1. Articles from Yi-Ting Hsieh

    1-11 of 11
    1. Quantitative analysis of branching neovascular networks in polypoidal choroidal vasculopathy by optical coherence tomography angiography after photodynamic therapy and anti-vascular endothelial growth factor combination therapy

      Quantitative analysis of branching neovascular networks in polypoidal choroidal vasculopathy by optical coherence tomography angiography after photodynamic therapy and anti-vascular endothelial growth factor combination therapy

      Purpose: To study serial changes in branching neovascular networks (BNN) by using optical coherence tomography angiography (OCTA) in patients with polypoidal choroidal vasculopathy (PCV) who underwent combined photodynamic therapy (PDT) and anti-vascular endothelial growth factor (anti-VEGF) therapy. Methods: In this retrospective study of 30 PCV patients who underwent combined therapy, OCTA images obtained at baseline and 1, 3, and 6 months after treatment were collected. The vessel area, vessel percentage area, average vessel length, and presence of polypoidal lesions on OCTA images as well as best-corrected visual acuity (BCVA), central retinal thickness (CRT), and central choroidal thickness (CCT) were recorded ...

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    2. Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Purpose To develop deep learning models for identification of sex and age from macular optical coherence tomography (OCT), and to analyze the features for differentiation of sex and age. Design Algorithm development using database of macular OCT. Setting One eye center in Taiwan. Study Population 6147 sets of macular optical coherence tomography (OCT) images from the healthy eyes of 3134 persons. Main Outcome Measures Deep learning based algorithms were used to develop models for identification of sex and age, and 10-fold cross-validation was applied. Gradient-weighted class activation mapping (Grad-CAM) was used for feature analysis. Results The accuracy for sex prediction ...

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    3. Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

      Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

      This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). In total, we reviewed 70 eyes with PCV followed up for > 12 months. OCTA, ICGA and FA images were obtained at baseline and post-treatments. BVN was assessed using OCTA and divided into three types by a previously described BVN classification: type 1 (trunk), type 2 (glomeruli), and type 3 (stick). At baseline, type 1 BVN ...

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    4. Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Purpose: To investigate choroidal neovascularization (CNV) activity after anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD) by optical coherence tomography angiography (OCTA) and to determine whether combined qualitative and quantitative biomarkers can achieve high predictive accuracy to guide treatment decisions. Methods: Patients diagnosed with type 1 or type 2 CNV via multimodal imaging who had received anti-VEGF treatmentwere retrospectively reviewed. Qualitative and quantitative CNV responses on OCTA after serial injections were analyzed, and the assessment was correlated with their structural OCT scans. The enrolled eyes were divided into two groups: eyes with exudative signs ...

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    5. Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems

      Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems

      Three-dimensional (3D) configuration of in vitro cultivated cells has been recognised as a valuable tool in developing stem cell and cancer cell therapy. However, currently available imaging approaches for live cells have drawbacks, including unsatisfactory resolution, lack of cross-sectional and 3D images, and poor penetration of multi-layered cell products, especially when cells are cultivated on semitransparent carriers. Herein, we report a prototype of a full-field optical coherence tomography (FF-OCT) system with isotropic submicron spatial resolution in en face and cross-sectional views that provides a label-free, non-invasive platform with high-resolution 3D imaging. We validated the imaging power of this prototype by ...

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    6. Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Purpose : To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy. Methods : A deep-learning convolutional neural network (CNN) architecture, VGG16, was employed for this study. A transfer learning process was implemented to retrain the CNN for robust OCTA classification. One dataset, consisting of images of 32 healthy eyes, 75 eyes with diabetic retinopathy (DR), and 24 eyes with diabetes but no DR (NoDR), was used for training and cross-validation. A second dataset consisting of 20 NoDR and 26 DR eyes was used for external validation. To demonstrate the feasibility of using artificial ...

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    7. Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema

      Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema

      Purpose To explore the impact of macular ischaemia on vision in diabetic macular oedema (DMO) by analysing the correlations between visual acuity and macular microvascular parameters using optical coherence tomography angiography (OCTA). Methods OCTA was performed in 81 eyes of 48 patients with DMO, and 3 × 3-mm 2 en face OCTA images of the superficial capillary plexus and deep capillary plexus in the central macula were retrospectively collected. Microvascular parameters including the number of microaneurysms, area of foveal avascular zone (FAZ), acircularity index of FAZ, vessel density, skeleton density, vessel density index and fractal dimension were measured. Central retinal thickness ...

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    8. Macular Hole Formation Secondary to Rhegmatogenous Retinal Detachment Demonstrated With Optical Coherence Tomography

      Macular Hole Formation Secondary to Rhegmatogenous Retinal Detachment Demonstrated With Optical Coherence Tomography

      The author presents two cases of macular hole (MH) retinal detachment in non-myopic eyes for which optical coherence tomography demonstrated a detached macula and a nearly full-thickness MH with only the elongated outer segments connecting at the fovea. Such images have rarely been observed in cases of MH retinal detachment in highly myopic eyes or secondary to vitreomacular traction. This implies that MH may form secondary to a macula-off rhegmatogenous retinal detachment, as it may result from the pushing forces of the subretinal fluid involving the macula.

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    9. Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study

      Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study

      This study evaluated the characteristic changes in optical coherence tomography (OCT) biomarkers in neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor drugs and their relationship with visual outcomes at 1-year follow-up in a real-world setting. We retrospectively reviewed the medical records of 126 eyes with nAMD treated with either intravitreal ranibizumab or aflibercept, including ophthalmologic examinations and spectral-domain OCT at baseline and months 3, 6, and 12 after first injection. Treatment response of intraretinal cysts (IRCs), subretinal fluid (SRF), and pigment epithelial detachment (PED), and the correlation between best-corrected visual acuity (BCVA) changes and these OCT biomarkers ...

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    10. Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography

      Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography

      This study analyze the morphological characteristics of branching vascular networks (BVN) in polypoidal choroidal vasculopathy (PCV) using optical coherence tomography angiography (OCTA), and correlate imaging characteristics with clinical presentations. We presented a retrospective observational case series for fifty cases of PCV confirmed by indocyanine green angiography. Macular OCTA were done by the AngioVue. The PCV cases were classified by distinct morphologic patterns of BVN by two retina specialists and clinical features were analyzed. The sensitivity of polyp detection by OCTA was 86% after manual segmentation and that of BVN was 90%. Three distinct morphologic patterns of BVN were identified. (1 ...

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    11. Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt

      Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt

      Abstract: Using spectral-domain optical coherence tomography (OCT) to observe the morphology and epithelial thickness (ET) of the palisades of Vogt (POV), and to evaluate the role of age and region on these structures. One hundred twelve eyes of 112 healthy subjects were enrolled and divided into 4 groups: A (0–19), B (20–39), C (40–59), and D (≥60 years old). RTvue-100 OCT was applied on the cornea and the limbus. The morphology of the subepithelial stroma underneath the epithelium of POV was classified into typical and atypical types. Maximum ET of POV was measured manually from OCT images ...

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    1-11 of 11
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    Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study Macular Hole Formation Secondary to Rhegmatogenous Retinal Detachment Demonstrated With Optical Coherence Tomography Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning