1. Articles from Anthony J. Deegan

    1-9 of 9
    1. Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Background: The visual assessment of burned skin is inherently subjective, and whilst a number of imaging modalities have identified quantifiable parameters to characterize vascular and structural changes following burn damage, none have become common place in the assessment protocol. Here, we use optical coherence tomography (OCT)-based angiography (OCTA) to introduce novel correlations between vessel depth, i.e., the depth of functional blood vessels beneath the tissue surface, edema depth, i.e., the depth of interstitial fluid buildup beneath the tissue surface, and tissue injury depth, i.e., the depth of collagen denaturation beneath the tissue surface, following burn injury ...

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    2. Microvascular imaging of the skin

      Microvascular imaging of the skin

      Despite our understanding that the microvasculature plays a multifaceted role in the development and progression of various conditions, we know little about the extent of this involvement. A need exists for non-invasive, clinically meaningful imaging modalities capable of elucidating microvascular information to aid in our understanding of disease, and to aid in the diagnosis/monitoring of disease for more patient-specific care. In this review article, a number of imaging techniques are summarized that have been utilized to investigate the microvasculature of skin, along with their advantages, disadvantages and future perspectives in preclinical and clinical settings. These techniques include dermoscopy, capillaroscopy ...

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    3. Mapping and Quantitating Penetrating Vessels in Cortical Brain Using Eigen-Decomposition of OCT Signals and Subsequent Principal Component Analysis

      Mapping and Quantitating Penetrating Vessels in Cortical Brain Using Eigen-Decomposition of OCT Signals and Subsequent Principal Component Analysis

      Penetrating vessels bridge the mesh of communicating vessels on the surface of the cortex with the subsurface microvascular beds that feed the underlying neural tissue. Their accurate identification in vivo is important in the investigations of neural degenerative diseases, e.g., Alzheimer's disease and stroke. Here, we propose an efficient method to automatically map cortical penetrating vessels based on an eigen decompensation analysis of the optical coherence tomography (OCT) and OCT angiographic signals. We first project the ensemble of repeated OCT signals into a feature space that represents the power spectral components of eigenvectors through a well-known eigen-decomposition method ...

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    4. Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy

      Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy

      Background There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA’s imaging capabilities. Methods Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns. OCT signal strengths at the superficial retina, deep retina, Sattler’s layer and ...

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    5. OCT‐based angiography of human dermal microvascular reactions to local stimuli: Implications for increasing capillary blood collection volumes

      OCT‐based angiography of human dermal microvascular reactions to local stimuli: Implications for increasing capillary blood collection volumes

      Objectives To measure and compare microvascular responses within the skin of the upper arm to local stimuli, such as heating or rubbing, through the use of optical coherence tomography angiography (OCTA), and to investigate its impact on blood volume collection. Materials and Methods With the use of heat packs or rubbing, local stimulation was applied to the skin of either the left or right upper arm. Data from the stimulated sites were obtained using OCTA comparing pre‐ and post‐stimulation microvascular parameters, such as vessel density, mean vessel diameter, and mean avascular pore size. Additionally, blood was collected using a ...

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    6. Optical coherence tomography angiography monitors human cutaneous wound healing over time

      Optical coherence tomography angiography monitors human cutaneous wound healing over time

      Background: In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high resolution imaging of cutaneous wound healing. Methods: We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such ...

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    7. Optical coherence tomography angiography and cutaneous wound healing

      Optical coherence tomography angiography and cutaneous wound healing

      Background: Examination of the skin’s vascular and structural features is essential in clinical, medical, and research dermatology. However, there is a lack of comprehensive imaging tools that clearly and accurately evaluates the skin’s vascular and structural features. Current techniques are invasive and have inherent preparatory drawbacks. Aim: To use optical coherence tomography angiography (OCTA) for a more accurate depiction of vessels in the skin without the use of a dye or other invasive techniques to visualize and asses the role of the skin’s vasculature during the process’ of wound healing. Method: We used an in-house-built, swept source-OCT ...

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    8. Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions

      Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions

      Background In clinical dermatology, the identification of subsurface vascular and structural features known to be associated with numerous cutaneous pathologies remains challenging without the use of invasive diagnostic tools. Objective To present an advanced optical coherence tomography angiography (OCTA) method to directly visualize capillary-level vascular and structural features within skin in vivo . Methods An advanced OCTA system with a 1310 nm wavelength was used to image the microvascular and structural features of various skin conditions. Subjects were enrolled and OCTA imaging was performed with a field of view of approximately 10 × 10 mm. Skin blood flow was identified using an ...

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    9. Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration

      Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration

      When using optical coherence tomography angiography (OCTA), the development of artifacts due to involuntary movements can severely compromise the visualization and subsequent quantitation of tissue microvasculatures. To correct such an occurrence, we propose a motion compensation method to eliminate artifacts from human skin OCTA by means of step-by-step rigid affine registration, rigid subpixel registration, and nonrigid B-spline registration. To accommodate this remedial process, OCTA is conducted using two matching all-depth volume scans. Affine transformation is first performed on the large vessels of the deep reticular dermis, and then the resulting affine parameters are applied to all-depth vasculatures with a further ...

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    1-9 of 9
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  2. Topics in the News

    1. (9 articles) University of Washington
    2. (9 articles) Ruikang K. Wang
    3. (1 articles) K. U. Leuven
    4. (1 articles) Mount Sinai School of Medicine
    5. (1 articles) University of Toronto
    6. (1 articles) National University of Ireland, Galway
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    Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions Optical coherence tomography angiography and cutaneous wound healing Optical coherence tomography angiography monitors human cutaneous wound healing over time OCT‐based angiography of human dermal microvascular reactions to local stimuli: Implications for increasing capillary blood collection volumes Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy Mapping and Quantitating Penetrating Vessels in Cortical Brain Using Eigen-Decomposition of OCT Signals and Subsequent Principal Component Analysis Microvascular imaging of the skin Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis) Calibration-free time-stretch optical coherence tomography with large imaging depth Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?