1. Articles from Yuye Ling

    1-14 of 14
    1. Multi-scale reconstruction of undersampled spectral-spatial OCT data for coronary imaging using deep learning

      Multi-scale reconstruction of undersampled spectral-spatial OCT data for coronary imaging using deep learning

      Coronary artery disease (CAD) is a cardiovascular condition with high morbidity and mortality. Intravascular optical coherence tomography (IVOCT) has been considered as an optimal imagining system for the diagnosis and treatment of CAD. Constrained by Nyquist theorem, dense sampling in IVOCT attains high resolving power to delineate cellular structures/features. There is a trade-off between high spatial resolution and fast scanning rate for coronary imaging. In this paper, we propose a viable spectral-spatial acquisition method that down-scales the sampling process in both spectral and spatial domain while maintaining high quality in image reconstruction. The down-scaling schedule boosts data acquisition speed ...

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    2. Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

      Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images

      An accurate and automated tissue segmentation algorithm for retinal optical coherence tomography (OCT) images is crucial for the diagnosis of glaucoma. However, due to the presence of the optic disc, the anatomical structure of the peripapillary region of the retina is complicated and is challenging for segmentation. To address this issue, we develop a novel graph convolutional network (GCN)-assisted two-stage framework to simultaneously label the nine retinal layers and the optic disc. Specifically, a multi-scale global reasoning module is inserted between the encoder and decoder of a U-shape neural network to exploit anatomical prior knowledge and perform spatial reasoning ...

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    3. Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation

      Inpainting for Saturation Artifacts in Optical Coherence Tomography using Dictionary-based Sparse Representation

      Saturation artifacts in optical coherence tomography (OCT) occur when received signal exceeds the dynamic range of spectrometer. Saturation artifact shows a streaking pattern and could impact the quality of OCT images, leading to inaccurate medical diagnosis. In this paper, we automatically localize saturation artifacts and propose an artifact correction method via inpainting. We adopt a dictionary-based sparse representation scheme for inpainting. Experimental results demonstrate that, in both case of synthetic artifacts and real artifacts, our method outperforms interpolation method and Euler's elastica method in both qualitative and quantitative results. The generic dictionary offers similar image quality when applied to ...

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    4. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      We report on the investigation of spectral leakage’s impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches the theoretical resolution limit.

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    5. Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

      Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

      Optical coherence tomography (OCT) is a volumetric imaging modality that empowers the clinicians and scientists to noninvasively visualize and examine the microscopic cross-sectional architectures of biological samples. By taking advantages of the coherence gating, OCT could achieve micrometer-level axial sectioning with high sensitivity. In the past decade, substantial efforts have been made to push the axial resolution of Fourier-domain OCT (FD-OCT) further into the sub-micron regime via physically extending the system’s spectral bandwidth. Here, we would like to offer a new perspective on this problem. We argue that the coupling between the axial resolution and the spectral bandwidth in ...

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    6. High-sensitive swept-source optical coherence tomography system and methods of use thereof

      High-sensitive swept-source optical coherence tomography system and methods of use thereof

      An exemplary system can be provided which can include, for example, a plurality of source arrangements configured to provide a plurality of electro-magnetic radiations to at least one of at least one sample or at least one reference structure, a first arrangement configured to receive a first radiation(s) from the reference structure(s), a second arrangement configured to receive a second radiation(s) from the sample(s), where a portion(s) of the second radiation(s) can be in an invisible spectrum, a third arrangement configured to combine the first radiation(s) and the second radiation(s) into a ...

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    7. Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph

      Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph

      Here we present a novel phase-sensitive swept-source optical coherence tomography (PhS-SS-OCT) system. The simultaneously recorded calibration signal, which is commonly used in SS-OCT to stabilize the phase, is randomly sub-sampled during the acquisition, and it is later reconstructed based on the Compressed Sensing (CS) theory. We first mathematically investigated the method, and verified it through computer simulations. We then conducted a vibrational frequency test and a flow velocity measurement in phantoms to demonstrate the system’s capability of handling phase-sensitive tasks. The proposed scheme shows excellent phase stability with greatly discounted data bandwidth compared with conventional procedures. We further showcased ...

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    8. High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)

      High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)

      In the past decades, the performance of swept source optical coherence tomography (SS-OCT) has experienced an unprecedented improvement which is mainly driven by the rapidly evolving laser technologies: the state-of-art SS-OCT is now tens of dB more sensitive, six orders of magnitude faster, and seeing ten times deeper than the original version of time domain OCT. Regardless of the abovementioned progress, the phase instability is always considered the biggest weakness of SS-OCT and the mainstream belief often states that the mechanical tuning mechanism of the swept source is to blame. In my study, I first developed a high-speed phase-stable SS-OCT ...

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    9. Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multi-contrast imaging of human myocardium in one-shot measurement. The intensity contrast and functional contrasts, including the ratio between the cross- and co- polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate micro-structures in the myocardium and differentiate the fibrotic myocardium from normal or ablated myocardium based the functional contrasts provided by the CP-OCT system. The feasibility of using A-line profiles from the two orthogonal polarization ...

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    10. Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging

      Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging

      Sparse representation theory is an exciting area of research with recent applications in medical imaging and detection, segmentation, and quantitative analysis of biological processes. We present a variant on the robust-principal component analysis (RPCA) algorithm, called frequency constrained RPCA (FC-RPCA), for selectively segmenting dynamic phenomena that exhibit spectra within a user-defined range of frequencies. The algorithm lacks subjective parameter tuning and demonstrates robust segmentation in datasets containing multiple motion sources and high amplitude noise. When tested on 17 ex-vivo , time lapse optical coherence tomography (OCT) B-scans of human ciliated epithelium, segmentation accuracies ranged between 91–99% and consistently out-performed traditional ...

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    11. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system’s performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications. Biological experiments were demonstrated within ex vivo human tracheobronchial ciliated epithelium where both the ciliary motion and ...

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    12. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system’s performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications. Biological experiments were demonstrated within ex vivo human tracheobronchial ciliated epithelium where both the ciliary motion and ...

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    13. Phase-noise analysis of swept-source optical coherence tomography systems

      Phase-noise analysis of swept-source optical coherence tomography systems

      We propose a new model to characterize the phase noise in swept-source optical coherence tomography (SS-OCT). The new model explicitly incorporates scanning variability, timing jitter, and sample location in addition to intensity noise (shot noise). The model was analyzed and validated by using both Monte Carlo methods and experiments. We suggest that the proposed model can be used as a guideline for future SS-OCT experimental designs.

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    14. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly imaged by two OCT systems: one system centered at 1,300 nm with 6.5 μm axial resolution and 15 μm lateral resolution, and the other centered at 800 nm ...

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    1-14 of 14
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  2. Topics in the News

    1. (9 articles) Columbia University
    2. (9 articles) Christine P. Hendon
    3. (4 articles) Shanghai Jiao Tong University
    4. (4 articles) University of Alabama
    5. (2 articles) Singapore Eye Research Institute
    6. (2 articles) Nanyang Technological University
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    Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography Phase-noise analysis of swept-source optical coherence tomography systems Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis) Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph Beyond Fourier transform: break the axial resolution limit in optical coherence tomography Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work