1. Articles from Jonathan Lin

    1-2 of 2
    1. 3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo

      3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo

      As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR light, PIT can induce highly-selective cancer cell death while leaving most of tumor blood vessels unharmed, leading to an effect termed super-enhanced permeability and retention (SUPR), which can significantly improve the effectiveness of anti-cancer drug. Currently, the therapeutic effects of PIT are monitored using 2D macroscopic fluorescence reflectance imager, which lacks the resolution and depth information to ...

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    2. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Maryland
    2. (2 articles) Carl Zeiss Meditec
    3. (1 articles) Harvard University
    4. (1 articles) FDA
    5. (1 articles) University of Rochester
    6. (1 articles) Chao-Wei Chen
    7. (1 articles) Haoyu Chen
    8. (1 articles) Hiroshi Mashimo
    9. (1 articles) Yu Chen
    10. (1 articles) University of Missouri
    11. (1 articles) Johns Hopkins University
    12. (1 articles) Technical University of Munich
    13. (1 articles) UCSD
    14. (1 articles) University of Cambridge
    15. (1 articles) University of Rochester
    16. (1 articles) Gang Yao
    17. (1 articles) Taiji Sakamoto
    18. (1 articles) Heidelberg Engineering
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