1. Articles from Kathrin Burgmaier

    1-3 of 3
    1. Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome

      Colocalization of plaque macrophages and calcification in coronary plaques as detected by optical coherence tomography predicts cardiovascular outcome

      Both plaque macrophage infiltration [1] and calcification [2] are recently suggested characteristics of plaque vulnerability in coronary lesions. Each of these two morphologic characteristics may foster the other. [3, 4]. Thus, the aim herein, is to evaluate this interdependence using optical coherence tomography (OCT), which, due to its supreme resolution, has the ability to detect both features. A recent study defined colocalization of macrophages and calcification (ColocCaMa) as a distance < 100 µm between plaque macrophages and calcification. In this work an association was described between ColocCaMa and the more heavily calcified, but also less advanced and more vulnerable coronary lesions ...

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    2. Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study

      Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study

      Background Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcification angle (ICA) as the angle externally projected by a vascular calcification and analyzed its role as novel feature of coronary plaque vulnerability in patients with type 2 diabetes. Methods Optical coherence tomography was used to determine ICA in 219 calcifications from 56 patients with stable coronary artery disease (CAD) and 143 calcifications from 36 patients with acute coronary syndrome (ACS). We then used finite elements analysis to gain mechanistic insight into ...

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    3. Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study

      Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study

      Background Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this study aimed to compare differences of coronary plaque morphology in patients with and without T2DM with a particular focus on coronary calcification. Methods In 91 patients (T2DM = 56, non-T2DM = 35 ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Mathias Burgmaier
    2. (2 articles) RWTH Aachen University
    3. (1 articles) Jikei University School of Medicine
    4. (1 articles) Macquarie University
    5. (1 articles) Medical University of Vienna
    6. (1 articles) University of Florence
    7. (1 articles) National Institutes of Health
    8. (1 articles) Beth Israel Deaconess Medical Center
    9. (1 articles) Giacomo Savini
    10. (1 articles) Bernhard Baumann
    11. (1 articles) Antonia Lichtenegger
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