1. Articles from Maxime Descoteaux

    1-2 of 2
    1. Fully automated dual-resolution serial optical coherence tomography aimed at diffusion MRI validation in whole mouse brains

      Fully automated dual-resolution serial optical coherence tomography aimed at diffusion MRI validation in whole mouse brains

      An automated dual-resolution serial optical coherence tomography (2R-SOCT) scanner is developed. The serial histology system combines a low-resolution (25  μm  /  voxel) 3  ×   OCT with a high-resolution (1.5  μm  /  voxel) 40  ×   OCT to acquire whole mouse brains at low resolution and to target specific regions of interest (ROIs) at high resolution. The 40  ×   ROIs positions are selected either manually by the microscope operator or using an automated ROI positioning selection algorithm. Additionally, a multimodal and multiresolution registration pipeline is developed in order to align the 2R-SOCT data onto diffusion MRI (dMRI) data acquired in the same ex vivo mouse brains ...

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    2. Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI

      Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI

      An automated massive histology setup combined with an optical coherence tomography (OCT) microscope was used to image a total of n = 5 n=5 whole mouse brains. Each acquisition generated a dataset of thousands of OCT volumetric tiles at a sampling resolution of 4.9 × 4.9 × 6.5    μ m 4.9×4.9×6.5  μm . This paper describes techniques for reconstruction and segmentation of the sliced brains. In addition to the measured OCT optical reflectivity, a single scattering photon model was used to compute the attenuation coefficients within each tissue slice. Average mouse brain templates were generated for ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) Polytechnique Montreal
    2. (2 articles) Frédéric Lesage
    3. (1 articles) University of Montreal
    4. (1 articles) Sun Yat-Sen University
    5. (1 articles) National Institutes of Health
    6. (1 articles) University of Illinois at Urbana-Champaign
    7. (1 articles) Tianjin University
    8. (1 articles) Zhejiang University
    9. (1 articles) New York Eye and Ear Infirmary
    10. (1 articles) Eric J. Chaney
    11. (1 articles) Jun Zhang
    12. (1 articles) Robert Ritch
    13. (1 articles) Stephen A. Boppart
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