1. Articles from Jean-Luc Perrot

    1-9 of 9
    1. Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders

      Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders

      Background: The spectrum of pustular skin disorders (PSD) is large and particularly challenging, including inflammatory, infectious and amicrobial diseases. Moreover, although pustules represent the unifying clinical feature, they can be absent or not fully developed in the early stage of the disease. The line-field confocal optical coherence tomography (LC-OCT) is a recently developed imaging technique able to perform a non-invasive, in vivo, examination of the epidermis and upper dermis, reaching very high image resolution and virtual histology. Objectives: We aimed to investigate the potentialities of LC-OCT in the non-invasive differential diagnosis of a series of 11 PSD with different etiology ...

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    2. Co-localized line-field confocal optical coherence tomography and confocal Raman microspectroscopy for three-dimensional high-resolution morphological and molecular characterization of skin tissues ex vivo

      Co-localized line-field confocal optical coherence tomography and confocal Raman microspectroscopy for three-dimensional high-resolution morphological and molecular characterization of skin tissues ex vivo

      Line-field confocal optical coherence tomography (LC-OCT) is an optical modality that provides three-dimensional (3D) images of the skin at cellular resolution. Confocal Raman microspectroscopy (CRM) is a label-free optical technique that can provide point measurement of the molecular content of the skin. This work presents a method to co-localize LC-OCT and CRM acquisitions for morpho-molecular analysis of ex vivo skin tissues at cellular level. The co-localization method allows acquisition of Raman spectra at specific locations in a sample identified from a 3D LC-OCT image, with an accuracy of ± 20 µm. The method was applied to the characterization of tattooed skin ...

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    3. Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning

      Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning

      Diagnosis based on histopathology for skin cancer detection is today's gold standard and relies on the presence or absence of biomarkers and cellular atypia. However it suffers drawbacks: it requires a strong expertise and is time-consuming. Moreover the notion of atypia or dysplasia of the visible cells used for diagnosis is very subjective, with poor inter-rater agreement reported in the literature. Lastly, histology requires a biopsy which is an invasive procedure and only captures a small sample of the lesion, which is insufficient in the context of large fields of cancerization. Here we demonstrate that the notion of cellular ...

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    4. Line-field confocal optical coherence tomography of actinic keratosis: a case series

      Line-field confocal optical coherence tomography of actinic keratosis: a case series

      Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique that was recently developed, combining high penetration depth (up to 500-µm, approaching that of conventional OCT) with high isotropic resolution [lateral: 1.3 µm; axial: 1.1 µm - similar to that of reflectance confocal microscopy (RCM)]. 1 .

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    5. Line-field confocal optical coherence tomography of sebaceous hyperplasia: a case series

      Line-field confocal optical coherence tomography of sebaceous hyperplasia: a case series

      Line-field confocal optical coherence tomography (LC-OCT) is a newly developed non-invasive imaging technique that combines high penetration depth (500 µm, similar to conventional OCT) with high isotropic resolution (lateral 1.3 µm, axial 1.1 µm, similar to reflectance confocal microscopy [RCM]). 1 Moreover, with its ability to produce images in both vertical and horizontal planes, it enables a tridimensional (3D) analysis of the skin, which can prove very useful for assessing physiological 2 as well as pathological skin.

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    6. Line-field confocal optical coherence tomography for three-dimensional skin imaging

      Line-field confocal optical coherence tomography for three-dimensional skin imaging

      This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal ( x × y ) section images at an adjustable depth or vertical ( x × z ) section images at an adjustable lateral position, as well as three-dimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions. Three-dimensional ( x × y × z ) images are acquired from a stack of horizontal section images. The device is in the form of a portable probe. The handle of the probe has ...

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    7. Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

      Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

      An optical technique called line-field confocal optical coherence tomography (LC-OCT) is introduced for high-resolution, noninvasive imaging of human skin in vivo . LC-OCT combines the principles of time-domain optical coherence tomography and confocal microscopy with line illumination and detection using a broadband laser and a line-scan camera. LC-OCT measures the echo-time delay and amplitude of light backscattered from cutaneous microstructures through low-coherence interferometry associated with confocal spatial filtering. Multiple A-scans are acquired simultaneously while dynamically adjusting the focus. The resulting cross-sectional B-scan image is produced in real time at 10  frame  /  s. With an isotropic spatial resolution of ∼1  μm, the ...

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      Mentions: Damae Medical
    8. Advances in optical coherence tomography for dermatology

      Advances in optical coherence tomography for dermatology

      This paper reports on advances in optical coherence tomography (OCT) for application in dermatology. Full-field OCT is a particular approach of OCT based on white-light interference microscopy. FF-OCT produces en face tomographic images by arithmetic combination of interferometric images acquired with an area camera and by illuminating the whole field of view with low-coherence light. The major interest of FF-OCT lies in its high imaging spatial resolution (∼ 1.0 µm) in both lateral and axial directions, using a simple and robust experimental arrangement. Line-field OCT (LFOCT) is a recent evolution of FF-OCT with line illumination and line detection using a ...

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    1-9 of 9
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  2. Topics in the News

    1. (2 articles) Damae Medical
    2. (1 articles) University of Rochester
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    Dermoscopy, reflectance confocal microscopy, and high-definition optical coherence tomography in the diagnosis of generalized argyria Advances in optical coherence tomography for dermatology Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors Line-field confocal optical coherence tomography for three-dimensional skin imaging Line-field confocal optical coherence tomography of sebaceous hyperplasia: a case series Line-field confocal optical coherence tomography of actinic keratosis: a case series Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning Co-localized line-field confocal optical coherence tomography and confocal Raman microspectroscopy for three-dimensional high-resolution morphological and molecular characterization of skin tissues ex vivo Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders Cascade Optical Coherence Tomography (C-OCT) for Surface Form Metrology of - ProQuest Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work