1. Articles from Pouya Jelvehgaran

    1-3 of 3
    1. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

      Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

      Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a ...

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    2. Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

      Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

      Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10  μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4.0, 10.0, 16.0, and 20.0 Gy on 5.0-mm spots, spaced 10.0 mm apart in the esophagus. They were repeatedly imaged using ...

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    3. Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study

      Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study

      Purpose Optical coherence tomography (OCT) is of interest to visualize microscopic esophageal tumor extensions to improve tumor delineation for radiation therapy (RT) planning. Fiducial marker placement is a common method to ensure target localization during planning and treatment. Visualization of these fiducial markers on OCT permits integrating OCT and computed tomography (CT) images used for RT planning via image registration. We studied the visibility of 13 (8 types) commercially available solid and liquid fiducial markers in OCT images at different depths using dedicated esophageal phantoms and evaluated marker placement depth in clinical practice. Materials and Methods We designed and fabricated ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Academic Medical Center at the University of Amsterdam
    2. (3 articles) Ton G. van Leeuwen
    3. (3 articles) Daniël M. de Bruin
    4. (3 articles) Johannes F. de Boer
    5. (2 articles) VU University Amsterdam
    6. (1 articles) Dirk J. Faber
    7. (1 articles) Soochow University
    8. (1 articles) The Chinese University of Hong Kong
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    Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study Effect Of Optic Disk—Fovea Distance On Measurements Of Individual Macular Intraretinal Layers In Normal Subjects Boston Medical Center Receives NIH Grant for Eye To Brain: Eye Biomarkers and Cognition Best Clinical Practice for Age-Related Macular Degeneration Imaging Optical Coherence Tomography Angiography Findings in Fabry Disease Appearance of Polypoidal Lesions in Patients With Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomographic Angiography Measurement of Vessel Density Using Optical Coherence Tomography-angiography in Normal Subjects: Difference by Analysis Area Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography Collateral Vessels in Branch Retinal Vein Occlusion: Anatomic and Functional Analyses by Optical Coherence Tomography Angiography Restenosis of a Polytetrafluoroethylene-Covered Stent Visualized by Coronary Angioscopy and Optical Coherence Tomography: A Case Report