1. Articles from Mariano Suppa

    1-12 of 12
    1. Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders

      Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders

      Background: The spectrum of pustular skin disorders (PSD) is large and particularly challenging, including inflammatory, infectious and amicrobial diseases. Moreover, although pustules represent the unifying clinical feature, they can be absent or not fully developed in the early stage of the disease. The line-field confocal optical coherence tomography (LC-OCT) is a recently developed imaging technique able to perform a non-invasive, in vivo, examination of the epidermis and upper dermis, reaching very high image resolution and virtual histology. Objectives: We aimed to investigate the potentialities of LC-OCT in the non-invasive differential diagnosis of a series of 11 PSD with different etiology ...

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    2. Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning

      Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning

      Diagnosis based on histopathology for skin cancer detection is today's gold standard and relies on the presence or absence of biomarkers and cellular atypia. However it suffers drawbacks: it requires a strong expertise and is time-consuming. Moreover the notion of atypia or dysplasia of the visible cells used for diagnosis is very subjective, with poor inter-rater agreement reported in the literature. Lastly, histology requires a biopsy which is an invasive procedure and only captures a small sample of the lesion, which is insufficient in the context of large fields of cancerization. Here we demonstrate that the notion of cellular ...

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    3. Line-field confocal optical coherence tomography of actinic keratosis: a case series

      Line-field confocal optical coherence tomography of actinic keratosis: a case series

      Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique that was recently developed, combining high penetration depth (up to 500-µm, approaching that of conventional OCT) with high isotropic resolution [lateral: 1.3 µm; axial: 1.1 µm - similar to that of reflectance confocal microscopy (RCM)]. 1 .

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    4. Line-field confocal optical coherence tomography of sebaceous hyperplasia: a case series

      Line-field confocal optical coherence tomography of sebaceous hyperplasia: a case series

      Line-field confocal optical coherence tomography (LC-OCT) is a newly developed non-invasive imaging technique that combines high penetration depth (500 µm, similar to conventional OCT) with high isotropic resolution (lateral 1.3 µm, axial 1.1 µm, similar to reflectance confocal microscopy [RCM]). 1 Moreover, with its ability to produce images in both vertical and horizontal planes, it enables a tridimensional (3D) analysis of the skin, which can prove very useful for assessing physiological 2 as well as pathological skin.

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    5. Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

      Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

      An optical technique called line-field confocal optical coherence tomography (LC-OCT) is introduced for high-resolution, noninvasive imaging of human skin in vivo . LC-OCT combines the principles of time-domain optical coherence tomography and confocal microscopy with line illumination and detection using a broadband laser and a line-scan camera. LC-OCT measures the echo-time delay and amplitude of light backscattered from cutaneous microstructures through low-coherence interferometry associated with confocal spatial filtering. Multiple A-scans are acquired simultaneously while dynamically adjusting the focus. The resulting cross-sectional B-scan image is produced in real time at 10  frame  /  s. With an isotropic spatial resolution of ∼1  μm, the ...

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      Mentions: Damae Medical
    6. In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography

      In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography

      High-definition optical coherence tomography (HD-OCT) features of basal cell carcinoma (BCC) have recently been defined. We assessed in vivo optical properties (IV-OP) of BCC, by HD-OCT. Moreover their critical values for BCC subtype differentiation were determined. The technique of semi-log plot whereby an exponential function becomes linear has been implemented on HD-OCT signals. The relative attenuation factor ( µ raf ) at different skin layers could be assessed. . IV-OP of superficial BCC with high diagnostic accuracy (DA) and high negative predictive values (NPV) were (i) decreased µ raf in lower part of epidermis and (ii) increased epidermal thickness (E-T). IV-OP of nodular BCC with ...

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    1-12 of 12
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  2. Topics in the News

    1. (1 articles) University of Copenhagen
    2. (1 articles) Damae Medical
    3. (1 articles) Columbia University
    4. (1 articles) University of Rochester
    5. (1 articles) Stanford University
    6. (1 articles) Johns Hopkins University
    7. (1 articles) National University of Singapore
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    In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors Examination of circumscribed palmar hypokeratosis with line-field confocal optical coherence tomography: Dermoscopic, ultrasonographic and histopathologic correlates Kaposi sarcoma of the glans: New findings by line field confocal optical coherence tomography examination Line-field confocal optical coherence tomography of sebaceous hyperplasia: a case series Line-field confocal optical coherence tomography for non-invasive diagnosis of lichenoid dermatoses of the childhood: A case series Line-field confocal optical coherence tomography of actinic keratosis: a case series Line-field confocal optical coherence tomography: a case on the importance of full-lesion examination for basal cell carcinoma Non-invasive imaging of a rare presentation of infantile generalized eruptive histiocytosis with xanthogranuloma-like appearance: dermoscopy, reflectance confocal microscopy, and line-field optical coherence tomography Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea