1. Articles from Pin-Chieh Huang

    1-5 of 5
    1. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...

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    2. Local wavefront mapping in tissue using computational adaptive optics OCT

      Local wavefront mapping in tissue using computational adaptive optics OCT

      The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction ...

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    3. Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

      Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

      While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.

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    4. Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Objective: A novel hearing-aid scheme using magnetomotive nanoparticles (MNPs) as transducers in the tympanic membrane (TM) is proposed, aiming to noninvasively and directly induce a modulated vibration on the TM. Methods: In this feasibility study, iron-oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles were applied on ex vivo rat TM tissues and allowed to diffuse over ~2 hr. Subsequently, magnetic force was exerted on the MNP-laden TM via a programmable electromagnetic solenoid to induce the magnetomotion. Optical coherence tomography (OCT), along with its phase-sensitive measurement capabilities, was utilized to visualize and quantify the nanometer-scale vibrations generated on the ...

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    5. Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Influenced by both the intrinsic viscoelasticity of the tissue constituents and the time-evolved redistribution of fluid within the tissue, the biomechanical response of skin can reflect not only localized pathology but also systemic physiology of an individual. While clinical diagnosis of skin pathologies typically relies on visual inspection and manual palpation, a more objective and quantitative approach for tissue characterization is highly desirable. Optical coherence tomography (OCT) is an interferometry-based imaging modality that enables in vivo assessment of cross-sectional tissue morphology with micron-scale resolution, which surpasses those of most standard clinical imaging tools, such as ultrasound imaging and magnetic resonance ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) University of Illinois at Urbana-Champaign
    2. (5 articles) Stephen A. Boppart
    3. (3 articles) Eric J. Chaney
    4. (2 articles) Ryan L. Shelton
    5. (1 articles) Fredrick A. South
    6. (1 articles) Paritosh Pande
    7. (1 articles) Guillermo L. Monroy
    8. (1 articles) Northwestern University
    9. (1 articles) Wenzhou Medical College
    10. (1 articles) Jay S. Duker
    11. (1 articles) Joel S. Schuman
    12. (1 articles) Jin Wook Jeoung
    13. (1 articles) Hao F. Zhang
    14. (1 articles) James G. Fujimoto
    15. (1 articles) Cheng Sun
    16. (1 articles) Andre J. Witkin
    17. (1 articles) Tomey Corporation
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    Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography Local wavefront mapping in tissue using computational adaptive optics OCT Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study A Deep Learning Approach in Rebubbling After Descemet's Membrane Endothelial Keratoplasty Impact of optical coherence tomography‐derived neointimal tissue morphology on development of very late in‐stent restenosis Handheld volumetric manual compression‐based quantitative micro‐elastography Comparison of the Iowa Reference Algorithm to the Heidelberg Spectralis optical coherence tomography segmentation algorithm Quantitative assessment of the effect of acute anaerobic exercise on macular perfusion via swept-source optical coherence tomography angiography in young football players Axial length measurement and detection rates using a swept-source optical coherence tomography based biometer in the presence of a dense vitreous hemorrhage