1. Articles from Darius Mehregan

    1-11 of 11
    1. Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      The current gold standard for the clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients which can add an additional burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT), with its high-resolution and intermediate penetration depth, can potentially provide required diagnostic information noninvasively. Here we present an image analysis algorithm, 'optical properties extraction (OPE)', that improves the specificity and sensitivity of OCT by identifying unique ...

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    2. The use of optical coherence tomography to analyze the efficacy of skin care products

      The use of optical coherence tomography to analyze the efficacy of skin care products

      In this study, we assess the applicability of optical coherence tomography (OCT) for non-invasive imaging of skin morphology for the assessment of efficacy of cosmetic skin wrinkle-reduction products in humans. Evaluation of skin care products for reduction of facial wrinkles is largely limited to photographic (non-quantitative) comparison of skin surface texture before and after either single or prolonged application of skin care product. OCT could be a technique for monitoring changes in cross-sectional skin morphology. An optical attenuation coefficient analysis is also carried out to quantitatively study the changes in different layers of the skin.

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    3. Swept-Source Optical Coherence Tomography–Supervised Biopsy

      Swept-Source Optical Coherence Tomography–Supervised Biopsy

      BACKGROUND Currently, only skin biopsy can provide definitive histological confirmation for the diagnosis of skin diseases. To improve the diagnostic accuracy and to assist the dermatologist, various imaging techniques have been added to the examination of skin. Among all these techniques, the recent advances in optical coherence tomography (OCT) have made it possible to image the skin up to 2 millimeters in depth. OBJECTIVE To testify the feasibility of OCT imaging in skin biopsy, the authors investigated the OCT imaging for real-time visualization of needle insertion and punch biopsy techniques in both a tissue phantom and biological tissue. MATERIALS AND ...

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      Mentions: Saba Adabi
    4. Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms

      Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms

      Currently, diagnosis of skin diseases is based primarily on the visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a subjective visual assessment. Tools for automated pattern recognition can provide objective information to support clinical decision-making. Noninvasive skin imaging techniques provide complementary information to the clinician. In recent years, optical coherence tomography (OCT) has become a powerful skin imaging technique. According to specific functional needs, skin architecture varies across different parts of the body, as do the textural characteristics in OCT images. There is ...

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      Mentions: Saba Adabi
    5. An overview of methods to mitigate artifacts in optical coherence tomography imaging of the skin

      An overview of methods to mitigate artifacts in optical coherence tomography imaging of the skin

      Background Optical coherence tomography (OCT) of skin delivers three-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution modality, OCT images suffer from some artifacts that lead to misinterpretation of tissue structures. Therefore, an overview of methods to mitigate artifacts in OCT imaging of the skin is of paramount importance. Speckle, intensity decay, and blurring are three major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT. Intensity decay is a deterioration of light with respect to depth, and blurring is the consequence of deficiencies of optical components ...

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    6. Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms

      Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms

      Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a subjective visual assessment. Tools for automated pattern recognition can provide objective information to support clinical decision-making. Noninvasive skin imaging techniques provide complementary information to the clinician. In recent years, optical coherence tomography has become a powerful skin imaging technique. According to specific functional needs, skin architecture varies across different parts of the body, as do the textural characteristics in OCT images. There is, therefore, a ...

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      Mentions: Saba Adabi
    7. Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin

      Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin

      Identifying the location of the dermal epidermal junction (DEJ) in skin images is essential in several clinical applications of dermatology such as epidermal thickness determination in healthy versus unhealthy skins, such as basal cell carcinoma. Optical coherence tomography (OCT) facilitates the visual detection of DEJ in vivo . However, due to the granular texture of speckle and a low contrast between dermis and epidermis, a skin border detection method is required for DEJ localization. Current DEJ algorithms work well for skins with a visible differentiable epidermal layer but not for the skins of different body sites. In this paper, we present ...

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      Mentions: Saba Adabi
    8. An intelligent despeckling method for swept source optical coherence tomography images of skin

      An intelligent despeckling method for swept source optical coherence tomography images of skin

      Optical Coherence Optical coherence tomography is a powerful high-resolution imaging method with a broad biomedical application. Nonetheless, OCT images suffer from a multiplicative artefacts so-called speckle, a result of coherent imaging of system. Digital filters become ubiquitous means for speckle reduction. Addressing the fact that there still a room for despeckling in OCT, we proposed an intelligent speckle reduction framework based on OCT tissue morphological, textural and optical features that through a trained network selects the winner filter in which adaptively suppress the speckle noise while preserve structural information of OCT signal. These parameters are calculated for different steps of ...

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      Mentions: Saba Adabi
    9. Speckle reduction of OCT images using an adaptive cluster-based filtering

      Speckle reduction of OCT images using an adaptive cluster-based filtering

      Optical coherence tomography (OCT) has become a favorable device in the dermatology discipline due to its moderate resolution and penetration depth. OCT images however contain grainy pattern, called speckle, due to the broadband source that has been used in the configuration of OCT. So far, a variety of filtering techniques is introduced to reduce speckle in OCT images. Most of these methods are generic and can be applied to OCT images of different tissues. In this paper, we present a method for speckle reduction of OCT skin images. Considering the architectural structure of skin layers, it seems that a skin ...

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      Mentions: Saba Adabi
    10. Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Optical Coherence Tomography (OCT) offers real-time high-resolution three-dimensional images of tissue microstructures. In this study, we used OCT skin images acquired from ten volunteers, neither of whom had any skin conditions addressing the features of their anatomic location. OCT segmented images are analyzed based on their optical properties (attenuation coefficient) and textural image features e.g., contrast, correlation, homogeneity, energy, entropy, etc. Utilizing the information and referring to their clinical insight, we aim to make a comprehensive computational model for the healthy skin. The derived parameters represent the OCT microstructural morphology and might provide biological information for generating an atlas ...

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      Mentions: Saba Adabi
    1-11 of 11
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  2. Topics in the News

    1. (8 articles) Saba Adabi
    2. (1 articles) University of Kent
    3. (1 articles) Technical University of Denmark (DTU)
    4. (1 articles) Peter E. Andersen
    5. (1 articles) Adrian G. Podoleanu
    6. (1 articles) Institute of Applied Physics
    7. (1 articles) Medical University of Vienna
    8. (1 articles) Kyungpook National University
    9. (1 articles) Singapore Eye Research Institute
    10. (1 articles) University of Western Australia
    11. (1 articles) Stefan G. Sacu
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    Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues Speckle reduction of OCT images using an adaptive cluster-based filtering An intelligent despeckling method for swept source optical coherence tomography images of skin Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms An overview of methods to mitigate artifacts in optical coherence tomography imaging of the skin Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms Swept-Source Optical Coherence Tomography–Supervised Biopsy The use of optical coherence tomography to analyze the efficacy of skin care products Refractive index correction in optical coherence tomography images of multilayer tissues Full-range space-division multiplexing optical coherence tomography angiography Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)