1. Articles from Lin Huang

    1-3 of 3
    1. Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography

      Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography

      Detecting articular cartilage (AC) degeneration in its early stage plays a critical role in the diagnosis and treatment of osteoarthritis (OA). Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to the alteration and disruption of collagen organization that happens during OA progression. This study proposes an effective OA evaluating method based on PS-OCT imaging. A slope-based analysis is applied on the phase retardation images to segment articular cartilage into three zones along the depth direction. The boundaries and birefringence coefficients (BRCs) of each zone are quantified. Two parameters, namely phase homogeneity index (PHI) and zonal distinguishability ( D z), are further developed ...

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    2. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

      A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method is validated on phantoms composed of layers of different materials. Articular cartilage samples from adult swine are segmented with the method. The characteristics in each segmented zone are also examined ...

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    3. Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Polarization-sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are two imaging modalities with different resolutions, field-of-views (FOV), and contrasts, while they both have the capability of imaging collagen fibers in biological tissues. PS-OCT can measure the tissue birefringence which is induced by highly organized fibers while SHG can image the collagen fiber organization with high resolution. Articular cartilage, with abundant structural collagen fibers, is a suitable sample to study the correlation between PS-OCT and SHG microscopy. Qualitative conjecture has been made that the phase retardation measured by PS-OCT is affected by the relationship between the collagen fiber ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) University of British Columbia
    2. (2 articles) Simon Fraser University
    3. (2 articles) Myeong Jin Ju
    4. (1 articles) South China Normal University
    5. (1 articles) Indiana University
    6. (1 articles) Donald T. Miller
    7. (1 articles) Boston Scientific
    8. (1 articles) Abbot
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    Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography Optical coherence tomography angiography (OCTA) findings in Serpiginous Choroiditis Changes in retinal layer thickness with maturation in the dog: an in vivo spectral domain - optical coherence tomography imaging study Optical coherence tomography angiography analysis of fabry disease An unsupervised hierarchical approach for automatic intra‐retinal cyst segmentation in spectral‐domain optical coherence tomography images Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography Cellular Scale Imaging of Transparent Retinal Structures and Processes Using Adaptive Optics Optical Coherence Tomography Optical Coherence Tomography Imaging in Acute Myocardial Infarction: Calcified Nodule as a Culprit Lesion Study of low-peak-power highly coherent broadband supercontinuum generation through a dispersion-engineered Si-rich silicon nitride waveguide Invasive Coronary Artery Imaging Using Optical Coherence Tomography: A Cost-effectiveness and Implementation Process Analysis (Thesis)