1. Articles from Lele Cui

    1-14 of 14
    1. Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography

      Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography

      Purpose . To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods . Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear. The conjunctival overlap was ranked as the percentage of the edge covered by the conjunctiva. The frequency of occurrence for visualized peripheral ...

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    2. Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography

      Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography

      Objectives . To evaluate the centration and movement of soft contact lenses and to verify the repeatability of two repeated measurements of the lens centration and movement using ultra-long scan depth optical coherence tomography (UL-OCT). Methods . A 1-day Acuvue® Define™ lens was tested on both eyes of 10 subjects (5 males and 5 females; mean age, 31.6 years). The centration and blink-induced movement of the contact lens were measured using UL-OCT at 5 min and 30 min after insertion. The measurements were repeated once at each checkpoint. Results . Good repeatability was found in the lens centration and movement between the ...

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    3. Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment

      Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment

      Purpose: This study was designed to determine the ability of ultra-high-resolution optical coherence tomography (UHR-OCT) to monitor tear meniscus volume after dry eye treatment with Restasis® (0.05% cyclosporine). Methods: UHR-OCT was used to image the upper and lower tear menisci (height and volume) in 14 consecutive dry eye patients at baseline. The treatment group was initiated on daily Restasis and measurements were repeated at 1 and 2 months while on treatment. All measurements were performed immediately after a blink. Results: The baseline tear meniscus volumes were 0.40 ± 0.19 µL (upper) and 0.43 ± 0.18 µL (lower ...

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    4. Visualization of the Precorneal Tear Film Using Ultrahigh Resolution Optical Coherence Tomography in Dry Eye

      Visualization of the Precorneal Tear Film Using Ultrahigh Resolution Optical Coherence Tomography in Dry Eye

      Purpose: To visualize the precorneal tear film (PCTF) in dry eye patients using ultrahigh resolution optical coherence tomography (UHR-OCT). Methods: A custom-built UHR-OCT with ultrahigh resolution (~3 [mu]m) was used to image the PCTF at the vertical meridian. Eighteen right eyes of 18 previously diagnosed dry eye patients (9 men and 9 women, age, 47.8+/-20.7 years) with aqueous tear deficiency were studied. Images were taken during normal and delayed blinking. The visualized PCTF was measured directly. An indirect calculation was used to obtain the thickness in cases where the PCTF could not be visualized. Results: During ...

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    5. Vertical and Horizontal Corneal Epithelial Thickness Profiles Determined by Ultrahigh Resolution Optical Coherence Tomography

      Vertical and Horizontal Corneal Epithelial Thickness Profiles Determined by Ultrahigh Resolution Optical Coherence Tomography

      Purpose: To measure vertical and horizontal thickness profiles of the central and peripheral corneal epithelium and determine if daytime changes occur. Methods: Forty eyes of 20 normal subjects were imaged by ultrahigh resolution spectral domain optical coherence tomography to profile the corneal epithelial thickness from the edge of Bowman layer to the central cornea across the vertical and horizontal meridians. Measurements were made at 10:00 AM and again at 6 and 8 hours later. Results: The baseline vertical meridional epithelial thickness was thinnest, 42.9 +/- 4.1 [mu]m, at the edge of Bowman layer in the superior region ...

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    6. Micrometer-Scale Contact Lens Movements Imaged by Ultrahigh-resolution Optical Coherence Tomography

      Micrometer-Scale Contact Lens Movements Imaged by Ultrahigh-resolution Optical Coherence Tomography

      Purpose To dynamically evaluate contact lens movement and ocular surface shape using ultrahigh-resolution and ultralong-scan-depth optical coherence tomography (OCT). Design Clinical research study of a laboratory technique. Methods Four different types of soft contact lenses were tested on the left eye of 10 subjects (6 male and 4 female). Lens edges at primary gaze and temporal and nasal gazes were imaged by ultrahigh-resolution OCT. Excursion lag was obtained as the distance between the lens edge at primary gaze and immediately after the eye was quickly turned either nasally or temporally. The inferior lens edges were imaged continuously to track vertical ...

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    7. Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

      Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

      Developments in optical coherence tomography (OCT) have expanded its clinical applications for ultra-high resolution imaging of the anterior segment of the human eye. This review presents the latest advances for imaging the anterior segment of the eye using ultra-high resolution OCT (UHR-OCT). Unique applications of UHR-OCT technology in clinical and basic scientific laboratory research are discussed and a summary of the results is provided. The authors focused on the use of UHR-OCT for imaging of tear dynamics, contact lens interactions with the corneal surface, and in vivo histological diagnosis of disorders of the cornea, as well as the future direction ...

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    8. Age-Related Changes in Tear Menisci Imaged by Optical Coherence Tomography

      Age-Related Changes in Tear Menisci Imaged by Optical Coherence Tomography
      Purpose. To determine age-related changes of tear menisci in healthy subjects and to compare tear variables between age-matched normals and dry eye subjects. Methods. Anterior segment optical coherence tomography was used to measure upper and lower tear menisci in healthy subjects (n = 197, 8-83 years) and in age-matched dry eye patients (n = 38, 19-72 years). Measured tear variables included the height and area of the tear meniscus. Tear meniscus volumes were calculated based on the cross-sectional areas of the tear menisci and the eyelid lengths. The age-related decrease rates of the tear menisci were also calculated. Results. There were significant ...
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    9. Extended scan depth optical coherence tomography for evaluating ocular surface shape

      Extended scan depth optical coherence tomography for evaluating ocular surface shape

      Spectral domain optical coherence tomography (SD-OCT) with extended scan depth makes it possible for quantitative measurement of the entire ocular surface shape. We proposed a novel method for ocular surface shape measurement using a custom-built anterior segment SD-OCT, which will serve on the contact lens fitting. A crosshair alignment system was applied to reduce the misalignment and tilting of the eye. An algorithm was developed to automatically segment the ocular surface. We also described the correction of the image distortion from the segmented dataset induced by the nontelecentric scanning system and tested the accuracy and repeatability. The results showed high ...

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    10. Characterization of soft contact lens edge fitting using ultra-high resolution and ultra-long scan depth optical coherence tomography

      Characterization of soft contact lens edge fitting using ultra-high resolution and ultra-long scan depth optical coherence tomography
      Objective: To characterize the edge fitting of soft contact lenses using ultra-high resolution (UHR-OCT) and ultra-long scan depth (UL-OCT) optical coherence tomography. Methods: A total of 20 participants (11 males, 9 females, mean age 32.3 years) were recruited. Four different types of soft contact lenses were randomly fitted to both eyes of each subject on two separate visits. After 30 minutes, the horizontal meridians of the corneal center, mid-periphery, and limbus were imaged by UHR-OCT. UL-OCT imaged each lens in vitro and the ocular surface of a physical model eye. Results: Angle-edged lenses had significantly less conjunctival buildup than ...
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    11. Detection of Magnetic Particles in Live DBA/2J Mouse Eyes Using Magnetomotive Optical Coherence Tomography

      Detection of Magnetic Particles in Live DBA/2J Mouse Eyes Using Magnetomotive Optical Coherence Tomography

      Objectives: To demonstrate in vivo molecular imaging of the eye using spectral-domain magnetomotive optical coherence tomography (MMOCT).Methods: A custom-built, high-speed, and high-resolution MMOCT was developed for imaging magnetic particle-coupled molecules in living mouse eyes by applying an external dynamic magnetic field gradient during optical coherence tomography (OCT) scanning. The magnetomotive signals were tested in vitro by scanning magnetic beads embedded within an agarose gel (1.5%) and in vivo in the anterior segment of a mouse eye.Results: Cross-sectional OCT images of the gel and the anterior segment of the eye were acquired by regular OCT structural scanning. Magnetomotive ...

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    12. Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography

      Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography
      Purpose: To investigate the in vivo sutureless vitrectomy incision architecture using optical coherence tomography (OCT) in the immediate postoperative period.Design: Prospective, observational case series.Participants: Thirty-five patients underwent 3-port pars plana vitrectomy using 23-gauge instrumentation combined with 25-gauge infusion at the Wenzhou Eye Hospital.Methods: All incisions were evaluated using the Carl Zeiss Visante (Dublin, CA) anterior segment OCT imaging system within 5 hours postoperatively.Main Outcome Measurements: Wound architecture (e.g., the length and angle of the incision, presence of gaping), and presence of ciliochoroidal detachment and vitreous incarceration. Seidel test and intraocular pressure (IOP) measurements were performed ...
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    13. Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography

      Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography
      Purpose: To investigate the in vivo sutureless vitrectomy incision architecture using optical coherence tomography (OCT) in the immediate postoperative period.Design: Prospective, observational case series.Participants: Thirty-five patients underwent 3-port pars plana vitrectomy using 23-gauge instrumentation combined with 25-gauge infusion at the Wenzhou Eye Hospital.Methods: All incisions were evaluated using the Carl Zeiss Visante (Dublin, CA) anterior segment OCT imaging system within 5 hours postoperatively.Main Outcome Measures: Wound architecture (e.g., the length and angle of the incision, presence of gaping), and presence of ciliochoroidal detachment and vitreous incarceration. Seidel test and intraocular pressure (IOP) measurements were performed ...
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    14. Lower volumes of tear menisci are associated with dry eye symptoms in contact lens wearers

      Purpose: To investigate tear meniscus volumes during short-term wear by soft contact lens (SCL) wearers with dryness symptoms. Methods: Three groups of 20 subjects were recruited. Group 1 consisted of SCL wearers with self-reported dryness. Group 2 consisted of asymptomatic wearers. Group 3 was composed of asymptomatic non-lens wearers. Contact lenses were fitted on each eye, and both upper and lower tear menisci were imaged before lens insertion, immediately afterwards, and 30 min later, using optical coherence tomography. Custom software was used to yield the tear meniscus area and then the volumes were calculated based on eyelid length. Repeatability was ...
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    1-14 of 14
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    1. (12 articles) Meixiao Shen
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    Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography Characterization of soft contact lens edge fitting using ultra-high resolution and ultra-long scan depth optical coherence tomography Extended scan depth optical coherence tomography for evaluating ocular surface shape Age-Related Changes in Tear Menisci Imaged by Optical Coherence Tomography Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye Micrometer-Scale Contact Lens Movements Imaged by Ultrahigh-resolution Optical Coherence Tomography Vertical and Horizontal Corneal Epithelial Thickness Profiles Determined by Ultrahigh Resolution Optical Coherence Tomography Visualization of the Precorneal Tear Film Using Ultrahigh Resolution Optical Coherence Tomography in Dry Eye Vitreous Seeding in Retinocytoma: Importance of Optical Coherence Tomography Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study Visualizing and quantifying cutaneous microvascular reactivity in humans using optical coherence tomography: Impaired dilator function in diabetes