1. Articles from Mikkel Jensen

    1-8 of 8
    1. Feature Of The Week 04/28/2019: Real-Time High-Resolution Mid-Infrared OCT

      Feature Of The Week 04/28/2019: Real-Time High-ResolutionMid-Infrared OCT

      The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4 µm and an axial resolution of 8.6 µm is demonstrated. The system produces two-dimensional cross-sectional images ...

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    2. Noise of supercontinuum sources in spectral domain optical coherence tomography

      Noise of supercontinuum sources in spectral domain optical coherence tomography

      In this paper, we investigate the effect of pulse-to-pulse fluctuations of supercontinuum sources on the noise in spectral domain optical coherence tomography (OCT) images. The commonly quoted theoretical expression for the OCT noise is derived for a thermal light source, which is not suitable if a supercontinuum light source is used. We therefore propose a new, measurement-based OCT noise model that predicts the noise without any assumptions on the type of light source. We show that the predicted noise values are in excellent agreement with the measured values. The spectral correlation evaluated for the photodetected signal when using a supercontinuum ...

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    3. Real-time high-resolution mid-infrared optical coherence tomography

      Real-time high-resolution mid-infrared optical coherence tomography

      The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4 µm and an axial resolution of 8.6 µm is demonstrated. The system produces two-dimensional cross-sectional images ...

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    4. Real‐time High‐Resolution Mid‐infrared Optical Coherence Tomography

      Real‐time High‐Resolution Mid‐infrared Optical Coherence Tomography

      The potential for improving the penetration depth of optical coherence tomography systems by using increasingly longer wavelength light sources has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid‐infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid‐infrared spectral‐domain optical coherence tomography system operating at 4 µm central wavelength with an axial resolution of 8.6 µm is demonstrated. The system produces 2D cross ...

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    5. Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

      Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

      Optical coherence tomography (OCT) is an optical imaging technology that enables real time, high‐resolution, cross‐sectional and en face investigation of skin by detecting reflected broad‐spectrum near‐infrared light from tissue. OCT provides micron‐scale spatial resolution and millimeter‐scale depth of penetration [1]. Several commercial OCT systems with handheld probes targeted for Dermatology are now available [2].

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    6. In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography

      In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography

      The human skin is comprised by two layers; epidermis and dermis, separated by the dermo-epidermal junction (DEJ). The relevance of depicting DEJ and measurement of the epidermal thickness (ET) is e.g. seen for superficial skin cancers where delineation of DEJ is of prime prognostic importance. Another example is diagnosis of psoriasis where a thickened epidermis and a ridged DEJ is a hallmark. Histopathological examination of biopsied tissue is traditionally performed to trace DEJ and measure ET. An efficient and precise method to locate DEJ and measure ET is optical coherence tomography (OCT) which is an in vivo and non-invasive ...

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    7. Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis

      Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis

      Optical coherence tomography (OCT) is an optical imaging technology that enables real time, highresolution, cross-sectional and en face investigation of skin by detecting reflected broad-spectrum near-infrared light from tissue. OCT provides micron-scale spatial resolution and millimeter-scale depth of penetration [1]. Several commercial OCT systems with handheld probes targeted for Dermatology are now available [2]. The ability of OCT to achieve high diagnostic accuracy in skin diseases is hampered by the fact that not all diseases show sufficient contrast to be discriminated from normal skin. The challenge in realizing contrast enhancement in OCT imaging is to achieve signal from exogenous contrast ...

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    8. All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations

      All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations

      In ultra-high resolution (UHR-) optical coherence tomography (OCT) group velocity dispersion (GVD) must be corrected for in order to approach the theoretical resolution limit. One approach promises not only compensation, but complete annihilation of even order dispersion effects, and that at all sample depths. This approach has hitherto been demonstrated with an experimentally demanding ’balanced detection’ configuration based on using two detectors. We demonstrate intensity correlation (IC) OCT using a conventional spectral domain (SD) UHR-OCT system with a single detector. IC-SD-OCT configurations exhibit cross term ghost images and a reduced axial range, half of that of conventional SD-OCT. We demonstrate ...

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    1-8 of 8
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    All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis Real‐time High‐Resolution Mid‐infrared Optical Coherence Tomography Real-time high-resolution mid-infrared optical coherence tomography Noise of supercontinuum sources in spectral domain optical coherence tomography Feature Of The Week 04/28/2019: Real-Time High-ResolutionMid-Infrared OCT Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation Novel optical coherence tomography findings in idiopathic choroidal folds