Articles from Yuye Ling

1. Multi-scale reconstruction of undersampled spectral-spatial OCT data for coronary imaging using deep learning

   Explore IEEE Xplore May 23 2022 Cardiology

   

   Coronary artery disease (CAD) is a cardiovascular condition with high morbidity and mortality. Intravascular optical coherence tomography (IVOCT) has been considered as an optimal imagining system for the diagnosis and treatment of CAD. Constrained by Nyquist theorem, dense sampling in IVOCT attains high resolving power to delineate cellular structures/features. There is a trade-off between high spatial resolution and fast scanning rate for coronary imaging. In this paper, we propose a viable spectral-spatial acquisition method that down-scales the sampling process in both spectral and spatial domain while maintaining high quality in image reconstruction. The down-scaling schedule boosts data acquisition speed ...

   Read Full Article

   Comment

   Mentions: Mount Sinai School of Medicine University of Alabama

2. Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

   Explore OSA | OSA Publishing Apr 7 2021 Ophthalmology

   

   An accurate and automated tissue segmentation algorithm for retinal optical coherence tomography (OCT) images is crucial for the diagnosis of glaucoma. However, due to the presence of the optic disc, the anatomical structure of the peripapillary region of the retina is complicated and is challenging for segmentation. To address this issue, we develop a novel graph convolutional network (GCN)-assisted two-stage framework to simultaneously label the nine retinal layers and the optic disc. Specifically, a multi-scale global reasoning module is inserted between the encoder and decoder of a U-shape neural network to exploit anatomical prior knowledge and perform spatial reasoning ...

   Read Full Article

   Comment

   Mentions: Shanghai Jiao Tong University

3. Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation

   Explore IEEE Xplore Feb 18 2021 NDE/NDT

   

   Saturation artifacts in optical coherence tomography (OCT) occur when received signal exceeds the dynamic range of spectrometer. Saturation artifact shows a streaking pattern and could impact the quality of OCT images, leading to inaccurate medical diagnosis. In this paper, we automatically localize saturation artifacts and propose an artifact correction method via inpainting. We adopt a dictionary-based sparse representation scheme for inpainting. Experimental results demonstrate that, in both case of synthetic artifacts and real artifacts, our method outperforms interpolation method and Euler's elastica method in both qualitative and quantitative results. The generic dictionary offers similar image quality when applied to ...

   Read Full Article

   Comment

   Mentions: University of Alabama Shanghai Jiao Tong University

4. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

   Explore OSA | OSA Publishing Nov 24 2020

   

   We report on the investigation of spectral leakage’s impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches the theoretical resolution limit.

   Read Full Article

   Comment

   Mentions: University of Alabama Medical University of Vienna Singapore Eye Research Institute

5. Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

   Explore arxiv.org Jan 14 2020

   

   Optical coherence tomography (OCT) is a volumetric imaging modality that empowers the clinicians and scientists to noninvasively visualize and examine the microscopic cross-sectional architectures of biological samples. By taking advantages of the coherence gating, OCT could achieve micrometer-level axial sectioning with high sensitivity. In the past decade, substantial efforts have been made to push the axial resolution of Fourier-domain OCT (FD-OCT) further into the sub-micron regime via physically extending the system’s spectral bandwidth. Here, we would like to offer a new perspective on this problem. We argue that the coupling between the axial resolution and the spectral bandwidth in ...

   Read Full Article

   Comment

   Mentions: University of Alabama Singapore Eye Research Institute Nanyang Technological University

6. High-sensitive swept-source optical coherence tomography system and methods of use thereof

   Explore uspto.gov Oct 1 2019 Patents

   

   An exemplary system can be provided which can include, for example, a plurality of source arrangements configured to provide a plurality of electro-magnetic radiations to at least one of at least one sample or at least one reference structure, a first arrangement configured to receive a first radiation(s) from the reference structure(s), a second arrangement configured to receive a second radiation(s) from the sample(s), where a portion(s) of the second radiation(s) can be in an invisible spectrum, a third arrangement configured to combine the first radiation(s) and the second radiation(s) into a ...

   Read Full Article

   Comment

   Mentions: Columbia University Christine P. Hendon

7. Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph

   Explore OSA | OSA Publishing Jan 28 2019

   

   Here we present a novel phase-sensitive swept-source optical coherence tomography (PhS-SS-OCT) system. The simultaneously recorded calibration signal, which is commonly used in SS-OCT to stabilize the phase, is randomly sub-sampled during the acquisition, and it is later reconstructed based on the Compressed Sensing (CS) theory. We first mathematically investigated the method, and verified it through computer simulations. We then conducted a vibrational frequency test and a flow velocity measurement in phantoms to demonstrate the system’s capability of handling phase-sensitive tasks. The proposed scheme shows excellent phase stability with greatly discounted data bandwidth compared with conventional procedures. We further showcased ...

   Read Full Article

   Comment

   Mentions: Imperial College London Columbia University Christine P. Hendon

8. High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)

   Explore Academic Commons Dec 18 2017 Student Theses

   

   In the past decades, the performance of swept source optical coherence tomography (SS-OCT) has experienced an unprecedented improvement which is mainly driven by the rapidly evolving laser technologies: the state-of-art SS-OCT is now tens of dB more sensitive, six orders of magnitude faster, and seeing ten times deeper than the original version of time domain OCT. Regardless of the abovementioned progress, the phase instability is always considered the biggest weakness of SS-OCT and the mainstream belief often states that the mechanical tuning mechanism of the swept source is to blame. In my study, I first developed a high-speed phase-stable SS-OCT ...

   Read Full Article

   Comment

   Mentions: Columbia University Christine P. Hendon

9. Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

   Explore Wiley Online Library Nov 22 2017

   

   A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multi-contrast imaging of human myocardium in one-shot measurement. The intensity contrast and functional contrasts, including the ratio between the cross- and co- polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate micro-structures in the myocardium and differentiate the fibrotic myocardium from normal or ablated myocardium based the functional contrasts provided by the CP-OCT system. The feasibility of using A-line profiles from the two orthogonal polarization ...

   Read Full Article

   Comment

   Mentions: Columbia University Christine P. Hendon

10. Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging

    Explore OSA | OSA Publishing Oct 10 2017

    

    Sparse representation theory is an exciting area of research with recent applications in medical imaging and detection, segmentation, and quantitative analysis of biological processes. We present a variant on the robust-principal component analysis (RPCA) algorithm, called frequency constrained RPCA (FC-RPCA), for selectively segmenting dynamic phenomena that exhibit spectra within a user-defined range of frequencies. The algorithm lacks subjective parameter tuning and demonstrates robust segmentation in datasets containing multiple motion sources and high amplitude noise. When tested on 17 ex-vivo , time lapse optical coherence tomography (OCT) B-scans of human ciliated epithelium, segmentation accuracies ranged between 91–99% and consistently out-performed traditional ...

    Read Full Article

    Comment

    Mentions: Columbia University Christine P. Hendon

11. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

    Explore OSA | OSA Publishing Aug 1 2017 Tunable Sources

    

    The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system’s performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications. Biological experiments were demonstrated within ex vivo human tracheobronchial ciliated epithelium where both the ciliary motion and ...

    Read Full Article

    Comment

    Mentions: Columbia University Christine P. Hendon

12. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

    Explore OSA | OSA Publishing Jul 18 2017 Tunable Sources

    

    The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system’s performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications. Biological experiments were demonstrated within ex vivo human tracheobronchial ciliated epithelium where both the ciliary motion and ...

    Read Full Article

    Comment

    Mentions: Columbia University Christine P. Hendon

13. Phase-noise analysis of swept-source optical coherence tomography systems

    Explore OSA | OSA Publishing Mar 23 2017 Tunable Sources

    

    We propose a new model to characterize the phase noise in swept-source optical coherence tomography (SS-OCT). The new model explicitly incorporates scanning variability, timing jitter, and sample location in addition to intensity noise (shot noise). The model was analyzed and validated by using both Monte Carlo methods and experiments. We suggest that the proposed model can be used as a guideline for future SS-OCT experimental designs.

    Read Full Article

    Comment

    Mentions: Columbia University Christine P. Hendon

14. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

    Explore Wiley Online Library Feb 23 2017

    

    Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly imaged by two OCT systems: one system centered at 1,300 nm with 6.5 μm axial resolution and 15 μm lateral resolution, and the other centered at 800 nm ...

    Read Full Article

    Comment

    Mentions: Columbia University Yale University Christine P. Hendon

Topics in the News

1. (9 articles) Columbia University
2. (9 articles) Christine P. Hendon
3. (4 articles) Shanghai Jiao Tong University
4. (4 articles) University of Alabama
5. (2 articles) Singapore Eye Research Institute
6. (2 articles) Nanyang Technological University
7. (1 articles) Medical University of Vienna
8. (1 articles) Imperial College London
9. (1 articles) Yale University
10. (1 articles) Mount Sinai School of Medicine
11. (1 articles) University of Bologna
12. (1 articles) University of Cambridge
13. (1 articles) FDA
14. (1 articles) Notal Vision
15. (1 articles) Topcon Medical Systems
16. (1 articles) Tomey Corporation

Popular Articles

• Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector  
• Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography  
• Beyond Fourier transform: break the axial resolution limit in optical coherence tomography  
• Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images  
• Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging  
• Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph  
• Phase-noise analysis of swept-source optical coherence tomography systems  
• High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)  
• Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography  
• Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector  

Picture Gallery