1. Articles from Farouc A. Jaffer

    1-13 of 13
    1. SCAI Position Statement on Optimal Percutaneous Coronary Interventional Therapy for Complex Coronary Artery Disease

      SCAI Position Statement on Optimal Percutaneous Coronary Interventional Therapy for Complex Coronary Artery Disease

      The anatomic and clinical complexity of patients with coronary artery disease (CAD) is increasing in the United States. 1 - 3 While the terms “complex CAD” or “high‐risk CAD” have not been formally defined, they encompass both complex anatomic lesions and clinical parameters including advanced age, frailty, comorbidities, compromised hemodynamic status, depressed ventricular function and concomitant valvular disease. 4 - 6 Such features increase both the procedural complexity of percutaneous coronary intervention (PCI) and the risk of adverse patient outcomes. The direct relationship between CAD complexity and the appropriateness for coronary revascularization is also emphasized in current societal guidelines and appropriate ...

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    2. 3D cellular-resolution imaging in arteries using few-mode interferometry

      3D cellular-resolution imaging in arteries using few-mode interferometry

      Article Open Access Published: 21 November 2019 3D cellular-resolution imaging in arteries using few-mode interferometry Biwei Yin , Zhonglie Piao , Kensuke Nishimiya , Chulho Hyun , Joseph A. Gardecki , Adam Mauskapf , Farouc A. Jaffer & Guillermo J. Tearney Light: Science & Applications volume 8 , Article number: 104 ( 2019 ) Cite this article Article metrics 3 Altmetric Metrics details Abstract Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant, as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent manner. However, due to the inherent resolution-depth of focus tradeoff of conventional focusing optics, today ...

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    3. Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank

      Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank

      The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture held annually, bringing together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community. During the SCAI 2019 Scientific Sessions, relevant topics in interventional cardiology were identified with the goals of defining the state of the field, current challenges, and future directions. Topics were determined by nomination, and solidified through a voting process ultimately vetted by SCAI leadership and the industry relations committee. The 2019 Think Tank was organized into four parallel sessions reflective of the field of interventional cardiology: (a) coronary intervention, (b ...

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      Mentions: FDA
    4. Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap

      Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap

      Coronary artery disease remains a leading cause of mortality worldwide, primarily through acute events mediated by progression and disruption of thrombosis-provoking atheroma. The necrotic core of advanced atheroma harbors highly prothrombotic material, including components of tissue factor, von Willebrand factor, and plasminogen activator inhibitor–1. Exposure of these contents to flowing blood can spur thrombosis and is a critical feature of many acute coronary syndromes (ACS). It is therefore vital that the fibrous cap, a collagen-rich structure overlying advanced atheroma, resist disruption and maintain separation of blood from thrombogenic necrotic cores. Intravascular imaging using intravascular ultrasound (IVUS) and optical coherence ...

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    5. Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis

      Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis

      Objectives This study sought to determine whether indocyanine green (ICG)–enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. Background New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administration–approved NIRF imaging agent that experimentally targets plaque macrophages and lipid in areas of enhanced endothelial permeability. However, it is unknown whether ICG can target atheroma in patients. Methods Eight patients were enrolled in the BRIGHT-CEA (Indocyanine Green ...

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    6. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular ...

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    7. Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

      Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

      Objectives We present the clinical imaging of human coronary arteries in vivo using a multimodality optical coherence tomography (OCT) and near-infrared autofluorescence (NIRAF) intravascular imaging system and catheter. Background Although intravascular OCT is capable of providing microstructural images of coronary atherosclerotic lesions, it is limited in its capability to ascertain the compositional/molecular features of plaque. A recent study in cadaver coronary plaque showed that endogenous NIRAF is elevated in necrotic core lesions. The combination of these 2 technologies in 1 device may therefore provide synergistic data to aid in the diagnosis of coronary pathology in vivo. Methods We developed ...

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    8. Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo

      Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo

      Aims Fibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing stent tissue coverage as a measure of healed stents, but cannot precisely identify whether overlying tissue represents physiological neointima. Here we assessed and compared fibrin deposition and persistence on bare metal stent (BMS) and drug-eluting stent (DES) using near-infrared fluorescence (NIRF) molecular imaging in vivo, in combination with simultaneous OCT stent coverage. Methods and results Rabbits underwent implantation of one BMS and one DES without overlap in the infrarenal aorta ( N = 20 3.5 ...

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    9. Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging

      Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging

      Intravascular optical coherence tomography (IVOCT) is a well-established method for the high-resolution investigation of atherosclerosis in vivo. Intravascular near-infrared fluorescence (NIRF) imaging is a novel technique for the assessment of molecular processes associated with coronary artery disease. Integration of NIRF and IVOCT technology in a single catheter provides the capability to simultaneously obtain co-localized anatomical and molecular information from the artery wall. Since NIRF signal intensity attenuates as a function of imaging catheter distance to the vessel wall, the generation of quantitative NIRF data requires an accurate measurement of the vessel wall in IVOCT images. Given that dual modality, intravascular ...

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    10. Shining Light and Illuminating Murine Atherosclerosis via Optical Coherence Tomography

      Shining Light and Illuminating Murine Atherosclerosis via Optical Coherence Tomography

      In vivo visualization and quantification of plaque burden and plaque macrophages are major goal in the field of atherosclerosis imaging, particularly in highly utilized mouse models of atherosclerosis. Thus far, vascular MRI has demonstrated the ability to quantify and track murine atherosclerosis at moderate resolution.1,2 In addition, molecular imaging approaches have illuminated plaque macrophages in vivo.3,4 However, only a few approaches, such as intravital fluorescence microscopy, have provided high-resolution (<100 micrometer) imaging of plaque macrophages in murine atherosclerosis.5,6 Intravital fluorescence microscopy imaging, however, is limited by light penetration and is also impractical to use for comprehensive aortic imaging, a major zone of atherosclerosis in genetically altered mice.

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    11. Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

      Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

      Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for ...

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    12. Intravascular Optical Imaging Technology for Investigating the Coronary Artery

      Intravascular Optical Imaging Technology for Investigating the Coronary Artery
      There is an ever-increasing demand for new imaging methods that can provide additional information about the coronary wall to better characterize and stratify high-risk plaques, and to guide interventional and pharmacologic management of patients with coronary artery disease. While there are a number of imaging modalities that facilitate the assessment of coronary artery pathology, this review paper focuses on intravascular optical imaging modalities that provide information on the microstructural, compositional, biochemical, biomechanical, and molecular features of coronary lesions and stents. The optical imaging modalities discussed include angioscopy, optical coherence tomography, polarization sensitive-optical coherence tomography, laser speckle imaging, near-infrared spectroscopy, time-resolved ...
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    13. Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis

      Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis
      Abstract—Imaging approaches that visualize molecular targets rather than anatomic structures aim to illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several such molecular imaging strategies are poised for rapid clinical application. This review describes the growing role of in vivo optical molecular imaging in atherosclerosis and highlights its ability to visualize atheroma inflammation, calcification, and angiogenesis. In addition we discuss advances in multimodality probes, both in the context of multimodal imaging as well as multifunctional, or "theranostic," nanoparticles. This review highlights particular molecular imaging strategies that possess strong potential for clinical translation.
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    1-13 of 13
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  2. Topics in the News

    1. (11 articles) Harvard University
    2. (11 articles) Massachusetts General Hospital
    3. (8 articles) Guillermo J. Tearney
    4. (4 articles) Massachusetts Institute of Technology
    5. (4 articles) Ali M. Fard
    6. (4 articles) Giovanni J. Ughi
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    Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis Intravascular Optical Imaging Technology for Investigating the Coronary Artery Shining Light and Illuminating Murine Atherosclerosis via Optical Coherence Tomography Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank Combining Deep Learning With Optical Coherence Tomography Imaging to Determine Scalp Hair and Follicle Counts Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma