesions as determined by fractional flow reserve (FFR) in patients with an in-stent lesion is not known. Therefore, we tried to assess the predictive value of OCT parameters in this setting as compared to FFR. Methods and results In patients who underwent a percutaneous coronary intervention for an in-stent restenotic lesion, pre-, post-procedural and 6-month follow-up OCT and FFR acquisitions were performed. In case of an FFR ≤ 0.80, a lesion was classified as hemodynamically severe. Diagnostic efficiency ...

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    6. Optical Coherence Tomography Imaging of Acute Stent Thrombosis After Stentys Stent Implantation

      Optical Coherence Tomography Imaging of Acute Stent Thrombosis After Stentys Stent Implantation

      A 56-year-old man was referred to our catheterization laboratory for percutaneous coronary intervention because of stable angina caused by a stenosis of the proximal left anterior descending coronary artery ( A, Online Video 1 ). The patient was pre-treated with aspirin and clopidogrel and heparin peri-procedural as per routine. After pre-dilation, a Stentys self-expandable drug-eluting stent (Stentys S.A., Paris, France) was placed in the left main coronary artery and proximal left anterior descending coronary artery, followed by post-dilation, with a good angiographic result ( B , Online Video 2 ). Optical coherence tomography revealed an image of a freshly placed stent with uncovered stent ...

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      Mentions: Abbot
    7. Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve

      Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve

      Objectives This study sought to elucidate the underlying mechanism through which drug-eluting balloons (DEB) restore coronary blood flow, by assessing the coronary vessel before, immediately after, and at 6-month follow-up with angiography, optical coherence tomography (OCT), and fractional flow reserve (FFR). Background In-stent restenosis (ISR) treatment remains challenging. Drug-eluting balloons have been shown to be a valid treatment option in several studies. These studies focused on efficiency of the device, whereas the mechanisms of action of DEB in ISR treatment have not been investigated. Methods In this prospective, single-center observational study, patients with ISR were treated with a second-generation DEB ...

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    8. Optical coherence tomography assessment of early stent strut coverage in patients treated with a thin-strut bare cobalt-chromium stent coated with silicon carbide

      Optical coherence tomography assessment of early stent strut coverage in patients treated with a thin-strut bare cobalt-chromium stent coated with silicon carbide

      Although coronary stenting has significantly improved procedural and long-term outcomes in patients undergoing percutaneous coronary intervention (PCI), these procedures are still associated with significant rates of restenosis and thrombosis . Although early stent thrombosis is mainly related to technical aspects of the procedure, many studies have shown that late and very late thrombosis after bare metal stent (BMS) or drug eluting stent (DES) implantation may be related to incomplete endothelialisation and uncovered stent struts . The PRO-Kinetic (Biotronik, Bulach, Switzerland) cobalt-chromium stent is a new generation stent with thin struts (60μm) and a passive coating. These features may reduce restenosis rates as ...

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    9. Optical coherence tomography: new (near-infrared) light on stent implantation?

      Optical coherence tomography (OCT) is an imaging technique, based on near-infrared light, that allows cross-sectional imaging of biological systems. The technique is based on the measurement of optical reflections of biological tissues. An optical signal transmitted through or reflected from a biological tissue contains time-to-flight information which in turn yields spatial information about tissue microstructure (1). While first used in ophthalmology to assess non-invasively the human retina, it has been recently applied to cardiology to allow an invasive visualization of the vessel wall of the coronary arteries from inside the lumen, through a dedicated wire (where the OCT probe is ...
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    1-10 of 10
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    Optical coherence tomography assessment of early stent strut coverage in patients treated with a thin-strut bare cobalt-chromium stent coated with silicon carbide Optical Coherence Tomography Imaging of Acute Stent Thrombosis following Stentys Stent Implantation Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions : Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve Optical Coherence Tomography Imaging of Acute Stent Thrombosis After Stentys Stent Implantation Diagnostic accuracy of optical coherence tomography parameters in predicting in-stent hemodynamic severe coronary lesions: Validation against fractional flow reserve SEDUCEd by optical coherence tomography in drug-eluting balloon assessment Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni EuOptical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chro Assessment of primary open-angle glaucoma peripapillary and macular choroidal area using enhanced depth imaging optical coherence tomography A broken promise: 4-year optical coherence tomography follow-up of a bioresorbable vascular scaffold Factors Affecting Repeatability of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography in Pathologic Eyes