1. Articles from Zahra Nafar

    1-3 of 3
    1. Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging

      Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging

      Lipofuscin in the retinal pigment epithelium (RPE) is the major source of fundus autofluorescence (FAF). A technical challenge to accurately quantify the FAF intensities, thus the lipofuscin concentration, is to compensate the light attenuation of RPE melanin. We developed the VIS-OCT-FAF technology to accomplish optical coherence tomography (OCT) and FAF simultaneously with a single broadband visible light source. We demonstrated that light attenuation by RPE melanin can be assessed and corrected using the depth-resolved OCT signals. FAF images from albino and pigmented rats showed that without compensation, FAF signals from pigmented rats are lower than that from albinos. After compensation ...

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    2. Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Fundus autofluorescence (FAF) imaging is commonly used in ophthalmic clinics for diagnosis and monitoring of retinal diseases. Lipofuscin in the retinal pigment epithelium (RPE), with A2E as its most abundant component and a visual cycle by-product, is the major fluorophore of FAF. Lipofuscin accumulates with age and is implicated in degenerative retinal diseases. The amount of lipofuscin in RPE can be assessed by quantitative measurement of FAF. However, the currently available FAF imaging technologies are not capable of quantifying the absolute intensity of FAF, which is essential for comparing images from different individuals, and from the same individual over time ...

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    3. Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification

      Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification

      We developed a spectral-domain visible-light optical coherence tomography (VIS-OCT) based multimodal imaging technique which can accomplish simultaneous OCT and fluorescence imaging with a single broadband light source. Phantom experiments showed that by using the simultaneously acquired OCT images as a reference, the effect of light attenuation on the intensity of the fluorescent images by materials in front of the fluorescent target can be compensated. This capability of the multimodal imaging technique is of high importance for achieving quantification of the true intensities of autofluorescence (AF) imaging of the retina. We applied the technique in retinal imaging including AF imaging of ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Florida International University
    2. (3 articles) Shuliang Jiao
    3. (2 articles) University of Miami
    4. (1 articles) Duke University
    5. (1 articles) Minshan Jiang
    6. (1 articles) Harvard University
    7. (1 articles) Massachusetts General Hospital
    8. (1 articles) University of North Carolina
    9. (1 articles) Baylor College of Medicine
    10. (1 articles) Masamichi Takano
    11. (1 articles) Joel S. Schuman
    12. (1 articles) Ik-Kyung Jang
    13. (1 articles) Yoshiyasu Minami
    14. (1 articles) Donald L. Budenz
    15. (1 articles) Gadi Wollstein
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