All Articles from Sebastian Wolf -Optical Coherence Tomography News

Articles from Sebastian Wolf

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1. AUTOMATED RETINAL LAYER SEGMENTATION AND THEIR THICKNESS PROFILES IN HEALTHY SUBJECTS: A Comparison of 55° Wide-field and Conventional 30° Spectral Domain-Optical Coherence Tomography
  
  Explore LWW Online Sep 23 2020 Ophthalmology
  
  Purpose: To assess whether retinal thickness measurements with a standard 30° spectral domain optical coherence tomography (SD- OCT ) are comparable with wide-field 55° SD- OCT . Methods: Thirty-three healthy individuals were scanned using 55° as well as 30° SD- OCT according to a standardized protocol. Automated retinal layer segmentation of standard and wide-field SD-OCTs was assessed using customized software. Results: Both lenses showed a high correlation when analyzing total retinal thickness within the central, the inner, and the outer retinal ring (r = > 0.9). Automated thickness measurements with the 55° system were marginally higher compared with the 30° lens. The thickness ...
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  Mentions: Heidelberg Engineering Sebastian Wolf University of Bern
2. Comparison of Drusen Volume Assessed by Two Different OCT Devices
  
  Explore MDPI Open Access Journals Platform Aug 23 2020 Ophthalmology
  
  To compare drusen volume between Heidelberg Spectral Domain (SD-) and Zeiss Swept-Source (SS) PlexElite Optical Coherence Tomography (OCT) determined by manual and automated segmentation methods. Thirty-two eyes of 24 patients with Age-Related Macular Degeneration (AMD) and drusen maculopathy were included. In the central 1 and 3 mm ETDRS circle drusen volumes were calculated and compared. Drusen segmentation was performed using automated manufacturer algorithms of the two OCT devices. Then, the automated segmentation was manually corrected and compared and finally analyzed using customized software. Though on SD-OCT, there was a significant difference of mean drusen volume prior to and after manual ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
3. Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy
  
  Explore Wiley Online Library Nov 4 2019 Ophthalmology
  
  Purpose To compare different Swept‐Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy (DR), to find the most suitable slab for grading. Methods Retrospective cross‐sectional study. Consecutive patients with DR were evaluated using SS‐OCTA. The central 12 × 12 mm scan was used to generate the retinal, superficial and deep slab. The grading results of the slabs were then compared to determine if one specific slab is superior to detect respective features. Results A total of 348 eyes (190 patients; mean age 58.1 ± 14.5 years) were graded for features ...
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  Mentions: Sebastian Wolf
4. Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans
  
  Explore Nature Publishing Group Sep 24 2019 Ophthalmology
  
  In ophthalmology, retinal biological markers, or biomarkers , play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic retinal conditions, the quantity of scans acquired worldwide is surpassing the capacity of retinal specialists to inspect these in meaningful ways. Instead, automated analysis of scans using machine learning algorithms ...
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  Mentions: Sebastian Wolf University of Bern Martin S. Zinkernagel
5. Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina
  
  Explore TVST Journal May 7 2019 Ophthalmology
  
  Purpose : We evaluated the repeatability of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Methods : Healthy subjects underwent two imaging sessions, on average 8 days apart, with a 100 kHz SS-OCTA instrument. The imaging protocol included a central 3 × 3 and 12 × 12 mm scans of the four quadrants resulting in more than a 70° wide-field OCTA of the posterior pole. Quantitative analysis was performed using the inbuilt Macular Density Algorithm Version v0.6.1 and AngioTool software. Consistency for the foveal avascular zone (FAZ), vessel density, and perfusion density of the superficial and deep capillary ...
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  Mentions: University of Bern Bern University Hospital
6. Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software
  
  Explore TVST Journal May 7 2019 Ophthalmology
  
  Purpose : We investigate which spectral domain-optical coherence tomography (SD-OCT) setting is superior when measuring subfoveal choroidal thickness (CT) and compared results to an automated segmentation software. Methods : Thirty patients underwent enhanced depth imaging (EDI)-OCT. B-scans were extracted in six different settings (W+N = white background/normal contrast 9; W+H = white background/maximum contrast 16; B+N = black background/normal contrast 12; B+H = black background/maximum contrast 16; C+N = Color-encoded image on black background at predefined contrast of 9, and C+H = Color-encoded image on black background at high/maximal contrast of 16), resulting in 180 images ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
7. Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis
  
  Explore Wiley Online Library Feb 13 2019 Ophthalmology
  
  Purpose To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept‐source optical coherence tomography angiography (OCTA). Methods In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age‐matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated. Results 93 eyes of 58 patients with intermediate uveitis and 33 healthy age‐matched controls were included. The presence of a cystoid ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
8. Vascular Abnormalities In Diabetic Retinopathy Assessed With SWEPT-SOURCE Optical Coherence Tomography Angiography Widefield Imaging
  
  Explore LWW Online Dec 22 2018 Ophthalmology
  
  Purpose: To detect vascular abnormalities in diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) widefield images, and to compare the findings with color fundus photographs (CFPs) using Early Treatment Diabetic Retinopathy Study severity grading. Methods: 3 mm × 3 mm and 12 mm × 12 mm scans were acquired to cover 70° to 80° of the posterior pole using a 100-kHz SS-OCTA instrument. Two masked graders assessed the presence of vascular abnormalities on SS-OCTA and the Early Treatment Diabetic Retinopathy Study level on CFP. The grading results were then compared. Results: A total of 120 diabetic eyes (60 patients) were imaged ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
9. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography
  
  Explore BJO Online Dec 15 2018 Ophthalmology
  
  Purpose To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). Methods This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort. Results 164 eyes of 88 patients with intermediate uveitis were included. Areas of capillary non-perfusion and reduced perfusion were more ...
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  Mentions: University of Bern Bern University Hospital
10. Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging
  
  Explore Journals | PLOS Oct 9 2018 Ophthalmology
  
  Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. Results Thirteen eyes of 12 patients met the inclusion criteria. There was ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
11. The European Eye Epidemiology spectral‐domain optical coherence tomography classification of macular diseases for epidemiological studies
  
  Explore Wiley Online Library Sep 22 2018 Ophthalmology
  
  The E3 consortium thanks Cécile Delcourt, Jean‐François Korobelnik, Marie‐Bénédicte Rougier and Marie‐Noëlle Delyfer for organizing the meetings in Bordeaux in 2011, 2012 and 2013, Stefano Piermarocchi for organizing the meeting in Rome in 2014, Chris Hammond, Paul Foster and Tunde Peto for organizing the meeting in London in 2015. These workshops have received financial support from Carl Zeiss Meditec AG, Laboratoires Théa, Novartis and OOgroup. The sponsors had no role in the design or conduct of this research.Pr. Schmitz‐Valckenberg reports grants and personal fees from Allergan, Bayer, Genentech/Roche ...
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  Mentions: Heidelberg Engineering Topcon Medical Systems Carl Zeiss Meditec
12. Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration
  
  Explore SAGE Journals Feb 6 2018 Ophthalmology
  
  Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes) from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert (control eyes). Parameters related to drusen, pigment epithelium detachment, hyperreflective foci (HRF), retinal pigment epithelium atrophy, small cystic cavities, and vitreoretinal interface were graded. Longitudinal analysis in study eyes and cross-sectional comparison with control eyes ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
13. OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices
  
  Explore Journals | PLOS May 10 2017
  
  Article Authors Metrics Comments Related Content Abstract Introduction Methods Results Discussion Supporting information Acknowledgments Author Contributions References Reader Comments (0) Media Coverage Figures Abstract Purpose To compare the quality of four OCT-angiography(OCT-A) modules. Method The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment ...
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  Mentions: Optovue Heidelberg Engineering Nidek
14. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF TORPEDO MACULOPATHY
  
  Explore LWW Online Apr 8 2017 Ophthalmology
  
  Background/Purpose: To investigate the retinal and choroidal vasculature in patients with torpedo maculopathy with optical coherence tomography-angiography (OCT-A). Methods: Retrospective case series of four patients who were examined at the department of Ophthalmology at the University Hospital Bern. Main Outcome was the lesion size over time in OCT-A and fundus autofluorescence. Results: Three patients had Type I and 1 patient had Type II torpedo maculopathy. Torpedo maculopathy lesion size remained stable in all patients over a mean period of observation of three years in OCT-A and fundus autofluorescence. The choriocapillaris network was attenuated focally within the lesion in OCT-A ...
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  Mentions: Sebastian Wolf Martin S. Zinkernagel
15. Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography
  
  Explore TVST Journal Aug 23 2016 Ophthalmology
  
  Purpose : Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. Methods : In the present study, OCT-A based on a Heidelberg Engineering Spectralis system was used to investigate the vascular network in mice. Data was compared with FA and confocal microscopy of flat-mount histology stained with isolectin IB4. For quantitative analysis the National Cancer Institute's AngioTool software was used. Vessel density, the number of vessel junctions, and endpoints were measured and compared between the imaging ...
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  Mentions: National Cancer Institute Sebastian Wolf Bern University Hospital
16. Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration
  
  Explore IOVS Journal Jul 14 2016 Ophthalmology
  
  Purpose : To analyze inner retinal changes in patients with geographic atrophy (GA) secondary to age-related macular degeneration and identify morphological cues for progression. Methods : A total of 100 eyes with GA were assessed in this longitudinal, observational case series. Patients with GA and absent confounding pathology were compared with age-matched controls. The retinal layers on spectral-domain optical coherence tomography, acquired in tracking mode, were segmented manually on central scans through the fixation point. Zones of GA were defined based on choroidal signal enhancement from retinal pigment epithelium loss. An area of unaffected temporal retina was used for comparison. Progression of ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
17. Automatic assessment of time-resolved OCT images for selective retina therapy
  
  Explore Home - Springer Apr 21 2016 Ophthalmology
  
  Purpose In recent years, selective retina laser treatment (SRT), a sub-threshold therapy method, avoids widespread damage to all retinal layers by targeting only a few. While these methods facilitate faster healing, their lack of visual feedback during treatment represents a considerable shortcoming as induced lesions remain invisible with conventional imaging and make clinical use challenging. To overcome this, we present a new strategy to provide location-specific and contact-free automatic feedback of SRT laser applications. Methods We leverage time-resolved optical coherence tomography (OCT) to provide informative feedback to clinicians on outcomes of location-specific treatment. By coupling an OCT system to SRT ...
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  Mentions: Sebastian Wolf University of Bern Patrick Steiner
18. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy
  
  Explore IOVS Journal Oct 27 2015 Ophthalmology
  
  Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial resolution of 1.78 μm was combined with an SRT system and time-resolved OCT M-scans of the target area were recorded from four patients undergoing SRT. Optical coherence tomography scans ...
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  Mentions: Sebastian Wolf University of Bern Boris Považay
19. Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina
  
  Explore Conference Proceedings Mar 10 2015 Neurology , Ophthalmology
  
  Retinal laser photocoagulation is an established and successful treatment for a variety of retinal diseases. While being a valuable treatment modality, laser photocoagulation shows the drawback of employing high energy lasers which are capable of physically destroying the neural retina. For reliable therapy, it is therefore crucial to closely monitor the therapy effects caused in the retinal tissue. A depth resolved representation of optical tissue properties as provided by optical coherence tomography may provide valuable information about the treatment effects in the retinal layers if recorded simultaneously to laser coagulation. Therefore, in this work, the use of ultra-high resolution optical ...
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  Mentions: Sebastian Wolf University of Bern Christoph Meier
20. Senile scleral plaques imaged with enhanced depth optical coherence tomography
  
  Explore Wiley Online Library Oct 3 2014 Ophthalmology
  
  Purpose Senile scleral plaques (SSP) are sharply demarcated greyish areas located just anterior to the insertions of the horizontal rectus muscles and thus are frequently encountered during transscleral intravitreal injections. The aim of this study was to characterize SSP using enhanced depth imaging spectral domain anterior segment optical coherence tomography (OCT) in a cohort of patients attending intravitreal injection clinics. Methods Prospective cross-sectional study of 380 patients attending the clinic for intravitreal injections at the Department of Ophthalmology at the Bern University Hospital. Thirty-two patients with SSP were identified and the anatomical features were assessed using anterior segment OCT. Results ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
21. Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT
  
  Explore iovs.org Sep 6 2014 Ophthalmology
  
  Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. Methods: OCT scans of patients after successful macula-off RD repair were re-analyzed with a sub-segmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow up period after surgery of up to 7 weeks (range 21 to 49 days). In group 2 the follow up was > 8 weeks (range 60 to 438 days ...
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  Mentions: Sebastian Wolf University of Bern University of Hannover
22. Spectral-domain Optical Coherence Tomography Findings after Severe Exogenous Endophthalmitis
  
  Explore Informa Healthcare Sep 3 2014 Ophthalmology
  
  Purpose : To report outcomes and assess structural changes in the retina in patients with severe endophthalmitis . Methods : Retrospective, nonrandomized, interventional case series at a tertiary referral centre. Spectral domain optical coherence tomography (OCT) images of both eyes were acquired at least 5 months after pars plana vitrectomy. OCT images were analyzed using retinal layer segmentation. Results : Nine patients (46–80 years of age) were included in this study. Average ETDRS visual acuity before treatment was 23 letters and improved to 74 letters. In our cohort we did not find a generalized reduction of retinal layers using automated layer segmentation. Conclusion ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
23. Optical Coherence Tomography (Book Chapter)
  
  Explore SpringerLink Home Sep 7 2012 Ophthalmology , Textbooks
  
  Advances of fundus images have resulted in better understanding of age-related macular degeneration (AMD) in the past.
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  Mentions: Sebastian Wolf University of Bern
24. Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema
  
  Explore iovs.org Aug 25 2012 Ophthalmology
  
  Purpose. Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen in wet age-related macular degeneration (AMD), although the origin is still unknown; however, they reduced significantly during anti-VEGF (vascular endothelial growth factor) therapy, and their baseline amount seemed to correlate with treatment success. In this study the behavior of HFs was evaluated during anti-VEGF therapy for DME. Methods. Fifty-one patients (mean age: 67 years) underwent SD-OCT before and one month after one anti-VEGF injection (ranibizumab: n = 30; bevacizumab: n = 21). The HFs were ...
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  Mentions: Sebastian Wolf University of Bern Carsten Framme
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