1. Articles from Jouke T. Annema

    1-7 of 7
    1. Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma

      Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma

      Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), including thickening of airway smooth muscle (ASM) as a key element of this alteration. 1 Patients with severe asthma may benefit from bronchial thermoplasty (BT), an endoscopic treatment that targets structural AR and induces ASM reduction. 2 Assessment of AR is critical to evaluate the impact of BT and might provide a tool for patient selection for BT. Polarization sensitive optical coherence tomography (PS-OCT) imaging has been proposed as a minimally invasive diagnostic method to assess ASM mass as an alternative to focal airway biopsies. Bronchoscopic standard optical coherence ...

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    2. 3D co-registration algorithm for catheter-based optical coherence tomography

      3D co-registration algorithm for catheter-based optical coherence tomography

      Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modality were developed for cardiovascular applications and with it, are tailored to small tubular tissue structures. The available algorithms can often not be applied outside the cardiovascular system, e.g. when an OCT probe is introduced into the kidney, lungs, or wrist. Here, we develop a generic co-registration algorithm with potentially numerous applications. This algorithm only requires that the OCT probe is visible on the second imaging modality and ...

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    3. In vivo multifunctional optical coherence tomography at the periphery of the lungs

      In vivo multifunctional optical coherence tomography at the periphery of the lungs

      Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is considered a key feature of airways disease. No clinically accepted diagnostic method is currently available to assess airway remodeling or the effect of treatment modalities such as bronchial thermoplasty in asthma, other than invasive airway biopsies. Optical coherence tomography (OCT) generates cross-sectional, near-histological images of airway segments and enables identification and quantification of airway wall layers based on light scattering properties only. In this study, we used a custom motorized OCT probe that combines standard and polarization sensitive OCT (PS-OCT) to visualize birefringent tissue in vivo in ...

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    4. Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right middle lobe (RML). Methods: 15 severe asthma patients were treated with BT. During the third procedure, OCT imaging was performed in BT treated (sub)segmental airways in the upper lobes ...

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    5. Optical coherence tomography for identification and quantification of human airway wall layers

      Optical coherence tomography for identification and quantification of human airway wall layers

      Background High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based optical coherence tomography (OCT) is a novel imaging technique that combined with bronchoscopy generates highly detailed images of the airway wall. The aim of this study is to identify and quantify human airway wall layers both ex-vivo and in-vivo by OCT and correlate these to histology. Methods Patients with lung cancer, prior to lobectomy, underwent bronchoscopy including in-vivo OCT imaging. Ex-vivo OCT imaging was performed in the resected lung lobe after needle insertion for matching with histology. Airway ...

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    6. Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

      Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

      Purpose of review: Current imaging techniques (X-ray, computed tomography scan, ultrasound) have limitations in the identification and quantification of pulmonary diseases, in particular, on highly detailed level. The purpose of this review is to provide an overview of the current knowledge of innovative light- and laser-based imaging techniques that might fill this gap. Recent findings: Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are high-resolution imaging techniques, which, combined with bronchoscopy, provide 'near histology' detailed imaging of the airway wall, lung parenchyma, mediastinal lymph nodes, and pulmonary vasculature. This article reviews the technical background of OCT and CLE, summarizes ...

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    1-7 of 7
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    1. (6 articles) Academic Medical Center at the University of Amsterdam
    2. (2 articles) VU University Amsterdam
    3. (1 articles) National Institutes of Health
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    Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases Optical coherence tomography for identification and quantification of human airway wall layers Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT) In vivo multifunctional optical coherence tomography at the periphery of the lungs Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall 3D co-registration algorithm for catheter-based optical coherence tomography Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma Automated Imaging of the Eye Within Arm’s Reach Racial and ethnic differences in foveal avascular zone in diabetic and nondiabetic eyes revealed by optical coherence tomography angiography Two 3-Year Post-Doc Research Associate Openings Biophotonics at University of Sheffield Longitudinal Assessment of Ellipsoid Zone Recovery using En Face Optical Coherence Tomography after Retinal Detachment Repair Stardust Sign and Retinal Tear detection on Swept-Source Optical Coherence Tomography