1. Articles from Daniel Jaque

    1-3 of 3
    1. Plasmonic Copper Sulfide Nanoparticles Enable Dark Contrast in Optical Coherence Tomography

      Plasmonic Copper Sulfide Nanoparticles Enable Dark Contrast in Optical Coherence Tomography

      Optical coherence tomography (OCT) is an imaging technique affording noninvasive optical biopsies. Like for other imaging techniques, the use of dedicated contrast agents helps better discerning biological features of interest during the clinical practice. Although bright OCT contrast agents have been developed, no dark counterpart has been proposed yet. Herein, plasmonic copper sulfide nanoparticles as the first OCT dark contrast agents working in the second optical transparency window are reported. These nanoparticles virtually possess no light scattering capabilities at the OCT working wavelength (≈1300 nm); thus, they exclusively absorb the probing light, which in turn results in dark contrast. The ...

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      Mentions: Fernando Alfonso
    2. Gold nanoshells: Contrast agents for cell imaging by cardiovascular optical coherence tomography

      Gold nanoshells: Contrast agents for cell imaging by cardiovascular optical coherence tomography

      Optical coherence tomography (OCT) has gained considerable attention in interventional cardiovascular medicine and is currently used in clinical settings to assess atherosclerotic lesions and to optimize stent placement. Artery imaging at the cellular level constitutes the first step towards cardiovascular molecular imaging, which represents a major advance in the development of personalized noninvasive therapies. In this work, we demonstrate that cardiovascular OCT can be used to detect individual cells suspended in biocompatible fluids. Importantly, the combination of this catheter-based clinical technique with gold nanoshells (GNSs) as intracellular contrast agents led to a substantial enhancement in the backscattered signal produced by ...

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      Mentions: Fernando Alfonso
    3. Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography

      Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography

      The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real-time tracking ...

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      Mentions: Fernando Alfonso
    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Fernando Alfonso
    2. (2 articles) Baylor College of Medicine
    3. (2 articles) Irina V. Larina
    4. (1 articles) Johns Hopkins University
    5. (1 articles) Dalhousie University
    6. (1 articles) Technical University of Munich
    7. (1 articles) University of North Carolina
    8. (1 articles) University of Toronto
    9. (1 articles) Amy L. Oldenburg
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    11. (1 articles) Carl Zeiss Meditec
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    Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography Gold nanoshells: Contrast agents for cell imaging by cardiovascular optical coherence tomography Plasmonic Copper Sulfide Nanoparticles Enable Dark Contrast in Optical Coherence Tomography Cooperative low-rank models for removing stripe noise from OCTA images MS-CAM: Multi-Scale Class Activation Maps for Weakly-supervised Segmentation of Geographic Atrophy Lesions in SD-OCT Images Attention-guided 3D-CNN Framework for Glaucoma Detection and Structural-Functional Association using Volumetric Images Machine Learning Techniques for Ophthalmic Data Processing: A Review Dynamic Imaging of Mouse Embryos and Cardiac Development in Static Culture Effects of axial length on retinal nerve fiber layer and macular ganglion cell-inner plexiform layer measured by spectral-domain OCT Innovative method offers a new way of studying developmental cardiac biomechanics, live in 4-D Plaque mOrphology iMpact on Side Branch Occlusion at oPtical Coherence Tomography Evaluation in Percutaneous Coronary Interventions Full-range space-division multiplexing optical coherence tomography angiography