1. Articles from Peter I. Bonta

    1-5 of 5
    1. In vivo multifunctional optical coherence tomography at the periphery of the lungs

      In vivo multifunctional optical coherence tomography at the periphery of the lungs

      Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is considered a key feature of airways disease. No clinically accepted diagnostic method is currently available to assess airway remodeling or the effect of treatment modalities such as bronchial thermoplasty in asthma, other than invasive airway biopsies. Optical coherence tomography (OCT) generates cross-sectional, near-histological images of airway segments and enables identification and quantification of airway wall layers based on light scattering properties only. In this study, we used a custom motorized OCT probe that combines standard and polarization sensitive OCT (PS-OCT) to visualize birefringent tissue in vivo in ...

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    2. Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right middle lobe (RML). Methods: 15 severe asthma patients were treated with BT. During the third procedure, OCT imaging was performed in BT treated (sub)segmental airways in the upper lobes ...

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    3. Optical coherence tomography for identification and quantification of human airway wall layers

      Optical coherence tomography for identification and quantification of human airway wall layers

      Background High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based optical coherence tomography (OCT) is a novel imaging technique that combined with bronchoscopy generates highly detailed images of the airway wall. The aim of this study is to identify and quantify human airway wall layers both ex-vivo and in-vivo by OCT and correlate these to histology. Methods Patients with lung cancer, prior to lobectomy, underwent bronchoscopy including in-vivo OCT imaging. Ex-vivo OCT imaging was performed in the resected lung lobe after needle insertion for matching with histology. Airway ...

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    4. Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

      Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

      Purpose of review: Current imaging techniques (X-ray, computed tomography scan, ultrasound) have limitations in the identification and quantification of pulmonary diseases, in particular, on highly detailed level. The purpose of this review is to provide an overview of the current knowledge of innovative light- and laser-based imaging techniques that might fill this gap. Recent findings: Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are high-resolution imaging techniques, which, combined with bronchoscopy, provide 'near histology' detailed imaging of the airway wall, lung parenchyma, mediastinal lymph nodes, and pulmonary vasculature. This article reviews the technical background of OCT and CLE, summarizes ...

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    1-5 of 5
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  2. Topics in the News

    1. (4 articles) Academic Medical Center at the University of Amsterdam
    2. (3 articles) Daniël M. de Bruin
    3. (2 articles) Topcon Medical Systems
    4. (1 articles) National Institutes of Health
    5. (1 articles) University of Groningen
    6. (1 articles) VU University Amsterdam
    7. (1 articles) Johannes F. de Boer
    8. (1 articles) Abbot
    9. (1 articles) Lightlab C7 XR OCT Imaging System
    10. (1 articles) Tohoku University
    11. (1 articles) Duke University
    12. (1 articles) Massachusetts Institute of Technology
    13. (1 articles) Hiroshi Mashimo
    14. (1 articles) James G. Fujimoto
    15. (1 articles) Oscar Carrasco-Zevallos
    16. (1 articles) Joseph A. Izatt
    17. (1 articles) Thorlabs
    18. (1 articles) Topcon 3D OCT-2000
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    Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases Optical coherence tomography for identification and quantification of human airway wall layers Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT) In vivo multifunctional optical coherence tomography at the periphery of the lungs Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall Spectral Domain Optical Coherence Tomography Imaging Performance Improvement Based on Field Curvature Aberration-Corrected Spectrometer Pentosan polysulfate maculopathy versus inherited macular dystrophies: comparative assessment with multimodal imaging Complementary Use of Active Infrared Thermography and Optical Coherent Tomography in Non-destructive Testing Inspection of Ancient Marquetries Spectral domain optical coherence tomography–based prevalence of hydroxychloroquine maculopathy in Indian patients on hydroxychloroquine therapy: A utopia of underdiagnosis Consistency Between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes Tethered capsule en face optical coherence tomography for imaging Barrett’s esophagus in unsedated patients Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography