1. Articles from Jürgen Popp

    1-4 of 4
    1. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm to the patient. Nowadays, optical modalities, such as optical coherence tomography (OCT) and Raman spectroscopy (RS), have proven to detect cancer in real time and can provide more detailed clinical ...

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    2. Toward an All-Optical Biopsy

      Toward an All-Optical Biopsy

      Combining multiple photonic imaging techniques could allow for new, noninvasive approaches to tumor detection and assessment, meeting clinical challenges at a time of rising global cancer incidence. [Getty Images] A compact experimental setup for multimodal nonlinear microscopy in clinical settings. [Leibniz-IPHT, S. Döring] Aging populations, exposure to environmental contamination in developing countries, and other factors are driving significant increases in cancer worldwide. The World Health Organization estimates that globally, the number of cancer cases will reach 21.6 million by 2030, nearly double the 14 million patients in 2012. In Germany alone, malignant tumors are responsible for a quarter ...

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    3. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder wall for suspicious lesions with the ability to discriminate malignant tissue from healthy urothelium. Upon identification of degenerated tissue via OCT, RS was implemented to determine the molecular characteristics via ...

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    4. Detection and characterization of early plaque formations by Raman probe spectroscopy and optical coherence tomography: an in vivo study on a rabbit model

      Detection and characterization of early plaque formations by Raman probe spectroscopy and optical coherence tomography: an in vivo study on a rabbit model

      Intravascular imaging techniques provide detailed specification about plaque appearance and morphology, but cannot deliver information about the biochemical composition of atherosclerotic plaques. As the biochemical composition is related to the plaque type, important aspects such as the risk of a plaque rupture and treatment are still difficult to assess. Currently, various spectroscopic techniques are tested for potential applications for the chemical analysis of plaque depositions. Here, we employ Raman spectroscopy in combination with optical coherence tomography (OCT) for the characterization of plaques on rabbits in vivo . Experiments were carried out on New Zealand white rabbits treated with a fat- and ...

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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) National Institutes of Health
    2. (2 articles) Medical University of Vienna
    3. (2 articles) Wolfgang Drexler
    4. (2 articles) Rainer A. Leitgeb
    5. (2 articles) Harvard University
    6. (2 articles) Northwestern University
    7. (1 articles) University of Copenhagen
    8. (1 articles) University of Freiburg
    9. (1 articles) Peter E. Andersen
    10. (1 articles) Angelika Unterhuber
    11. (1 articles) Marco Andreanea
    12. (1 articles) Ryan Sentosa
    13. (1 articles) Mikael Timo Erkkilä
    14. (1 articles) University of Southern California
    15. (1 articles) Texas A&M University
    16. (1 articles) FDA
    17. (1 articles) Dresden University of Technology
    18. (1 articles) Edmund Koch
    19. (1 articles) Lars Kirsten
    20. (1 articles) Javier A. Jo
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    Detection and characterization of early plaque formations by Raman probe spectroscopy and optical coherence tomography: an in vivo study on a rabbit model Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer Toward an All-Optical Biopsy Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop Medical treatment of inflammatory punctual stenosis monitored by anterior segment optical coherence tomography Development and Validation of a Deep Learning System for Diagnosing Glaucoma Using Optical Coherence Tomography Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure Mathematical Analysis of Texture Indicators for the Segmentation of Optical Coherence Tomography Images Comparison of Current Optical Coherence Tomography Angiography Methods in Imaging Retinal Hemangioblastomas New findings useful for clinical practice using swept-source optical coherence tomography angiography in the follow-up of active ocular toxoplasmosis Ultrafast-laser ablation of polymer multicore fibers enhances biomedical sensing