1. Articles from Suman K. Manna

    1-4 of 4
    1. Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging

      Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging

      It has been recently demonstrated that structures corresponding to the cell bodies of highly transparent cells in the retinal ganglion cell layer could be visualized noninvasively in the living human eye by optical coherence tomography (OCT) via temporal averaging. Inspired by this development, we explored the application of volumetric temporal averaging in mice, which are important models for studying human retinal diseases and therapeutic interventions. A general framework of temporal speckle-averaging (TSA) of OCT and optical coherence tomography angiography (OCTA) is presented and applied to mouse retinal volumetric data. Based on the image analysis, the eyes of mice under anesthesia ...

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    2. Aperture phase modulation with adaptive optics

      Aperture phase modulation with adaptive optics

      Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented deformable mirror (DM) to introduce minor perturbations in the point spread function. This approach creates uncorrelated speckle patterns in a series of images, enabling averaging to suppress speckle noise while ...

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    3. Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography

      Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography

      Speckle is an inevitable consequence of the use of coherent light in optical coherence tomography (OCT), and often acts as noise that obscures micro-structures of biological tissue. We here present a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) in OCT system: by modulating the phase inside the imaging system pupil aperture with a segmented deformable mirror, thus producing minor perturbations in the point spread function (PSF) to create un-correlated speckle pattern between B-scans, and further averaging to wash out the speckle but maintain the structures. It is a well-controlled and universal method which can efficiently ...

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    4. OCT imaging with temporal dispersion induced intense and short coherence laser source

      OCT imaging with temporal dispersion induced intense and short coherence laser source

      Lower coherence length and higher intensity are two indispensable requirements on the light source for high resolution and large penetration depth OCT imaging. While tremendous interest is being paid on engineering various laser sources to enlarge their bandwidth and hence lowering the coherence length, here we demonstrate another approach by employing strong temporal dispersion onto the existing laser source. Cholesteric liquid crystal (CLC) cells with suitable dispersive slope at the edge of 1-D organic photonic band gap have been designed to provide maximum reduction in coherence volume while maintaining the intensity higher than 50%. As an example, the coherence length ...

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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) UC Davis
    2. (3 articles) Robert J. Zawadzki
    3. (2 articles) Simon Fraser University
    4. (2 articles) Oregon Health & Science University
    5. (2 articles) Marinko V. Sarunic
    6. (2 articles) Pengfei Zhang
    7. (2 articles) Yifan Jian
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    OCT imaging with temporal dispersion induced intense and short coherence laser source Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography Aperture phase modulation with adaptive optics Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging Optical Coherence Tomography Angiography in Myopic Patients Quantification of retinal microvasculature and neurodegeneration changes in branch retinal vein occlusion after resolution of cystoid macular edema on optical coherence tomography angiography Machining head for a laser machining device Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease Detection of and validation of shadows in intravascular images Automated intravascular plaque classification Detection of stent struts relative to side branches Role of optical coherence tomography for distal left main stem angioplasty