1. Articles from A. L. Oldenburg

    1-3 of 3
    1. Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

      Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

      The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disorder (COPD), mucus hydration is impaired, resulting in high wt%. Mucus with high wt% is a hallmark of pulmonary disease that leads to obstructed airways, inflammation, and infection. Methods to measure mucus hydration in situ and in real-time are needed for drug development and personalized therapy. We employed plasmonic gold nanorod (GNR) biosensors that intermittently collide with macromolecules comprising the mucus mesh as they self-diffuse, such that GNR translational diffusion ( D T ) is sensitive ...

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    2. Spectroscopic Optical Coherence Tomography and Microscopy

      Imaging biological tissues using optical coherence tomography is enhanced with spectroscopic analysis, providing new metrics for functional imaging. Recent advances in spectroscopic optical coherence tomography (SOCT) include techniques for the discrimination of endogenous tissue types and for the detection of exogenous contrast agents. In this paper, we review these techniques and their associated signal processing algorithms, while highlighting their potential for biomedical applications. We unify the theoretical framework for time- and frequency-domain SOCT and introduce a noise correction method. Differences between spectroscopic Mie scatterers are demonstrated with SOCT, and spectroscopic imaging of macrophage and fibroblast cells in a 3-D scaffold ...
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    3. Optical coherence tomography: a review of clinical development from bench to bedside

      Adam M. Zysk, Freddy T. Nguyen, Amy L. Oldenburg et al. Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging ... [J. Biomed. Opt. 12, 051403 (2007)] published Wed Oct 24, 2007.
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Amy L. Oldenburg
    2. (2 articles) University of Illinois at Urbana-Champaign
    3. (2 articles) Stephen A. Boppart
    4. (1 articles) University of North Carolina
    5. (1 articles) Richard L. Blackmon
    6. (1 articles) Daniel L. Marks
    7. (1 articles) ESPCI ParisTech
    8. (1 articles) Michalina J. Góra
    9. (1 articles) Claude Boccara
    10. (1 articles) Cylite
    11. (1 articles) LLTech
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