1. Articles from Alexander Lam

    1-3 of 3
    1. Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study

      Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study

      Aims To evaluate the distributions of quantitative optical coherence tomography angiography (OCT-A) metrics and its associated factors in children. Methods 1059 children aged 6–8 years were recruited from the Hong Kong Children Eye Study. All the participants underwent OCT-A with a swept-source OCT. Retinal microvasculature on superficial capillary plexus was assessed and quantified by a customised automated image analysis programme. Univariable and multiple linear regression analyses were performed to determine systemic (body mass index (BMI), waist circumference, head circumference and blood pressure), demographic and ocular (axial length (AL), macular thickness and volume, retinal nerve fibre layer (RNFL) thickness and ...

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    2. Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

      Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

      Aim To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients with diabetes, and to compare the strength of associations between BCVA with ICA and other OCT-A metrics. Methods A cross-sectional study involved 447 eyes from 299 patients with diabetes. All participants underwent OCT-A with a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme was used to quantify ICA (the mean of the 10 largest areas including foveal avascular zone (FAZ) area (ICA10_FAZ) and excluding FAZ area (ICA10_excFAZ)) and other OCT-A metrics (FAZ area ...

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    3. Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes

      Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes

      Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are influenced by ocular, systemic and demographic variables in subjects with diabetes. We conducted an observational cross-sectional study and included 434 eyes from 286 patients with diabetes. Foveal avascular zone (FAZ) area, FAZ circularity, total and parafoveal vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI) from the superficial capillary plexus OCT-angiogram were measured ...

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    1-3 of 3
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    1. (3 articles) The Chinese University of Hong Kong
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    Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population Optical coherence tomography angiography and microvascular changes in diabetic retinopathy: a systematic review High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis Ultra-wide optical coherence tomography angiography in diabetic retinopathy Joint Segmentation and Uncertainty Visualization of Retinal Layers in Optical Coherence Tomography Images using Bayesian Deep Learning Predictive accuracy of partial coherence interferometry and swept-source optical coherence tomography for intraocular lens power calculation Evaluation of Corneal Epithelial Thickness Imaged by the High Definition Optical Coherence Tomography in Healthy Eyes Relationship between filtering bleb vascularization and surgical outcomes after trabeculectomy: an optical coherence tomography angiography study