1. Articles from Jang Ryul Park

    1-3 of 3
    1. Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling

      Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling

      Changes of retinal blood vessel calibers may reflect various retinal diseases and even several non-retinal diseases. We propose a new method to estimate retinal vessel calibers from 3D optical coherence tomography angiography (OCTA) images based on 3D modeling using superellipsoids. Taking advantage of 3D visualization of the retinal tissue microstructures in vivo provided by OCTA, our method can detect retinal blood vessels precisely, estimate their calibers reliably, and show the relative flow speed visually.

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    2. Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

      Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

      Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the treatment could exacerbate choriocapillary rarefaction, necessitating advanced treatment for fundamental recovery from NV-AMD. In this study, Tie2 activation by angiopoietin-2–binding and Tie2-activating antibody (ABTAA) presents a therapeutic strategy for NV-AMD. Conditional Tie2 deletion impeded choriocapillary maintenance, rendering eyes susceptible to NV-AMD development. Moreover, in a NV-AMD mouse model, ABTAA not only suppressed choroidal neovascularization (CNV) and vascular leakage but ...

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    3. Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography

      Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography

      Purpose : The purpose of this study was to evaluate the performance of optical coherence tomography angiography (OCTA) in visualizing laser-induced choroidal neovascularization (CNV) in the rodent retina. Methods : Choroidal neovascularization was induced via laser photocoagulation in 2 male Brown Norway rats and 2 male C57BL/6 mice. For qualitative comparison, the animals were imaged in vivo with OCTA, indocyanine green angiography (ICGA), and fluorescein angiography (FA), and ex vivo with immunofluorescence confocal microscopy, 14 days post laser photocoagulation without anti-vascular endothelial growth factor (anti-VEGF) intervention. For longitudinal quantitative analysis, CNV was induced in 6 additional male C57BL/6 mice. Three ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Korea Advanced Institute of Science and Technology
    2. (3 articles) Wang Yuhl Oh
    3. (2 articles) WooJhon Choi
    4. (1 articles) Harvard University
    5. (1 articles) Massachusetts General Hospital
    6. (1 articles) Seoul National University
    7. (1 articles) Se Joon Woo
    8. (1 articles) Benjamin J. Vakoc
    9. (1 articles) Kyu Hyung Park
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    Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling KU Leuven leads €6 million research project on heart disease and dementia Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed Retinal Neovascularization–Simulating Retinal Capillary Reperfusion in Branch Retinal Vein Occlusion, Imaged by Wide-Field Optical Coherence Tomography Angiography Conjunctival and Episcleral Blood Flow Restoration After Strabismus Surgery on Swept-Source Optical Coherence Tomography Angiography A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth Special Section Guest Editorial: Advances in Retinal Imaging Optical coherence tomography angiography-derived flow density: a review of the influencing factors Changes in retinal and choriocapillaris density in diabetic patients receiving anti-vascular endothelial growth factor treatment using optical coherence tomography angiography Optical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy