1. Articles from Sanjay Asrani

    1-22 of 22
    1. IDENTIFICATION OF POSTERIOR SEGMENT PATHOLOGY WITH EN FACE RETINAL IMAGING USING MULTICOLOR CONFOCAL SCANNING LASER OPHTHALMOSCOPY

      IDENTIFICATION OF POSTERIOR SEGMENT PATHOLOGY WITH EN FACE RETINAL IMAGING USING MULTICOLOR CONFOCAL SCANNING LASER OPHTHALMOSCOPY

      Purpose: To assess posterior segment findings on multicolor confocal scanning laser ophthalmoscopy by correlation with spectral domain optical coherence tomography (SD-OCT) and to quantify agreement between these imaging modalities. Methods: Retrospective review of 159 eyes of 96 consecutive patients who underwent concurrent imaging with multicolor confocal scanning laser ophthalmoscopy and SD-OCT. Positive percent agreement and negative percent agreement were calculated for each finding identified on infrared, green, blue, and multicolor reflectance images using SD-OCT as a comparator. Results: Infrared reflectance best detected outer retinal and choroidal findings such as choroidal lesions, retinal pigment epithelium atrophy, peripapillary atrophy, and drusen (positive ...

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    2. Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy

      Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy

      Purpose: To compare a novel anterior segment optical coherence tomography (AS-OCT) bleb grading system with a clinical bleb grading system and both with intraocular pressure (IOP) following trabeculectomy surgery. Materials and Methods: A novel AS-OCT grading system based on bleb size and internal reflectivity was developed. An imaging center was tasked with masked grading of AS-OCT images acquired by multiple surgical sites at postoperative week (POW) 2, postoperative month (POM) 4, 6, and 12, respectively. The Moorfields Bleb Grading System was used by another independent imaging center to grade clinical photos. The results of the 2 grading systems were compared ...

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    3. Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy

      Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy

      PURPOSE To compare a novel anterior segment optical coherence tomography (AS-OCT) bleb grading system with a clinical bleb grading system and both with intraocular pressure (IOP) following trabeculectomy surgery. MATERIALS AND METHODS A novel AS-OCT grading system based on bleb size and internal reflectivity was developed. An imaging center was tasked with masked grading of AS-OCT images acquired by multiple surgical sites at postoperative week (POW) 2, postoperative month (POM) 4, 6, and 12, respectively. The Moorfields Bleb Grading System was used by another independent imaging center to grade clinical photos. The results of the 2 grading systems were compared ...

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    4. Normal-Tension Glaucoma Masqueraders: Detection Using Optical Coherence Tomography

      Normal-Tension Glaucoma Masqueraders: Detection Using Optical Coherence Tomography

      Purpose: Optical coherence tomography (OCT) has become an important tool in the diagnosis and management of glaucoma; however, there can be overlap in the OCT findings between glaucoma and other diseases. We describe the clinical examination finings and interpretation of OCT imaging that led to the diagnosis of glaucoma masqueraders in a clinical case series. Materials and Methods: Four adult patients seen in the glaucoma clinic at the Duke Eye Center were included in a retrospective observational case series. Clinical presentation, history, examination, and testing (visual fields, scanning laser ophthalmoscopy, and spectral-domain OCT imaging) were reviewed. Results: We report a ...

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    5. Pitfalls in Optical Coherence Tomography Imaging: Essentials for correct interpretation

      Pitfalls in Optical Coherence Tomography Imaging: Essentials for correct interpretation

      Optical coherence tomography (OCT) is widely used in the diagnosis and detection of glaucomatous progression. Many manufacturers make spectral-domain OCT (SD-OCT) devices, the most widely used type of OCT. In contrast to time-domain OCT, with SD-OCT, a greater area of the retina can be measured without interpolation of data. Additionally, the anterior segment can be imaged using the same machine. Most OCT machines have built-in proprietary software that can measure the peripapillary area as well as the macular region. Most units also have the capability of segmentation analysis, providing data regarding substructures of the retina. These data are presented in ...

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      Mentions: Sanjay G. Asrani
    6. Retinal Nerve Fiber Layer Thickness Measurements

      Retinal Nerve Fiber Layer Thickness Measurements

      Objective To evaluate optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) measurements in patients with active and quiescent uveitis with and without glaucoma and compare results to the published age-adjusted normative data. Design Comparative, retrospective pilot study. Participants Consecutive patients with uveitis who underwent OCT RNFL measurements between December 2011 and October 2012 were identified: 76 uveitic eyes without glaucoma and 135 uveitic eyes with glaucoma. Intervention We conducted OCT of the RNFL. Main Outcome Measures Global and sectoral RNFL thickness measurements. Results In 19 nonglaucomatous, uveitic eyes with active inflammation, mean global and all sectoral RNFL measurements were ...

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    7. Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

      Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

      Importance Spectral-domain optical coherence tomography (SD-OCT) has an integral role in the diagnosis and treatment of glaucoma. Understanding the types of artifacts commonly seen in the imaging of patients being evaluated for glaucoma will help physicians better implement these data in the care of patients. Objectives To determine the frequency and distribution of SD-OCT imaging artifacts in patients being evaluated for glaucoma and to provide examples of common artifacts. Design, Setting, and Participants A retrospective cross-sectional study design was used to examine SD-OCT images (using Spectralis SD-OCT) of 277 consecutive patients who had a diagnosis of glaucoma of any stage ...

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    8. Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain

      Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain

      Background/aims Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma and determine its agreement with TD-OCT. Methods Children who had SD-OCT(Spectralis, Heidelberg-Engineering,Germany) were retrospectively and prospectively identified from Duke paediatric glaucoma clinic. The peripapillary retinal nerve fibre layer (RNFL) and macular thickness and volume (MV) were compared amongst four groups: normal eyes, eyes with physiologic cupping (C:D >0.5 and <0.8, IOP <21), mild glaucomatous eyes (C:D ...

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    9. Beyond the Retinal Nerve Fiber Layer: What are the New Approaches in 2012?

      Beyond the Retinal Nerve Fiber Layer: What are the New Approaches in 2012?

      Glaucoma diagnosis with imaging devices is difficult because of the variation in axonal count amongst normals. The convergence point of all axons is the optic nerve head and peripapillary retinal nerve fiber layer (RNFL). However, a majority of the ganglion cells (from which the RNFL originates) reside in the macula (40% of the retinal thickness) and since their numbers are relatively constant amongst normals 1, it may be another valuable measurement.

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    10. Glaucoma Masqueraders: Diagnosis by spectral domain Optical Coherence Tomography

      Glaucoma Masqueraders: Diagnosis by spectral domain Optical Coherence Tomography

      Background Advances in optic nerve and retinal imaging have dramatically changed the care of glaucoma patients, complementing the importance of the clinical exam of the optic nerve and automated perimetry in making the diagnosis of glaucoma. Computerized imaging, however, does not replace the clinical exam, as there can be overlap in the appearance of non-glaucomatous optic neuropathies with glaucoma. Methods The spectral domain optic coherence tomography (SD-OCT) images of five patients with non-glaucomatous optic nerve pathology are presented. Cases The first patient had bilateral temporal thinning on OCT imaging and subsequent positive syphilis testing. The second patient had a glaucomatous-appearing ...

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    11. Novel Software Strategy for Glaucoma Diagnosis: Asymmetry Analysis of Retinal Thickness

      Novel Software Strategy for Glaucoma Diagnosis: Asymmetry Analysis of Retinal Thickness
      The benefits of high-speed, detailed retinal thickness measurement by spectral-domain optical coherence tomography in glaucoma diagnosis have not been fully realized. We have modified the software protocols for such measurement and applied it for diagnosis at different stages of glaucoma. Using the Spectralis SD-OCT (Heidelberg Engineering, Carlsbad, California), we have customized the retinal thickness protocol to acquire detailed retinal thickness measurements of the central 20° of the posterior pole. These custom maps are displayed in a compressed color scale that reveals small losses in retinal thickness. A novel asymmetry analysis protocol was created to highlight differences between the eyes and ...
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    12. Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios

      Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios
      Children with large optic nerve head cups often pose diagnostic difficulty due to concern over possible glaucoma. This study's purpose was to evaluate optical coherence tomography (OCT) measurement of the peripapillary retinal nerve fiber layer (RNFL) and macular thickness in healthy eyes of black and white children, comparing values for eyes with large cup-to-disc ratios against those with small cup-to-disc ratios (normal controls). Using Stratus OCT (OCT 3) (Carl Zeiss Meditec, Dublin, CA) a fast macular thickness and fast RNFL 3.4 protocol were performed on normal eyes of normal children. Included were children (aged 5-17 years) with normal ...
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    13. Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography

      Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography
      Abstract: Background: In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiating glaucomatous from non-glaucomatous optic nerve cupping in a cross-sectional pilot study. Methods: Eleven consecutive patients presenting to the Duke Eye Center from September 2007 to July 2008 with nonglaucomatous optic nerve cupping and 12 patients with glaucomatous optic nerve cupping were identified. All patients underwent Stratus® OCT imaging: fast macular map, fast retinal nerve fiber layer (RNFL) 3.4 thickness, and fast optic disc ...
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    14. Reproducibility of OCT in children with glaucoma

      Introduction: Optical Coherence Tomography(OCT) has been proven to be a useful clinical tool in the follow-up of adult glaucoma(IOVS2008;49:4886-4892.). Its use in pediatric glaucoma is limited because reproducibility has been assessed only in normal children and on the same visit (AJO,2007;143:484–488). This study's purpose is to evaluate the reproducibility of OCT in children with stable glaucoma in a clinical setting.
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    15. Subclinical foveal hypoplasia in normal children detected by OCT

      Introduction: Foveal hypoplasia is usually associated with significant visual dysfunction and an absent foveal reflex on biomicroscopy. Optical coherence tomography(OCT) easily provides accurate images of the foveal anatomy. Among a group of normal children having OCT for the development of a normative database (Arch Ophthalmol 2009;127), we identified a few with underdeveloped foveal architecture despite normal clinical examination. This study's purpose is to characterize the prevalence and features of subclinical foveal hypoplasia in the eyes of normal children.
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    16. Optical Coherence Tomography Errors in Glaucoma

      Purpose: To demonstrate the types and prevalence of errors associated with the use of optical coherence tomography in a cross section of glaucoma patients. The association of different types of artifacts and certain coexisting ocular diagnoses was also evaluated. Patients and Methods: The optical coherence tomography data of glaucoma patients in a 3-month period was evaluated for evidence of errors in peripapillary retinal nerve fiber layer (RNFL) map and the macular thickness map. Signal strengths, centering errors, individual scan errors, and association with ocular conditions were noted. Logistic regression was used to assess the significance of continuous and categorical variables ...
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    17. Correlation between Optical Coherence Tomography and glaucomatous optic nerve head damage in children

      Purpose: To compare analysis of macular and nerve fiber layer thickness by optical coherence tomography (OCT), to optic nerve head (ONH) morphology based upon stereophotography. Design: Prospective observational case control series. Methods: Normal and glaucomatous eyes of children (age 4-17 years) were scanned using Stratus OCT (Carl Zeiss Meditec, Dublin, CA). Fast macular and retinal nerve fiber layer (RNFL) thickness map were performed on 372 eyes of 222 children. ONH stereophotographs were taken and evaluated by two masked observers, using a grading system of 0 to 5 based on both cupping ratio and morphology. OCT3 analyses were compared across ONH ...
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    18. Detailed Visualization of the Anterior Segment Using Fourier-Domain Optical Coherence Tomography

      Objective To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. Methods A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study. Results Schlemm’s canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures ...
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    19. Detailed Visualization of the Anterior Segment Using Fourier-Domain Optical Coherence Tomography

      Objective  To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. Methods  A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study. Results  Schlemm’s canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures ...
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    20. Imaging the Ocular Anterior Segment With Real-Time, Full-Range Fourier-Domain Optical Coherence Tomography

      We have demonstrated a novel Fourier-domain optical coherence tomography system and signal-processing algorithm for full-range, real-time, artifact-free quantitative imaging of the anterior chamber. Cross-sectional full-range images comprising 1024 x 800 pixels (axial x lateral) were acquired and displayed at 6.7 images/s. Volumetric data comprising 1024 x 400 x 60 pixels (axial x lateral x elevation) were acquired in 4.5 seconds with real-time visualization of individual slices and 3-dimensional reconstruction performed in postprocessing. Details of the cornea, limbus, iris, anterior lens capsule, trabecular meshwork, and Schlemm's canal were visualized. Quantitative surface height maps of the corneal epithelium ...
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    1-22 of 22
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    1. (21 articles) Sanjay G. Asrani
    2. (20 articles) Duke University
    3. (6 articles) Sharon F. Freedman
    4. (3 articles) University of Washington
    5. (3 articles) Marinko V. Sarunic
    6. (3 articles) Joseph A. Izatt
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    Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios Novel Software Strategy for Glaucoma Diagnosis: Asymmetry Analysis of Retinal Thickness Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma Normal Reference Ranges of Optical Coherence Tomography Parameters in Children Optical coherence tomography angiography using the black-and-white pixel binarization histogram software: a new technique for evaluating healing of macular holes in two surgical techniques B-Scan Attentive CNN for the Classification of Retinal Optical Coherence Tomography Volumes The protective effect of astaxanthin on the ganglion cell complex in glutamate/aspartate transporter deficient mice, a model of normal tension glaucoma, analyzed by spectral domain-optical coherence tomography Small Symptomatic Unilateral Choroidal Osteoma Diagnosed with Enhanced-Depth Imaging Optical Coherence Tomography and Thin-Slice Computed Tomography: 2 Clinical Cases Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography Technology in Practical Dermatology (Textbook) Optic Nerve Head Parameters and Macular Thickness Analysis by Optical Coherence Tomography in Presenile Patients After Cataract Surgery