1. Articles from Daniel A. Gil

    1-3 of 3
    1. Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Optical coherence tomography (OCT) is an emerging technology for in vivo< airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary information to OCT for airway and lung imaging. We demonstrate OCT and RI of respiratory ciliated epithelial function in ex vivo mouse tracheae. We applied RI to measure cellular metabolism ...

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    2. Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia

      Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia

      Efficient mucociliary clearance is necessary to protect the respiratory tract from infection. Mucociliary dysfunction is common in respiratory diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Rescuing mucociliary clearance by stimulating the metabolism of respiratory ciliated epithelia could offer new treatments for respiratory diseases. However, the coupling between cellular metabolism and mechanical output in respiratory ciliated epithelia is poorly understood. We propose to study this coupling with autofluorescence microscopy and optical coherence tomography (OCT), to measure cellular metabolism and ciliary motility, respectively. The autofluorescent metabolic co-enzymes NAD(P)H and FAD provide non-invasive measures of metabolism through the ...

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    3. Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

      Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

      Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible and near-infrared OCT image analysis demonstrated increased scattering coefficients ( μ s ) in ablated versus normal tissues (Vis: 347.8%, NIR: 415.0%) and shows the potential for both wavelength ranges to ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Melissa C. Skala
    2. (2 articles) University of Wisconsin
    3. (2 articles) Yale University
    4. (2 articles) Michael A. Choma
    5. (1 articles) Vanderbilt University
    6. (1 articles) Thorlabs
    7. (1 articles) Universität Rostock
    8. (1 articles) Duke University
    9. (1 articles) L V Prasad Eye Institute
    10. (1 articles) VU University Amsterdam
    11. (1 articles) University of Leipzig
    12. (1 articles) Johannes F. de Boer
    13. (1 articles) Felipe A. Medeiros
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    Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia Redox imaging and optical coherence tomography of the respiratory ciliated epithelium Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography A Method for the Assessment of Textile Pilling Tendency Using Optical Coherence Tomography Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study OCT (optical coherence tomography) contribution assessment in the revascularisation of long femoro-popliteal occlusive lesions (TASC C and D): a randomised trial The Effect of Anti-Tubercular Drugs on Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review