1. Articles from Tetsuo Matsubara

    1-5 of 5
    1. In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation

      In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation

      Background The histopathological validation of optical coherence tomography (OCT) in visualizing atherosclerotic plaques has been reported only in ex vivo studies. We sought to evaluate the accuracy of OCT in tissue characterization in vivo . Methods and results A total of 25 patients with stable angina pectoris who underwent directional coronary atherectomy (DCA) were included in the investigation, whereby OCT was performed before and after a single debulking. The debulked region was determined on OCT and classified into fibrous tissue, lipid, calcification, thrombus, and macrophage accumulation, which were compared with histology. Changes in OCT signal intensity in the deeper intimal region ...

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    2. Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Although lipid lowering therapy by statin and ezetimibe has been reported to provide greater reduction in low-density lipoprotein cholesterol (LDL-C) levels than statin monotherapy, the effect of supplemental therapy on plaque stabilization is yet to be fully elucidated. Cap thickness of fibroatheroma evaluated by Optical coherence tomography (OCT) is a major determinant of vulnerable plaque. The primary objective of this study is to evaluate the effect of ezetimibe in addition to fluvastatin on progression of coronary atherosclerotic plaque evaluated by OCT. Sixty-three angina pectoris patients with intermediate, non-culprit, lipid-rich plaque lesions evaluated by OCT were enrolled. The patients were divided ...

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    3. Difference in Neointimal Growth on the Stent Struts Crossing a Side Branch Between Sirolimus-Eluting Stent and Bare-Metal Stent: An Optical Coherence Tomography Analysis

      Difference in Neointimal Growth on the Stent Struts Crossing a Side Branch Between Sirolimus-Eluting Stent and Bare-Metal Stent: An Optical Coherence Tomography Analysis
      Background: A bifurcation lesion has been demonstrated to be the high risk lesion for late stent thrombosis (LST) following drug-eluting stent implantation, resulting from disturbed laminar blood flow and delayed endothelialization of unapposed stent struts. We examined differences in neointimal growth on the stent struts crossing a side branch between sirolimus-eluting stent (SES) and bare-metal stent (BMS) using optical coherence tomography (OCT).. Methods and Results: Of the 41 stents (34 cases) implanted across side branches, 70 struts of 28 SES and 23 struts of 13 BMS, which crossed over a side branch, were analyzed 9 months after stent implantation using ...
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    4. Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation: evaluation by optical coherence tomography

      Background  Optical coherence tomography (OCT) is a new imaging modality with resolution of approximately 10 μm and can be employed to visualize intracoronary characteristics. Sirolimus-eluting stents (SES) are susceptible to late thrombosis due to delayed re-endothelialization over the stent struts, which may result in acute myocardial infarction or death. This study was designed to evaluate the re-endothelialization and neointimal coverage of SES with OCT 6 months and 12 months after implantat
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Toyohashi Heart Center
    2. (5 articles) Takahiko Suzuki
    3. (4 articles) Mitsuyasu Terashima
    4. (3 articles) Etsuo Tsuchikane
    5. (3 articles) Yoshihisa Kinoshita
    6. (3 articles) Kenya Nasu
    7. (2 articles) Masashi Kimura
    8. (2 articles) Maoto Habara
    9. (2 articles) Massachusetts General Hospital
    10. (2 articles) Harvard University
    11. (2 articles) Guillermo J. Tearney
    12. (1 articles) Tsuyoshi Ito
    13. (1 articles) Osamu Katoh
    14. (1 articles) University of São Paulo
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    Difference in Neointimal Growth on the Stent Struts Crossing a Side Branch Between Sirolimus-Eluting Stent and Bare-Metal Stent: An Optical Coherence Tomography Analysis Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe Red thrombus-like appearance of protruding calcification into the lumen of the coronary artery by optical coherence tomography In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss Miniaturizing medical imaging, sensing technology On-chip tunable photonic delay line Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry Review of methods and applications of attenuation coefficient measurements with optical coherence tomography