1. Articles from Christopher A. Girkin

    1-14 of 14
    1. Deep Learning Approaches Predict Glaucomatous Visual Field Damage from Optical Coherence Tomography Optic Nerve Head Enface Images and Retinal Nerve Fiber Layer Thickness Maps

      Deep Learning Approaches Predict Glaucomatous Visual Field Damage from Optical Coherence Tomography Optic Nerve Head Enface Images and Retinal Nerve Fiber Layer Thickness Maps

      Purpose To develop and evaluate a deep learning system for differentiating between eyes with and without glaucomatous visual field damage (GVFD) and predicting the severity of GFVD from spectral domain optical coherence tomography (SDOCT) optic nerve head images. Design Evaluation of a diagnostic technology Participants 9,765 visual field (VF)–SDOCT pairs collected from 1,194 participants with and without GVFD (1909 eyes). Methods Deep learning models were trained to use SDOCT retinal nerve fiber layer (RNFL) thickness maps, RNFL enface images, and confocal scanning laser ophthalmoscopy (CSLO) images to identify eyes with GVFD and predict quantitative VF mean deviation ...

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    2. OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruch’s membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural ...

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    3. Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

      Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

      Purpose : To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods : A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour ...

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    4. Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography

      Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography

      Purpose To evaluate the relationship between intraocular pressure (IOP) and rates of retinal nerve fiber layer (RNFL) thickness change over time measured by spectral-domain (SD) optical coherence tomography (OCT). Design Observational cohort study. Participants The study involved 547 eyes of 339 patients followed up for an average of 3.9±0.9 years. Three hundred eight (56.3%) had a diagnosis of glaucoma and 239 (43.7%) were considered glaucoma suspects. Methods All eyes underwent imaging using the Spectralis SD OCT (Heidelberg Engineering GmbH, Heidelberg, Germany), along with IOP measurements and standard automated perimetry (SAP). Glaucoma progression was defined as ...

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    5. Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes

      Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes

      Purpose To evaluate and compare the diagnostic accuracy of global and sector analyses for detection of early visual field (VF) damage using the retinal nerve fiber layer (RNFL) reference databases of the Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD OCT) devices. Methods Healthy subjects and glaucoma suspects from the Diagnostic Innovations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES) with at least 2 years of follow-up were included. Global and sectoral RNFL measures were classified as within normal limits, borderline (BL), and outside normal limits (ONL ...

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    6. A dual-modal retinal imaging system with adaptive optics

      A dual-modal retinal imaging system with adaptive optics

      An adaptive optics scanning laser ophthalmoscope (AO-SLO) is adapted to provide optical coherence tomography (OCT) imaging. The AO-SLO function is unchanged. The system uses the same light source, scanning optics, and adaptive optics in both imaging modes. The result is a dual-modal system that can acquire retinal images in both en face and cross-section planes at the single cell level. A new spectral shaping method is developed to reduce the large sidelobes in the coherence profile of the OCT imaging when a non-ideal source is used with a minimal introduction of noise. The technique uses a combination of two existing ...

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    7. Effect of Race, Age, and Axial Length on Optic Nerve Head Parameters and Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD-OCT [Clinical Sciences]

      Effect of Race, Age, and Axial Length on Optic Nerve Head Parameters and Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD-OCT [Clinical Sciences]

      Objective To determine the effect of race, demographic, and ocular variables on optic nerve head and retinal nerve fiber layer (RNFL) thickness measurements using spectral-domain optical coherence tomography. Methods In a cross-sectional observational study, 284 normal subjects aged 18 to 84 years were evaluated at 7 sites using Cirrus HD-OCT. Disc area, rim area, average cup-disc ratio, vertical cup-disc ratio, cup volume, and average, temporal, superior, nasal, and inferior RNFL thicknesses were calculated. The main outcome measures were associations between Cirrus HD-OCT optic nerve head and RNFL measurements and age, sex, and race. Results The 284 subjects self-identified as being ...

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    8. Imaging Lamina Cribrosa with Spectral Domain Ocular Coherence Tomography: An overview

      Imaging Lamina Cribrosa with Spectral Domain Ocular Coherence Tomography: An overview

      Glaucoma is characterized by optic nerve head cupping and visual field defects that could be detected with long-term rigorous monitoring of patients. There is not yet a good screening test for the disease, hence emphasis should be on prevention of progression of the disease by risk reduction. Currently, the only proven method to prevent the progressionglaucomatous disease is lowering the intraocular pressure (IOP). The precise mechanism by which IOP contributes to the development and progression of glaucoma is not completely understood [1,2]. This is, in part, due to the variability in individual susceptibility to IOP [3]. To better understand ...

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    9. Profile and Predictors of Normal Ganglion Cell–Inner Plexiform Layer Thickness Measured with Frequency-Domain Optical Coherence Tomography

      Profile and Predictors of Normal Ganglion Cell–Inner Plexiform Layer Thickness Measured with Frequency-Domain Optical Coherence Tomography
      Purpose. To describe the profile and identify the predictors of the ganglion cell–inner plexiform layer (GCIPL) thickness measured with frequency-domain optical coherence tomography (FD-OCT) in normal eyes. Methods. Two hundred eighty-two normal subjects underwent macular and optic disc scanning in both eyes with Cirrus high-definition (HD)-OCT (Carl Zeiss Meditec, Dublin, CA). Linear regression analyses were performed to determine the association between GCIPL thickness and age, sex, ethnicity (Europeans, Africans, Hispanics, Asians, and Indians), eye laterality, refraction, intraocular pressure, axial length, central corneal thickness, mean retinal nerve fiber layer (RNFL) thickness, disc and rim areas, cup-to-disc area, vertical and ...
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    10. Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography

      Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography
      Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer, and macular measurements with spectral-domain optical coherence tomography (SD OCT).Design: Cross-sectional observational study.Participants: Three hundred fifty adult subjects without ocular disease.Methods: Data from SD OCT imaging of the optic nerve head, peripapillary retinal nerve fiber layer (RNFL), and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula.Main Outcome Measures: Optic nerve, RNFL, and ...
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    11. Profile and Predictors of Normal Ganglion Cell-Inner Plexiform Layer Thickness Measured with Frequency Domain Optical Coherence Tomography

      Profile and Predictors of Normal Ganglion Cell-Inner Plexiform Layer Thickness Measured with Frequency Domain Optical Coherence Tomography
      Purpose. To describe the profile and identify the predictors of the ganglion cell-inner plexiform layer (GCIPL) thickness measured with frequency-domain optical coherence tomography (FD-OCT) in normal eyes. Methods. Two hundred and eighty-two normal subjects underwent macular and optic disc scanning in both eyes using Cirrus HD-OCT. Linear regression analyses were performed to determine the association between GCIPL thickness and age, gender, ethnicity (Europeans, Africans, Hispanics, Asians, and Indians), eye laterality, refraction, intraocular pressure, axial length, central corneal thickness, mean retinal nerve fiber layer (RNFL) thickness, disc and rim areas, cup-to-disc area, vertical and horizontal cup-to-disc diameter ratios, vertical rim thickness ...
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    12. The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral domain optical coherence tomography.

      The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral domain optical coherence tomography.
      Purpose: To evaluate the effect of race (African or European descent), age, disc area, and severity of disease on the diagnostic ability of spectral domain optical coherence tomography (SDOCT) imaging of the optic nerve, macula, and retinal nerve fiber layer (RNFL) in the detection of glaucomatous injury. Design: Cross-sectional observational study. Methods: Data from SDOCT images from 312 eyes from 167 subjects without ocular disease and 233 eyes from 163 patients with open angle glaucoma. Receiver operating characteristic (ROC) regression modeling technique was used to evaluate the influence of race on the diagnostic accuracies of the ONH, RNFL and macular ...
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    13. Association between retinal thickness measured by spectral-domain optical coherence tomography (OCT) and rod-mediated dark adaptation in non-exudative age-related maculopathy

      Association between retinal thickness measured by spectral-domain optical coherence tomography (OCT) and rod-mediated dark adaptation in non-exudative age-related maculopathy
      Aim To examine associations between retinal thickness and rod-mediated dark adaptation in older adults with non-exudative age-related maculopathy (ARM) or normal macular health. Methods A cross-sectional study was conducted with 74 adults ≥50 years old from the comprehensive ophthalmology and retina services of an academic eye centre. ARM presence and disease severity in the enrolment eye was defined by the masked grading of stereofundus photos using the Clinical Age-Related Maculopathy grading system. High-definition, spectral-domain optical coherence tomography was used to estimate retinal thickness in a grid of regions in the macula. Rod-mediated dark adaptation, recovery of light sensitivity after a ...
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    14. Optical coherence tomography of the retina and optic nerve – a review

      Optical coherence tomography (OCT) is a rapid non-contact method that allows in vivo imaging of the retina, optic nerve head and retinal nerve fibre layer (RNFL). Since its introduction in Ophthalmology approximately a decade ago, the use of this technology has disseminated into the clinical practice. OCT has proven to be a useful ancillary tool for assessing retinal diseases because of its capability to provide cross-sectional images of the retina, and also to perform quantitative analysis of retinal morphology. In glaucoma, the OCT represents one of the methods capable of documenting and analysing optic disc and RNFL morphology in attempt ...
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    1-14 of 14
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    1. (14 articles) Christopher A. Girkin
    2. (12 articles) University of Alabama
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    Association between retinal thickness measured by spectral-domain optical coherence tomography (OCT) and rod-mediated dark adaptation in non-exudative age-related maculopathy The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral domain optical coherence tomography. Profile and Predictors of Normal Ganglion Cell-Inner Plexiform Layer Thickness Measured with Frequency Domain Optical Coherence Tomography Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography Profile and Predictors of Normal Ganglion Cell–Inner Plexiform Layer Thickness Measured with Frequency-Domain Optical Coherence Tomography Imaging Lamina Cribrosa with Spectral Domain Ocular Coherence Tomography: An overview Effect of Race, Age, and Axial Length on Optic Nerve Head Parameters and Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD-OCT [Clinical Sciences] A dual-modal retinal imaging system with adaptive optics Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography Intravitreal Ranibizumab Monotherapy or Combined with Laser for Diabetic Macular Edema (OCT guided study) Prospective evaluation of drug eluting self‐apposing stent for the treatment of unprotected left main coronary artery disease: 1‐year results of the TRUNC study Clinical validation of the RTVue optical coherence tomography angiography image quality indicators