1. Articles from Alexander I. Omelchenko

    1-3 of 3
    1. Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape

      Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape

      We describe the use of elastographic processing in phase-sensitive optical coherence tomography (OCT) for visualizing dynamics of strain and tissue-shape changes during laser-induced photothermal corneal reshaping, for applications in the emerging field of non-destructive and non-ablative (non-LASIK) laser vision correction. The proposed phase-processing approach based on fairly sparse data acquisition enabled rapid data processing and near-real-time visualization of dynamic strains. The approach avoids conventional phase unwrapping, yet allows for mapping strains even for significantly supra-wavelength inter-frame displacements of scatterers accompanied by multiple phase-wrapping. These developments bode well for real-time feedback systems for controlling the dynamics of corneal deformation with 10 ...

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    2. Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping

      Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping

      Phase-sensitive optical coherence tomography (OCT) is used for visualizing dynamic and cumulative strains and corneashape changes during laser-produced tissue heating. Such non-destructive (non-ablative) cornea reshaping can be used as a basis of emerging technologies of laser vision correction. In experiments with cartilaginous samples, polyacrilamide phantoms and excised rabbit eyes we demonstrate ability of the developed OCT system to simultaneously characterize transient and cumulated strain distributions, surface displacements, scattering tissue properties and possibility of temperature estimation via thermal-expansion measurements. The proposed approach can be implemented in perspective real-time OCT systems for ensuring safety of new methods of laser reshaping of cornea.

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    3. Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping

      Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping

      In the context of the development of emerging laser-assisted thermo-mechanical technologies for non-destructive reshaping of avascular collagenous tissues (cartilages and cornea), we report the first application of phase-sensitive optical coherence tomography (OCT) for visualizing transient strains involving supra-wavelength inter-frame displacements of scatterers. Usually phase-sensitive OCT assumes the visualization of sub-pixel and even sub-wavelength displacements of scatterers and fairly small strains (say, <10 −3 ), which conventionally implies the necessity of averaging for enhancing the effective signal-to-noise ratio and, correspondingly, the application of small-amplitude actuators producing periodic deformations. The original approach used here allows for direct estimation of elevated strains ~10 −2 ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Grigory V. Gelikonov
    2. (2 articles) Nizhny Novgorod State Medical Academy
    3. (2 articles) Institute of Applied Physics
    4. (2 articles) University of Toronto
    5. (2 articles) I. Alex Vitkin
    6. (1 articles) Institute of Applied Physics
    7. (1 articles) Nicolaus Copernicus University
    8. (1 articles) Nizhny Novgorod State Medical Academy
    9. (1 articles) National University of Ireland, Galway
    10. (1 articles) University of Auckland
    11. (1 articles) Frederique Vanholsbeeck
    12. (1 articles) Natalia D. Gladkova
    13. (1 articles) Martin J. Leahy
    14. (1 articles) Optovue
    15. (1 articles) Optovue RTVue-100
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