1. Articles from Gavin S. W. Tan

    1-5 of 5
    1. Hints for Gentle Submacular Injection in Non-Human Primates Based on Intraoperative OCT Guidance

      Hints for Gentle Submacular Injection in Non-Human Primates Based on Intraoperative OCT Guidance

      Purpose: Delivery of Advanced Therapy Medicinal Products to the submacular space is increasingly evolving into a therapeutic modality. Cell replacement for age-related macular degeneration (AMD) and gene therapy for RPE65 are recent successful examples. Herein, a nonhuman primate (NHP) model was used to investigate surgical means to detach the macula. Methods: Sixteen eyes of 13 healthy macaques underwent a 25-gauge vitrectomy and subretinal injection of balanced salt solution monitored by microscope-integrated intraoperative optical coherence tomography (miOCT). The animals were followed with OCT and histology. Results: The miOCT monitoring allowed a more precise definition of surgical trauma ranging from an initial ...

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    2. Diabetic Macular Ischemia: Influence of Optical Coherence Tomography Angiography Parameters on Changes in Functional Outcomes Over One Year

      Diabetic Macular Ischemia: Influence of Optical Coherence Tomography Angiography Parameters on Changes in Functional Outcomes Over One Year

      Purpose : To prospectively evaluate whether diabetic macular ischemia detected with coherence tomography angiography (OCTA) is associated with change in functional outcomes over a period of one year. Methods : This is a one-year prospective, observational study that included 56 eyes with varying levels of diabetic retinopathy. All participants underwent best corrected visual acuity evaluation, swept-source OCTA and microperimetry at baseline and repeated at one year. Parafoveal vessel densities (VD) and foveal avascular zone (FAZ) areas were generated from OCTA in the superficial and deep vascular plexuses. The influence of baseline and change in OCTA parameters on change in visual acuity and ...

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    3. DIABETIC MACULAR ISCHEMIA Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit

      DIABETIC MACULAR ISCHEMIA Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit

      Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry . Optical coherence tomography angiography parameters and retinal sensitivity were correlated. Results: Deep perifoveal vessel density decreased with increasing severity of DR (adjusted mean 51.93 vs. 49.89 vs. 47.96, P -trend = 0.005). Superficial and deep foveal avascular zone area increased with increasing DR severity (adjusted ...

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    4. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

      Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

      Purpose Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements. Methods We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. The parafoveal vessel density within a 1.5 mm radius centred over the fovea was obtained with the built-in tool for the superficial and deep retinal plexuses. Repeatability of vessel density was determined by intraclass correlation ...

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    5. An anomaly detection approach for the identification of DME patients using spectral domain optical coherence tomography images

      An anomaly detection approach for the identification of DME patients using spectral domain optical coherence tomography images

      This paper proposes a method for automatic classification of spectral domain OCT data for the identification of patients with retinal diseases such as Diabetic Macular Edema (DME). We address this issue as an anomaly detection problem and propose a method that not only allows the classification of the OCT volume, but also allows the identification of the individual diseased B-scans inside the volume. Our approach is based on modeling the appearance of normal OCT images with a Gaussian Mixture Model (GMM) and detecting abnormal OCT images as outliers. The classification of an OCT volume is based on the number of ...

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    1-5 of 5
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    1. (4 articles) Singapore Eye Research Institute
    2. (2 articles) National University of Singapore
    3. (1 articles) The Chinese University of Hong Kong
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    An anomaly detection approach for the identification of DME patients using spectral domain optical coherence tomography images Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography DIABETIC MACULAR ISCHEMIA Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit Diabetic Macular Ischemia: Influence of Optical Coherence Tomography Angiography Parameters on Changes in Functional Outcomes Over One Year Hints for Gentle Submacular Injection in Non-Human Primates Based on Intraoperative OCT Guidance Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea Postdoctoral Position in Advanced Ophthalmic imaging at Johns Hopkins Revealing how maltodextrin-containing droplets dry using optical coherence tomography Repeatability and Agreement of Two Swept-Source Optical Coherence Tomographers for Anterior Segment Parameter Measurements Machine Learning Utility for Optical Coherence Tomography in Multiple Sclerosis: Is the Future Now? The Role of OCT Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis Ray Tracing versus Thin-Lens Formulas for IOL Power Calculation Using Swept-Source Optical Coherence Tomography Biometry