1. Articles from John N. Griffin

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    1. Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports

      Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports

      Birth defects affect 3% of children in the United States. Among the birth defects, congenital heart disease and craniofacial malformations are major causes of mortality and morbidity. Unfortunately, the genetic mechanisms underlying craniocardiac malformations remain largely uncharacterized. To address this, human genomic studies are identifying sequence variations in patients, resulting in numerous candidate genes. However, the molecular mechanisms of pathogenesis for most candidate genes are unknown. Therefore, there is a need for functional analyses in rapid and efficient animal models of human disease. Here, we coupled the frog Xenopus tropicalis with Optical Coherence Tomography (OCT) to create a fast and ...

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  2. Topics in the News

    1. (1 articles) Yale University
    2. (1 articles) Michael A. Choma
    3. (1 articles) Harvard University
    4. (1 articles) Massachusetts General Hospital
    5. (1 articles) University of North Carolina
    6. (1 articles) Baylor College of Medicine
    7. (1 articles) Masamichi Takano
    8. (1 articles) Joel S. Schuman
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