1. Articles from Jonathan Samuelson

    1-4 of 4
    1. The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors

      The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors

      Histopathologic surgical margin assessment in veterinary patients is an imprecise science with assessment limited to a small proportion of the surgical margin due to time and finances. Incomplete excision of canine mast cell tumors (MCTs) alters treatment recommendations and prognosis. Optical coherence tomography (OCT) is a novel imaging modality that has been reported in a single veterinary study for surgical margin assessment. Twenty‐five dogs with 34 MCTs were enrolled in a prospective pilot‐study to assess the imaging characteristics of canine MCTs with OCT and to evaluate the feasibility and utility of OCT‐guided histopathology. All dogs underwent routine ...

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    2. Comparison between optical coherence tomographic and histopathologic appearances of artifacts caused by common surgical conditions and instrumentation

      Comparison between optical coherence tomographic and histopathologic appearances of artifacts caused by common surgical conditions and instrumentation

      Objective To document the appearance of artifacts created by commonly encountered surgical conditions and instrumentation on optical coherence tomography (OCT) and to compare these findings with histopathology. Study design Ex vivo study. Animals Five canine cadavers. Methods Skin, subcutaneous fat, skeletal muscle, and fascia samples were obtained from fresh canine cadavers. Blood pooling, hemostatic crushing, scalpel blade cut, monopolar electrosurgery, bipolar vessel sealing device, and ultrasonic energy surgical artifacts were induced on each tissue type. Each specimen was imaged with OCT and subsequently histologically processed. Results Most surgical instrumentation used for tumor excision created a high‐scattering region with local ...

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    3. Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography

      Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography

      Optical coherence tomography (OCT) is a rapid non‐invasive imaging technique that has shown high sensitivity for intraoperative surgical margin assessment in human breast cancer clinical trials. This promising technology has not been evaluated in veterinary medicine. The objective of this study was to correlate normal and abnormal histological features with OCT images for surgical margins from excised canine soft tissue sarcoma (STS) and to establish image evaluation criteria for identifying positive surgical margins. Fourteen client‐owned dogs underwent surgical resection of a STS and OCT imaging of 2‐4 areas of interest on the resected specimen were performed. Following ...

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    4. Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Background and Objective Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from muscle and adipose tissue. Study Design and Methods In this study, tumor margin delineation in 19 feline and canine veterinary patients was achieved with intraoperative OCT to help validate tumor ...

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    1-4 of 4
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    1. (4 articles) University of Illinois at Urbana-Champaign
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    Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography Comparison between optical coherence tomographic and histopathologic appearances of artifacts caused by common surgical conditions and instrumentation The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors Editorial – Optical Coherence Tomography Angiography: Considerations Regarding Diagnostic Parameters Imaging of the optic nerve: technological advances and future prospects Optical coherence tomography assessment of pulmonary vascular remodeling in advanced heart failure. The OCTOPUS-CHF study Systems and methods for automated widefield optical coherence tomography angiography OCT signal processing device and recording medium Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis Detection of pachychoroid neovasculopathy with optical coherence tomography angiography versus dye angiography imaging Optical Coherence Tomography-Based Choroidal Structural Analysis and Vascularity Index in Best Vitelliform Macular Dystrophy