1. Articles from Takahiko Suzuki

    1-24 of 27 1 2 »
    1. In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation

      In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation

      Background The histopathological validation of optical coherence tomography (OCT) in visualizing atherosclerotic plaques has been reported only in ex vivo studies. We sought to evaluate the accuracy of OCT in tissue characterization in vivo . Methods and results A total of 25 patients with stable angina pectoris who underwent directional coronary atherectomy (DCA) were included in the investigation, whereby OCT was performed before and after a single debulking. The debulked region was determined on OCT and classified into fibrous tissue, lipid, calcification, thrombus, and macrophage accumulation, which were compared with histology. Changes in OCT signal intensity in the deeper intimal region ...

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    2. Angiographical Changes Induced by Tiny Coronary Fistula

      Angiographical Changes Induced by Tiny Coronary Fistula

      An 82-year-old female presented with angina pectoris due to mid-right coronary artery (RCA) stenosis. Percutaneous coronary intervention (PCI) was performed with optical coherence tomography (OCT). When OCT was performed with manual coronary flushing to obtain a clearer image, the contrast media seemed to extravasate from the coronary artery, resembling a coronary perforation; however, the patient did not have any chest pain and her vital signs were stable. Coronary angiography (CAG) performed immediately after the finding showed no abnormalities and the final CAG did not show any abnormalities. Coronary computed tomography angiography after PCI revealed a micro-fistula from the RCA to ...

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    3. Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Although lipid lowering therapy by statin and ezetimibe has been reported to provide greater reduction in low-density lipoprotein cholesterol (LDL-C) levels than statin monotherapy, the effect of supplemental therapy on plaque stabilization is yet to be fully elucidated. Cap thickness of fibroatheroma evaluated by Optical coherence tomography (OCT) is a major determinant of vulnerable plaque. The primary objective of this study is to evaluate the effect of ezetimibe in addition to fluvastatin on progression of coronary atherosclerotic plaque evaluated by OCT. Sixty-three angina pectoris patients with intermediate, non-culprit, lipid-rich plaque lesions evaluated by OCT were enrolled. The patients were divided ...

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    4. OCT Compared With IVUS in a Coronary Lesion Assessment The OPUS-CLASS Study

      OCT Compared With IVUS in a Coronary Lesion Assessment The OPUS-CLASS Study

      The aim of this study was to investigate the reliability of frequency domain optical coherence tomography (FD-OCT) for coronary measurements compared with quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS). Background Accurate luminal measurement is expected in FD-OCT because this technology offers high resolution and excellent contrast between lumen and vessel wall. Methods In 5 medical centers, 100 patients with coronary artery disease were prospectively studied by using angiography, FD-OCT, and IVUS. In addition, 5 phantom models of known lumen dimensions (lumen diameter 3.08 mm; lumen area 7.45 mm 2 ) were examined using FD-OCT and IVUS. Quantitative image ...

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    5. Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography

      Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography

      Objectives The aim of this study was to evaluate the relationship between cholesterol metabolism and coronary plaque vulnerability. Background Cholesterol homeostasis, defined as the balance between absorption and synthesis, influences the progression of coronary atherosclerosis. Methods Consecutive stable angina pectoris patients (N = 80) not receiving any lipid-lowering therapy were divided into 2 groups based on the presence of in vivo thin cap fibroatheroma (TCFA) in de novo target vessels assessed by the combined use of virtual histology intravascular ultrasound and optical coherence tomography. Results Patients with in vivo TCFA (n = 42) showed a higher campesterol-to-lathosterol ratio (3.36 [interquartile range ...

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    6. Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study

      Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study

      Aims Restenosis of drug-eluting stents (DESs) might be different from that of bare metal stent restenosis in diverse ways including mechanisms and time course; however, these have not been fully examined. To gain insight into the mechanisms and time course of DES restenosis, we evaluated the characteristics of restenotic lesions of first generation DES using optical coherence tomography (OCT). Methods and results We compared the morphological characteristics of early in-stent restenosis (<1 year: E-ISR, n = 43), late ISR (1–3 years: L-ISR, n = 22), and very late ISR (>3 years: VL-ISR, n = 21). OCT qualitative restenotic tissue analysis included the ...

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    7. Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance"

      Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance"

      We appreciate the valuable comments by Garcia-Garcia et al regarding our article.1 We agree with the comments on our limitations about study design especially with regard to criteria of the procedure. First, the efficacy of distal protection devices in native coronary arteries is still controversial, and criteria regarding usage of this device are not defined yet. However, we believe this device could be helpful for prevention of distal embolus in certain cases as we have sometimes experienced, and optical frequency-domain imaging (OFDI) is helpful to predict such cases. Making use of the criteria of this study, distal protection was ...

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    8. Serial optical coherence tomography imaging of the “black-hole” phenomenon by intravascular ultrasound following sirolimus-eluting stent implantation

      Serial optical coherence tomography imaging of the “black-hole” phenomenon by intravascular ultrasound following sirolimus-eluting stent implantation

      A 60-year-old man underwent sirolimus-eluting stent (SES) implantatoni.  At two months, intravascular ultrasound (IVUS) images showed homogenous echolucent appearance within the stent, recognized as a"black-hole" phenomeon.  Optical coherence tomography (OCT) images of the correspoinding segment demonstrated a layered structure composed of think inner layers with high-intensity signals and outer layers with low-intensity signals.

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    9. Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance

      Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance

      Background—Frequency-domain optical coherence tomography (FD-OCT) is a novel, high resolution intravascular imaging modality. Intravascular ultrasound (IVUS) is a widely used conventional imaging modality for achieving optimal stent deployment. The aim of this study was to evaluate the impact of FD-OCT guidance for coronary stent implantation compared with IVUS guidance. Methods and Results—A total of 70 patients with de novo coronary artery lesions and either unstable or stable angina pectoris were enrolled in this randomized study (optical coherence tomography [OCT] group: n=35, IVUS group: n=35). In the OCT group, stent implantation was performed under FD-OCT guidance alone ...

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    10. The role of optical coherence tomography in coronary intervention

      The role of optical coherence tomography in coronary intervention

      Optical coherence tomography (OCT) is an optical analog of intravascular ultrasound (IVUS) that can be used to examine the coronary arteries and has 10-fold higher resolution than IVUS. Based on polarization properties, OCT can differentiate tissue characteristics (fibrous, calcified, or lipid-rich plaque) and identify thin-cap fibroatheroma. Because of the strong attenuation of light by blood, OCT systems required the removal of blood during OCT examinations. A recently developed frequency-domain OCT system has a faster frame rate and pullback speed, making the OCT procedure more user-friendly and not requiring proximal balloon occlusion. During percutaneous coronary intervention (PCI), OCT can provide detailed ...

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    11. Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study - Corrected Proof

      Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study - Corrected Proof

      Background Conflicting data have been reported about the association between plaque composition and remodelling index (RI). The aim of this study is to evaluate the relationship between plaque morphology obtained by optical coherence tomography (OCT) and arterial remodelling. Methods and results OCT and intravascular ultrasound imaging pull back was performed at corresponding sites on 94 lesions in 47 patients. OCT plaque characteristics for lipid content, fibrous cap thickness, thin-cap fibroatheroma (TCFA), plaque rupture, thrombus, calcification and erosion were derived using validated criteria. Compared with intermediate/negative remodelling (RI<1.0), positive remodelling (RI>1.0) was associated with presence of higher lipid pool (2.86 ...

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    12. The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis

      The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis

      Aims Epicardial fat volume (EFV) has been implicated in coronary artery disease. Relationship between EFV and coronary plaque vulnerability has not been elucidated. The aim of this study was to investigate the association of EFV with coronary plaque vulnerability by using optical coherence tomography (OCT). Methods and results We enrolled 117 patients who underwent multislice computed tomography (MSCT) and OCT. EFV was quantified on MSCT. Patients were categorized according to tertiles of EFV: low tertile, EFV 3 ; mid-tertile, 104.1 cm 3 ≤ EFV ≤ 130.7 cm 3 ; high tertile, EFV > 130.7 cm 3 . A total of 180 vessels and ...

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    13. Difference of Tissue Characteristics Between Early and Very Late Restenosis Lesions After Bare-Metal Stent Implantation: An Optical Coherence Tomography Study

      Difference of Tissue Characteristics Between Early and Very Late Restenosis Lesions After Bare-Metal Stent Implantation: An Optical Coherence Tomography Study
      Background—Although in-stent restenosis (ISR) after bare-metal stent (BMS) implantation peaks in the early phase, very late (VL) ISR occasionally is observed beyond a few years after BMS implantation. To date, this mechanism has not been fully clarified. Methods and Results—We compared the morphological characteristics of VL-ISR (>5 years, without restenosis within the first year) (n=43) to those of early (E) ISR (within the first year) (n=39) using optical coherence tomography (OCT). Qualitative restenotic tissue analysis included assessment of tissue structure (homogeneous or heterogeneous), presence of microvessels, disrupted intima with cavity, and intraluminal material and was performed ...
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    14. Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography

      Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography
      The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence tomography. Based on optical coherence tomographic findings, lesions were classified as thin-capped fibroatheroma (TCFA; n = 37) and non-TCFA (n = 85). Mean computed tomographic density value of the lesion was lower and remodeling index was larger in the TCFA group (44.9 ± 19.2 vs 78.7 ± 25.0 HU, p
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    15. In-vivo detection of the frequency and distribution of thin-cap fibroatheroma and ruptured plaques in patients with coronary artery disease: an optical coherence tomographic study

      In-vivo detection of the frequency and distribution of thin-cap fibroatheroma and ruptured plaques in patients with coronary artery disease: an optical coherence tomographic study
      Objectives: The purpose of this study was to assess the prevalence and to quantify the thin-cap fibroatheroma (TCFA) and ruptured plaques in patients with coronary artery disease using optical coherence tomography (OCT). Background: TCFA lesions are the most prevalent precursors of plaque rupture, and are responsible for acute coronary syndromes (ACS). There are limited data regarding the frequency and distribution of TCFA in diseased coronary arteries. Methods: Coronary artery OCT was performed in 78 vessels in 47 patients, with stable angina (SA) or ACS. OCT plaque characteristics were derived using criteria that had been validated earlier. TCFA was defined as ...
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    16. Different Patterns of Vascular Response Between Patients With or Without Diabetes Mellitus After Drug-Eluting Stent Implantation: Optical Coherence Tomographic Analysis

      Different Patterns of Vascular Response Between Patients With or Without Diabetes Mellitus After Drug-Eluting Stent Implantation: Optical Coherence Tomographic Analysis
      Objectives We performed this study to investigate with optical coherence tomography (OCT) the vascular response after sirolimus-eluting stent (SES) implantation between patients with and those without diabetes mellitus (DM). Background The difference in vascular response after SES implantation between patients with and those without DM has not been fully evaluated with OCT. Methods Optical coherence tomography was performed to examine 74 nonrestenotic SES implanted in 63 patients (32 with DM and 31 without DM) at 9 months after SES implantation. For struts showing neointimal coverage, the neointimal thickness on the luminal side of each strut section was measured, and neointimal ...
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    17. Late-Acquired Stent Malapposition after Sirolimus-Eluting Stent Implantation following Acute Coronary Syndrome: Angiographic, IVUS, OCT and Coronary Angioscopic Observation

      Late-Acquired Stent Malapposition after Sirolimus-Eluting Stent Implantation following Acute Coronary Syndrome: Angiographic, IVUS, OCT and Coronary Angioscopic Observation
      ABSTRACT: Drug-eluting stents (DES) have been shown to significantly reduce the incidence of restenosis and target lesion revascularization in a wide variety of clinical situations. DES have also been shown to significantly reduce neointimal hyperplasia as compared to bare-metal stents. However, the antiproliferative properties of DES also delay vascular healing and have been associated with stent malapposition, hypersensitivity reactions and late stent thrombosis. Stent thrombosis could result in myocardial infarction or death. We describe here a case report of late stent malapposition following sirolimus-eluting stent implantation observed by angiography, intravascular ultrasound, optical coherence tomography and angioscopy. J INVASIVE CARDIOL 2009 ...
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    18. Comparative Analysis of Vascular Responses Following Stent Implantation in the Lesion Wth Acute Coronary Syndrome Between Paclitaxel-Eluting and Bare-Metal Stent Using Optical Coherence Tomography

      Background: Safety and feasibility of drug-eluting stent in the lesion with acute coronary syndrome (ACS) is still controversial. Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality, which is expected to visualize microscopic vascular response to coronary intervention. The purpose of this study is to evaluate the difference of vascular responses following stent implantation in the ACS lesions between paclitaxel-eluting stent (PES) and bare-metal stent (BMS) using OCT. Method: Fifty-eight ACS patients who were treated with either PES or BMS (33PESs and 25 BMSs) underwent OCT at 3 months follow-up, and 38 of them (20PESs and 18BMSs) also had ...
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    19. Comparison of Subsequent Vascular Response in Diabetic Patients Following Coronary Stenting Between Sirolimus- and Paclitaxel-Eluting Stents: Optical Coherence Tomography Analysis

      Comparison of Subsequent Vascular Response in Diabetic Patients Following Coronary Stenting Between Sirolimus- and Paclitaxel-Eluting Stents: Optical Coherence Tomography Analysis
      Background: Diabetes mellitus is one of the major predictors for target lesion revascularization even in drug-eluting stent era. The aim of this study is to evaluate the differences of chronic vascular response in patients with diabetes mellitus (DM) following coronary stenting between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) using optical coherence tomography (OCT). Methods: We examined non-restenotic 60 SESs and 60 PESs were imaged with motorized OCT pull-back system (1 mm/s) at 9-month follow-up and analyzed at interval of 1 mm. Neointimal coverage of stent struts and the incidence of stent malapposition were evaluated. Results: See table. Conclusions ...
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    20. Detection of Vulnerable Plaque by Multislice Computed Tomography, Comparative Study With Optical Coherence Tomography

      Background: Acute coronary syndrome is commonly caused by disruption of vulnerable plaque that is characterized by thin fibrous cap (<65 µm) and large lipid pool. Noninvasive detection of vulnerable plaque using multislice computed tomography (MSCT) could be useful for risk stratification in patients with coronary artery disease. The purpose of this study is to investigate the possibility of MSCT to detect a thin-capped fibroatheroma (TCFA) by comparing the optical coherence tomography (OCT) findings. Methods and results: From January 2008 to March 2009, 77 lesions (19 unstable angina pectoris (uAP) culprit, 19 uAP non-culprit and 39 stable angina pectoris) in 43 ...
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    21. Accuracy and Reproducibility of Stent-Strut Thickness Determined by Optical Coherence Tomography

      Accuracy and Reproducibility of Stent-Strut Thickness Determined by Optical Coherence Tomography
      Background. Optical coherence tomography (OCT) has been increasingly used to evaluate stent apposition following implantation. Since stent struts are visualized as linear structures with strong surface reflection and typical dorsal shadowing, apposition of struts is evaluated by measuring the distance between the strut surface reflection and adjacent vessel surface in consideration of strut thickness. However, there are no data available to validate the measurements of strut thickness by OCT. The aim of this in vitro study is to validate the accuracy of OCT measurement of stent-strut thickness of different commercially available stents in evaluating stent apposition. Methods. We performed the ...
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    22. Detection of atherosclerotic progression with rupture of degenerated in-stent intima five years after bare-metal stent implantation using optical coherence tomography

      Detection of atherosclerotic progression with rupture of degenerated in-stent intima five years after bare-metal stent implantation using optical coherence tomography
      In-stent intimal hyperplasia peaks in the early phase (6–12 months) after bare-metal stent (BMS) implantation. However, late luminal re-narrowing due to atherosclerotic progression of in-stent intima is reported beyond 4 years. We report the optical coherence tomographic findings of a case of late restenosis of BMS 5 years after implantation. Remarkable in-stent intimal growth was observed, demonstrating a heterogeneous appearance including low-intensity areas and accompanied by intimal rupture. These findings were similar to the morphology of ruptured fibroatheroma in the native coronary artery, and suggested that atherosclerotic change in the in-stent intima occurred over the 5 years following BMS ...
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    1-24 of 27 1 2 »
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    1. (27 articles) Toyohashi Heart Center
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    Difference in Neointimal Growth on the Stent Struts Crossing a Side Branch Between Sirolimus-Eluting Stent and Bare-Metal Stent: An Optical Coherence Tomography Analysis Detection of atherosclerotic progression with rupture of degenerated in-stent intima five years after bare-metal stent implantation using optical coherence tomography Accuracy and Reproducibility of Stent-Strut Thickness Determined by Optical Coherence Tomography Late-Acquired Stent Malapposition after Sirolimus-Eluting Stent Implantation following Acute Coronary Syndrome: Angiographic, IVUS, OCT and Coronary Angioscopic Observation Different Patterns of Vascular Response Between Patients With or Without Diabetes Mellitus After Drug-Eluting Stent Implantation: Optical Coherence Tomographic Analysis Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography Serial optical coherence tomography imaging of the “black-hole” phenomenon by intravascular ultrasound following sirolimus-eluting stent implantation OCT Compared With IVUS in a Coronary Lesion Assessment The OPUS-CLASS Study Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies ‘Primum non nocere’ aortic dissection involving ostium of right coronary artery diagnosed by optical coherence tomography Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players Research Scientist for Optical Diagnostic at Carestream Dental