1. Articles from E. V. Gubarkova

    1-4 of 4
    1. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24 hours/3–12 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling error and better therapy regimen selection. Post-treatment OCA images at 24 hours were 98% predictive of eventual outcome. Additional findings highlight the importance of pre-treatment necrotic core, vascular ...

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    2. Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy

      Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy

      The aim of the study is to demonstrate the potential of cross-polarization optical coherence tomography (CP OCT) as a minimally invasive real-time technique for detection of bladder cancer against a background of severe inflammation. Materials and Methods. For the verification of CP OCT diagnostic data related to the condition of collagen comparison with high-resolution microscopy inspection was performed and correlation of the results was calculated. The CP OCT study was performed on samples of tissue with muscle-invasive urothelial carcinoma T 2–3 N 0–х M 0 (G2, 3) in 18 patients ranging in age from 50 to 64 obtained ...

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    3. Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages

      Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages

      The aim of the investigation was to develop an approach to quantitative evaluation of polarization properties (birefringence and cross-scattering) basing on cross-polarization OCT images (CP OCT) in order to characterize the development stages of atherosclerotic plaques and to reveal unstable ones. Materials and Methods. We report on quantitative analysis of CP OCT images of the seven development stages of atherosclerotic plaques ex vivo . Integral depolarization factor (IDF) and effective birefringence coefficient (Δ n ) were proposed as parameters for quantitative characterization of the CP OCT images. Results. Calculation of the IDF and Δ n in the local region of interest (intima/fibrous cap ...

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    4. The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy

      The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy

      The aim of the investigation was to evaluate the possibilities for using cross-polarization optical coherence tomography (CP OCT) to monitor the effectiveness of treatment of cancer of the mouth cavity and of the cervix uteri after photodynamic therapy (PDT) and radiation therapy (RT). Materials and Methods. The CP OCT investigation was performed with an OCT-1300U (Institute of Applied Physics of the Russian Academy of Sciences, LLC “Biomedtech”, Russia) tomograph. The monitoring of the two types of treatment was performed after different periods of exposure: for RT of the mouth cavity cancer — once every 2–3 days throughout the whole course ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Institute of Applied Physics
    2. (4 articles) Nizhny Novgorod State Medical Academy
    3. (4 articles) Natalia D. Gladkova
    4. (3 articles) Elena B. Kiseleva
    5. (2 articles) University of Toronto
    6. (2 articles) Mikhail Y. Kirillin
    7. (2 articles) Felix I. Feldchtein
    8. (2 articles) Elena V. Zagaynova
    9. (2 articles) I. Alex Vitkin
    10. (1 articles) Natalia M. Shakhova
    11. (1 articles) Fujian Normal University
    12. (1 articles) UCLA
    13. (1 articles) Saarland University
    14. (1 articles) Srinivas R. Sadda
    15. (1 articles) Yuhua Zhang
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    Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study Accuracy of optical coherence tomography imaging in assessing aneurysmal remnants after flow diversion Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography? CD4+/CD8+ ratio positively correlates with coronary plaque instability in unstable angina pectoris patients but fails to predict major adverse cardiovascular events Optical coherent tomography to evaluate the degree of inflammation in a mouse model of colitis Circumpapillary collateral vessel development in iatrogenic central retinal artery occlusion observed using OCT angiography Deep learning with 4D spatio-temporal data representations for OCT-based force estimation Assessment of retinal vascular network in amnestic mild cognitive impairment by optical coherence tomography angiography