1. Articles from Demetrius K. Lopes

    1-4 of 4
    1. Optical coherence tomography: Translation from 3D-printed vascular models of the anterior cerebral circulation to the first human images of implanted surface modified flow diverters

      Optical coherence tomography: Translation from 3D-printed vascular models of the anterior cerebral circulation to the first human images of implanted surface modified flow diverters

      Background The new generation of flow diverters includes a surface modification with a synthetic biocompatible polymer, which makes the device more biocompatible and less thrombogenic. Optical coherence tomography (OCT) can be used to visualize perforators, stent wall apposition, and intra-stent thrombus. Unfortunately real world application of this technology has been limited because of the limited navigability of these devices in the intracranial vessels. In this report, we share our experience of using 3D-printed neurovascular anatomy models to simulate and test the navigability of a commercially available OCT system and to show the application of this device in a patient treated ...

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    2. First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

      First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

      A 64-year-old female presented with an incidentally-discovered right posterior inferior cerebral artery (PICA) aneurysm, initially treated in 2015 by simple coiling. Follow-up demonstrated significant coil compaction that required retreatment. Retreatment was done uneventfully using a Pipeline embolization device (PED) shield deployed starting from the basilar artery and ending at the V4 segment of the vertebral artery. Eight-weeks post-deployment, a follow-up digital subtraction imaging (DSA) and intravascular imaging with optical coherence tomography were obtained. The intravascular imaging demonstrated that the flow diverter had good wall apposition and concentric neointimal growth over the braid with exception to the areas that the PED ...

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      Mentions: St. Jude Medical
    3. Analysis of neointima development in flow diverters using optical coherence tomography imaging

      Analysis of neointima development in flow diverters using optical coherence tomography imaging

      Background Flow diverters are used for the treatment of intracranial aneurysms. Surface modification may decrease the thrombogenicity of flow diverters but the details are unknown. Optical coherence tomography (OCT) is an intravascular imaging test with high resolution which identifies neointimal growth over stents. We compared the development of neointima in a flow diverter and stents with and without surface modification in a swine model. Methods In this study we implanted four devices (two in each carotid artery) in four pigs. The devices used were the Pipeline Flex embolization device (PED Flex, n=6), PED with Shield technology (PED Shield, n ...

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    1-4 of 4
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  2. Topics in the News

    1. (2 articles) Massachusetts General Hospital
    2. (2 articles) Harvard University
    3. (2 articles) Guillermo J. Tearney
    4. (1 articles) Yonsei University
    5. (1 articles) Wakayama Medical University
    6. (1 articles) Cleveland Clinic
    7. (1 articles) SUNY at Stony Brook
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    11. (1 articles) Gentuity
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    13. (1 articles) University of São Paulo
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    Analysis of neointima development in flow diverters using optical coherence tomography imaging First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography Optical coherence tomography: Translation from 3D-printed vascular models of the anterior cerebral circulation to the first human images of implanted surface modified flow diverters Intravascular Optical Coherence Tomography for Neurointerventional Surgery Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss Miniaturizing medical imaging, sensing technology On-chip tunable photonic delay line Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry Review of methods and applications of attenuation coefficient measurements with optical coherence tomography