1. Articles from Jianlong Yang

    1-7 of 7
    1. Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may be used as noninvasive imaging modalities for IP and similar retinal vascular disorders in supine young children.

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    2. Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti

      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder that can cause retinal nonperfusion, neovascularization, and retinal detachment. Evaluation of the peripheral retinal vasculature and appropriate treatment can reduce the risk of blindness. The authors report the use of a handheld prototype optical coherence tomography angiography (OCTA) and ultra-widefield OCT (UWF-OCT) during exam under anesthesia of a 2-year-old with a history of severe early onset IP. UWF-OCT and OCTA may be used as noninvasive imaging modalities for IP and similar retinal vascular disorders in supine young children.

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    3. Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography

      Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography

      A polarization-multiplexed, dual-beam setup is proposed to expand the field of view for a swept source optical coherence tomography angiography (OCTA) system. This method used a Wollaston prism to split sample path light into two orthogonal-polarized beams. This allowed two beams to shine on the cornea at an angle separation of ~ 14 degrees, which led to a separation of ~ 4.2 mm on the retina. A 3-mm glass plate was inserted into one of the beam paths to set a constant path length difference between the two polarized beams so the interferogram from the two beams are coded at different ...

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    4. Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Importance Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultra–wide-field OCT or OCTA images in neonates. Objective To obtain ultra–wide-field OCT and OCTA images in neonates with ROP using a prototype handheld OCT and OCTA device. Design, Setting, and Participants This observational case series was conducted ...

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    5. Extended axial imaging range, widefield swept source optical coherence tomography angiography

      Extended axial imaging range, widefield swept source optical coherence tomography angiography

      We developed a high-speed, swept source OCT system for widefield OCT angiography (OCTA) imaging. The system has an extended axial imaging range of 6.6 mm. An electrical lens is used for fast, automatic focusing. The recently developed split-spectrum amplitude and phase-gradient angiography allow high-resolution OCTA imaging with only two B-scan repetitions. An improved post-processing algorithm effectively removed trigger jitter artifacts and reduced noise in the flow signal. We demonstrated high contrast 3 mm×3 mm OCTA image with 400×400 pixels acquired in 3 seconds and high-definition 8 mm×6 mm and 12 mm×6 mm OCTA images with ...

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    6. Handheld optical coherence tomography angiography

      Handheld optical coherence tomography angiography

      We developed a handheld optical coherence tomography angiography (OCTA) system using a 100-kHz swept-source laser. The handheld probe weighs 0.4 kg and measures 20.6 × 12.8 × 4.6 cm 3 . The system has dedicated features for handheld operation. The probe is equipped with a mini iris camera for easy alignment. Real-time display of the en face OCT and cross-sectional OCT images in the system allows accurately locating the imaging target. Fast automatic focusing was achieved by an electrically tunable lens controlled by a golden-section search algorithm. An extended axial imaging range of 6 mm allows easy alignment. A ...

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    7. Hematocrit dependence of flow signal in optical coherence tomography angiography

      Hematocrit dependence of flow signal in optical coherence tomography angiography

      The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and blood vessels, the normal hematocrit is near the decorrelation saturation point and therefore a change in hematocrit has little effect on the SSADA decorrelation value (flow signal). However, in narrow ...

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    1-7 of 7
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    1. (7 articles) Center for Ophthalmic Optics and Lasers
    2. (7 articles) Oregon Health & Science University
    3. (7 articles) David Huang
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    Hematocrit dependence of flow signal in optical coherence tomography angiography Handheld optical coherence tomography angiography Extended axial imaging range, widefield swept source optical coherence tomography angiography Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti Optical Coherence Tomography Angiography and UltraWidefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti Notal Vision Engages Wasatch Photonics Bringing AI-Enabled Home-Based Optical Coherence Tomography Closer to Market Semiconductor Lasers and Diode-based Light Sources for Biophotonics (Textbook) Inside the “Razor Effect”: Lessons From Optical Coherence Tomography—What Does Angiography Hide? Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice