1. Articles from Rosalia Dettori

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    1. Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome

      Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome

      Both plaque macrophage infiltration [1] and calcification [2] are recently suggested characteristics of plaque vulnerability in coronary lesions. Each of these two morphologic characteristics may foster the other. [3, 4]. Thus, the aim herein, is to evaluate this interdependence using optical coherence tomography (OCT), which, due to its supreme resolution, has the ability to detect both features. A recent study defined colocalization of macrophages and calcification (ColocCaMa) as a distance < 100 µm between plaque macrophages and calcification. In this work an association was described between ColocCaMa and the more heavily calcified, but also less advanced and more vulnerable coronary lesions ...

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    2. Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study

      Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study

      Background Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcification angle (ICA) as the angle externally projected by a vascular calcification and analyzed its role as novel feature of coronary plaque vulnerability in patients with type 2 diabetes. Methods Optical coherence tomography was used to determine ICA in 219 calcifications from 56 patients with stable coronary artery disease (CAD) and 143 calcifications from 36 patients with acute coronary syndrome (ACS). We then used finite elements analysis to gain mechanistic insight into ...

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    3. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study

      Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study

      Background The minimal fibrous cap thickness overlying the necrotic lipid core as well as the presence of macrophages are established characteristics of coronary plaque vulnerability. Recently, the presence of microcalcifications has emerged as a novel feature of vulnerable lesions. However, clinical and plaque morphological predictors of microcalcifications are unknown. Methods In patients with stable coronary artery disease, analysis of plaque morphology ( n  = 112) was performed using optical coherence tomography prior to coronary intervention to assess predictors of microcalcifications. Results Microcalcifications were present in 21/112 (18.7%) lesions. Segments with microcalcifications showed a higher total number of calcifications per lesion ...

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    1-3 of 3
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    1. (6 articles) National Institutes of Health
    2. (3 articles) Mathias Burgmaier
    3. (2 articles) RWTH Aachen University
    4. (2 articles) UC Irvine
    5. (2 articles) Oregon Health & Science University
    6. (2 articles) Zhongping Chen
    7. (2 articles) Yifan Jian
    8. (2 articles) Heidelberg Engineering
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    Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome The Effect of Anti-Tubercular Drugs on Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography. OCT angiography improves views of retina blood flow Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning Baylor College of Medicine Receives a 2020 NIH Grant for Biomechanics of Early Mammalian Cardiogenesis University of Houston Receives a 2020 NIH Grant for Biomechanics of Neural Tube Development using Brillouin-OCT Multimodality Oregon Health and Sciences University Receives a 2020 NIH Grant  for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity UC Irvine Receives a 2020 NIH Grant for In Vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology