1. Articles from Yusi Miao

    1-10 of 10
    1. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface as well as the complex 3D anatomical shape. Previous studies indicate that changes in airway histopathology can be found in the OCT image almost immediately after inhalation of smoke and ...

      Read Full Article
    2. Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration

      Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration

      We present a very simple method of constructing a polarization-sensitive optical coherence tomography (PS-OCT) system. An ordinary fiber-based swept-source OCT system was reconfigured for PS-OCT by adding a long section of polarization-maintaining fiber in the sample arm. Two polarization modes of a large group-delay difference formed spatially distinguished polarization channels. The depth-encoded information on the polarization states was retrieved by an amplitude-based analysis. We found that our method provides an economic scheme of PS-OCT. It demonstrates that an ordinary OCT system can be easily reconfigured for PS-OCT imaging if it has sufficient margins in the imaging range.

      Read Full Article
    3. Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Background Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury with a mortality rate of up to 40%. Early management of ARDS has been difficult due to the lack of sensitive imaging tools and robust analysis software. We previously designed an optical coherence tomography (OCT) system to evaluate mucosa thickness (MT) post smoke inhalation, but the analysis relied on manual segmentation. The aim of this study is to assess in vivo proximal airway volume (PAV) after inhalation injury using automated OCT segmentation and correlate the PAV to lung function for rapid indication of ARDS. Methods Anesthetized ...

      Read Full Article
    4. 1.7 micron optical coherence tomography for vaginal tissue characterization in vivo

      1.7 micron optical coherence tomography for vaginal tissue characterization in vivo

      Objectives Optical coherence tomography (OCT) can noninvasively visualize in vivo tissue microstructure with high spatial resolution that approaches the histologic level. Currently, OCT studies in gynecology are few and limited to a conventional 1.3 μm center wavelength swept light source which provides high spatial resolution but limited penetration depth. Here, we present a novel endoscopic OCT system with improved penetration depth and high resolution. Methods A novel endoscopic OCT system was developed based on a 1.7 µm swept source laser, which is capable of deeper tissue penetration due to its longer wavelength. To evaluate the performance of system ...

      Read Full Article
    5. Deep imaging in highly scattering media by combining reflection matrix measurement with Bessel-like beam based optical coherence tomography

      Deep imaging in highly scattering media by combining reflection matrix measurement with Bessel-like beam based optical coherence tomography

      Multiple scattering in biomedical tissue limits the imaging depth within a range of 1–2 mm for conventional optical imaging techniques. To extend the imaging depth into the scattering medium, a computational method based on the reflection matrix measurement has been developed to retrieve the singly back-scattered signal light from the dominant detrimental multiple-scattered background. After applying singular value decomposition on the measured matrix in the post-process, the target image underneath the turbid media is clearly recovered. To increase the depth of focus of the incident light by elongating the focal spot along the optical axis, a digital grating pattern ...

      Read Full Article
    6. Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography

      Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography

      Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from harmless ones. Many methods focus on the structural or molecular properties of plaques. Mechanical properties have been shown to change drastically when abnormalities develop in arterial tissue. We report the development of an acoustic radiation force optical coherence elastography (ARF-OCE) system that uses an integrated miniature ultrasound and optical coherence tomography (OCT) probe to map the ...

      Read Full Article
    7. Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography

      Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography

      Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Using shear wave elastography, the shear modulus of a soft tissue can be quantified by tracking the shear wave propagation. In previous measurements, the transverse shear wave propagates perpendicular to the force direction, so the shear modulus in the lateral region of the force can be quantified. However, the shear modulus in the axial region of the force cannot be measured. Dr. Jiang ...

      Read Full Article
    8. Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography

      Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography

      Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Previous transverse shear wave measurements could detect the shear modulus in the lateral region of the force; however, they could not provide the elastic information in the axial region of the force. In this study, we report the imaging and quantification of longitudinal shear wave propagation using optical coherence tomography to measure the elastic properties along the force direction. The experimental validation and ...

      Read Full Article
    9. Fully integrated optical coherence tomography, ultrasound, and indocyanine green-based fluorescence tri-modality system for intravascular imaging

      Fully integrated optical coherence tomography, ultrasound, and indocyanine green-based fluorescence tri-modality system for intravascular imaging

      We present a tri-modality imaging system and fully integrated tri-modality probe for intravascular imaging. The tri-modality imaging system is able to simultaneously acquire optical coherence tomography (OCT), ultrasound (US), and fluorescence imaging. Moreover, for fluorescence imaging, we used the FDA-approved indocyanine green (ICG) dye as the contrast agent to target lipid-loaded macrophages. We conducted imaging from a male New Zealand white rabbit to evaluate the performance of the tri-modality system. In addition, tri-modality images of rabbit aortas were correlated with hematoxylin and eosin (H&E) histology to check the measurement accuracy. The fully integrated miniature tri-modality probe, together with the ...

      Read Full Article
    10. 3D mapping of elastic modulus using shear wave optical micro-elastography

      3D mapping of elastic modulus using shear wave optical micro-elastography

      lastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves. In this study, we developed acoustic radiation force (ARF) orthogonal excitation optical coherence elastography (ARFOE-OCE) to visualize shear waves in 3D. This ...

      Read Full Article
    1-10 of 10
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (10 articles) UC Irvine
    2. (10 articles) Zhongping Chen
    3. (6 articles) Jiang Zhu
    4. (3 articles) Yan Li
    5. (3 articles) Qifa Zhou
    6. (2 articles) Matthew Brenner
    7. (2 articles) Joseph C. Jing
    8. (2 articles) Cuixia Dai
    9. (1 articles) University of Southern California
    10. (1 articles) K. Kirk Shung
  3. Popular Articles

  4. Picture Gallery

    Fully integrated optical coherence tomography, ultrasound, and indocyanine green-based fluorescence tri-modality system for intravascular imaging 3D mapping of elastic modulus using shear wave optical micro-elastography Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography Feature of The Week 05/19/2017: Longitudinal Shear Wave Imaging for Elasticity Mapping Using Optical Coherence Elastography Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography Deep imaging in highly scattering media by combining reflection matrix measurement with Bessel-like beam based optical coherence tomography 1.7 micron optical coherence tomography for vaginal tissue characterization in vivo Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review Remote scanning for ultra-large field of view in wide-field microscopy and full-field OCT Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability