1. Articles from Tongtong Wu

    1-2 of 2
    1. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

      Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

      Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney microstructures in vivo without administering exogenous contrast agents. A murine model of CKD induced by intravenous Adriamycin (ADR) injection is evaluated by OCT. OCT images of the rat kidneys have ...

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    2. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Maryland
    2. (2 articles) Carl Zeiss Meditec
    3. (1 articles) Harvard University
    4. (1 articles) University of Rochester
    5. (1 articles) Hiroshi Mashimo
    6. (1 articles) Chao-Wei Chen
    7. (1 articles) Haoyu Chen
    8. (1 articles) Yu Chen
    9. (1 articles) University of Missouri
    10. (1 articles) Johns Hopkins University
    11. (1 articles) Technical University of Munich
    12. (1 articles) UCSD
    13. (1 articles) University of Cambridge
    14. (1 articles) University of Rochester
    15. (1 articles) Gang Yao
    16. (1 articles) Taiji Sakamoto
    17. (1 articles) Heidelberg Engineering
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